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    Mpp3 MAGUK p55 scaffold protein 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 114202, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Mpp3provided by RGD
    Official Full Name
    MAGUK p55 scaffold protein 3provided by RGD
    Primary source
    RGD:620015
    See related
    EnsemblRapid:ENSRNOG00000033653 AllianceGenome:RGD:620015
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Dlg3; CSG18; Dusp3
    Summary
    Enables PDZ domain binding activity. Predicted to be located in adherens junction and apical plasma membrane. Predicted to be active in cell-cell junction and plasma membrane. Orthologous to human MPP3 (MAGUK p55 scaffold protein 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 52.7), Muscle (RPKM 13.8) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mpp3 in Genome Data Viewer
    Location:
    10q32.1
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (87445905..87475461, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (86945705..86975261, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (89930270..89959462, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene sclerostin Neighboring gene dual specificity phosphatase 3 Neighboring gene CFAP97 domain containing 1 Neighboring gene uncharacterized LOC134480879 Neighboring gene Cd300 molecule-like family member G

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A tripartite protein complex with the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Butz S, et al. Cell, 1998 Sep 18. PMID 9753324
    2. Identification of multiple binding partners for the amino-terminal domain of synapse-associated protein 97. Karnak D, et al. J Biol Chem, 2002 Nov 29. PMID 12351654
    3. Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins. Leonoudakis D, et al. J Biol Chem, 2004 May 21. PMID 15024025
    4. Sequential Elution Interactome Analysis of the Mind Bomb 1 Ubiquitin Ligase Reveals a Novel Role in Dendritic Spine Outgrowth. Mertz J, et al. Mol Cell Proteomics, 2015 Jul. PMID 25931508, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables PDZ domain binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in adherens junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in adherens junction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in apical plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cell-cell junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    MAGUK p55 subfamily member 3
    Names
    discs large homolog 3
    membrane palmitoylated protein 3
    membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
    protein Dlgh3
    protein MPP3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053668.1 → NP_446120.1  MAGUK p55 subfamily member 3

      See identical proteins and their annotated locations for NP_446120.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      A6HJG0, O88954
      UniProtKB/TrEMBL
      A0A8L2R3Z4
      Related
      ENSRNOP00000028264.5, ENSRNOT00000028264.9
      Conserved Domains (4) summary
      smart00569
      Location:71 → 121
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12039
      Location:230 → 291
      SH3_MPP3; Src Homology 3 domain of Membrane Protein, Palmitoylated 3 (or MAGUK p55 subfamily member 3)
      smart00072
      Location:395 → 571
      GuKc; Guanylate kinase homologues
      cd00992
      Location:135 → 215
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      87445905..87475461 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008767931.3 → XP_008766153.1  MAGUK p55 subfamily member 3 isoform X1

      See identical proteins and their annotated locations for XP_008766153.1

      UniProtKB/Swiss-Prot
      A6HJG0, O88954
      UniProtKB/TrEMBL
      A0A8L2R3Z4
      Conserved Domains (4) summary
      smart00569
      Location:71 → 121
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12039
      Location:230 → 291
      SH3_MPP3; Src Homology 3 domain of Membrane Protein, Palmitoylated 3 (or MAGUK p55 subfamily member 3)
      smart00072
      Location:395 → 571
      GuKc; Guanylate kinase homologues
      cd00992
      Location:135 → 215
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    2. XM_063268273.1 → XP_063124343.1  MAGUK p55 subfamily member 3 isoform X2

    3. XM_039085030.2 → XP_038940958.1  MAGUK p55 subfamily member 3 isoform X3

      Conserved Domains (3) summary
      smart00569
      Location:71 → 121
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12039
      Location:230 → 291
      SH3_MPP3; Src Homology 3 domain of Membrane Protein, Palmitoylated 3 (or MAGUK p55 subfamily member 3)
      cd00992
      Location:135 → 215
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O88954.3 GenPept UniProtKB/Swiss-Prot:O88954

    Gene LinkOut

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