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    Slc25a42 solute carrier family 25, member 42 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 689414, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Slc25a42provided by RGD
    Official Full Name
    solute carrier family 25, member 42provided by RGD
    Primary source
    RGD:1592346
    See related
    EnsemblRapid:ENSRNOG00000020345 AllianceGenome:RGD:1592346
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ADP phosphatase activity and nucleobase-containing compound transmembrane transporter activity. Predicted to be involved in nucleobase-containing compound transport. Predicted to be located in mitochondrion. Orthologous to human SLC25A42 (solute carrier family 25 member 42). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 119.2), Muscle (RPKM 88.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Slc25a42 in Genome Data Viewer
    Location:
    16p14
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (19247874..19286598)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (19213914..19251990)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (20962144..21000191)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene SURP and G patch domain containing 2 Neighboring gene U6 spliceosomal RNA Neighboring gene armadillo repeat containing 6 Neighboring gene transmembrane protein 161A Neighboring gene myocyte enhancer factor 2B Neighboring gene BLOC-1 related complex subunit 8 Neighboring gene regulatory factor X-associated ankyrin-containing protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A novel member of solute carrier family 25 (SLC25A42) is a transporter of coenzyme A and adenosine 3',5'-diphosphate in human mitochondria. Fiermonte G, et al. J Biol Chem, 2009 Jul 3. PMID 19429682, Free PMC Article
    2. Fourteen novel human members of mitochondrial solute carrier family 25 (SLC25) widely expressed in the central nervous system. Haitina T, et al. Genomics, 2006 Dec. PMID 16949250
    3. Proteomic analysis of the mouse liver mitochondrial inner membrane. Da Cruz S, et al. J Biol Chem, 2003 Oct 17. PMID 12865426
    4. Proteomic characterization of the human sperm nucleus. de Mateo S, et al. Proteomics, 2011 Jul. PMID 21630459
    5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC188302

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ADP phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ADP phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ADP phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ADP transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ADP transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ADP transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables AMP transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AMP transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables AMP transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ATP transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ATP transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables coenzyme A transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables coenzyme A transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables coenzyme A transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in ADP transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ADP transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ADP transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in AMP transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in AMP transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in AMP transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in ATP transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ATP transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ATP transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in coenzyme A transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in coenzyme A transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in coenzyme A transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    mitochondrial coenzyme A transporter SLC25A42

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001127590.1 → NP_001121062.1  mitochondrial coenzyme A transporter SLC25A42

      See identical proteins and their annotated locations for NP_001121062.1

      Status: PROVISIONAL

      Source sequence(s)
      BC160887
      UniProtKB/Swiss-Prot
      P0C546
      UniProtKB/TrEMBL
      B1H271
      Related
      ENSRNOP00000106072.1, ENSRNOT00000171044.1
      Conserved Domains (2) summary
      PTZ00169
      Location:34 → 295
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
      pfam00153
      Location:29 → 122
      Mito_carr; Mitochondrial carrier protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      19247874..19286598
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063275745.1 → XP_063131815.1  mitochondrial coenzyme A transporter SLC25A42 isoform X2

    2. XM_063275744.1 → XP_063131814.1  mitochondrial coenzyme A transporter SLC25A42 isoform X1

      UniProtKB/TrEMBL
      A6KA79

    3. XM_063275746.1 → XP_063131816.1  mitochondrial coenzyme A transporter SLC25A42 isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0C546.1 GenPept UniProtKB/Swiss-Prot:P0C546

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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