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    Ctnnd1 catenin delta 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311163, updated on 27-Nov-2024

    Summary

    Official Symbol
    Ctnnd1provided by RGD
    Official Full Name
    catenin delta 1provided by RGD
    Primary source
    RGD:1305643
    See related
    EnsemblRapid:ENSRNOG00000030790 AllianceGenome:RGD:1305643
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    P120; Catns
    Summary
    Enables beta-catenin binding activity; cell adhesion molecule binding activity; and protein tyrosine kinase binding activity. Predicted to be involved in several processes, including cell-cell adhesion mediated by cadherin; negative regulation of canonical Wnt signaling pathway; and protein stabilization. Predicted to act upstream of or within several processes, including glomerulus morphogenesis; positive regulation of protein metabolic process; and salivary gland development. Located in several cellular components, including dendritic spine; lamellipodium; and zonula adherens. Is active in several cellular components, including Schaffer collateral - CA1 synapse; hippocampal mossy fiber to CA3 synapse; and postsynaptic density, intracellular component. Biomarker of pulmonary hypertension. Human ortholog(s) of this gene implicated in blepharocheilodontic syndrome 2. Orthologous to human CTNND1 (catenin delta 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Lung (RPKM 503.6), Adrenal (RPKM 458.1) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Ctnnd1 in Genome Data Viewer
    Location:
    3q24
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (90090025..90141247, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (69683328..69734550, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (72001904..72053047, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486404 Neighboring gene uncharacterized LOC108350412 Neighboring gene BTB domain containing 18 Neighboring gene selenoprotein H

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables beta-catenin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables cadherin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cadherin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables cell adhesion molecule binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein sequestering activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein tyrosine kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell-cell adhesion mediated by cadherin ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within epithelial cell differentiation involved in salivary gland development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within glomerulus morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within kidney development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within morphogenesis of a polarized epithelium ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of peptidyl-tyrosine autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein localization to cell-cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of protein localization to cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of protein processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein stabilization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of postsynaptic membrane neurotransmitter receptor levels ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within salivary gland morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in Schaffer collateral - CA1 synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in adherens junction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in adherens junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in apicolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in bicellular tight junction ISO
    Inferred from Sequence Orthology
    more info
     
    part_of catenin complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendritic spine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of flotillin complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in growth cone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in hippocampal mossy fiber to CA3 synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lamellipodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lamellipodium ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynaptic density, intracellular component IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in presynaptic active zone cytoplasmic component IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in zonula adherens IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    catenin delta-1
    Names
    catenin (cadherin associated protein), delta 1
    catenin src
    p120 catenin

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107740.2NP_001101210.1  catenin delta-1 isoform c

      See identical proteins and their annotated locations for NP_001101210.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I5ZVG2, A6HMQ5
      Related
      ENSRNOP00000070326.3, ENSRNOT00000081400.3
      Conserved Domains (3) summary
      smart00185
      Location:397437
      ARM; Armadillo/beta-catenin-like repeats
      sd00043
      Location:368393
      ARM; armadillo repeat [structural motif]
      pfam00514
      Location:440481
      Arm; Armadillo/beta-catenin-like repeat
    2. NM_001433369.1NP_001420298.1  catenin delta-1 isoform a

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
    3. NM_001433370.1NP_001420299.1  catenin delta-1 isoform b

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
    4. NM_001433371.1NP_001420300.1  catenin delta-1 isoform c

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6HMQ5
    5. NM_001433372.1NP_001420301.1  catenin delta-1 isoform d

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6HMQ4
    6. NM_001433373.1NP_001420302.1  catenin delta-1 isoform e

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
    7. NM_001433374.1NP_001420303.1  catenin delta-1 isoform f

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
    8. NM_001433375.1NP_001420304.1  catenin delta-1 isoform f

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      90090025..90141247 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063283650.1XP_063139720.1  catenin delta-1 isoform X13

    2. XM_039104873.2XP_038960801.1  catenin delta-1 isoform X6

      UniProtKB/TrEMBL
      D3ZZZ9
      Conserved Domains (3) summary
      smart00185
      Location:397437
      ARM; Armadillo/beta-catenin-like repeats
      sd00043
      Location:368393
      ARM; armadillo repeat [structural motif]
      pfam00514
      Location:440481
      Arm; Armadillo/beta-catenin-like repeat
    3. XM_063283649.1XP_063139719.1  catenin delta-1 isoform X10

    4. XM_063283647.1XP_063139717.1  catenin delta-1 isoform X4

    5. XM_039104871.2XP_038960799.1  catenin delta-1 isoform X3

      Conserved Domains (3) summary
      smart00185
      Location:397437
      ARM; Armadillo/beta-catenin-like repeats
      sd00043
      Location:368393
      ARM; armadillo repeat [structural motif]
      pfam00514
      Location:440481
      Arm; Armadillo/beta-catenin-like repeat
    6. XM_039104877.2XP_038960805.1  catenin delta-1 isoform X12

      UniProtKB/TrEMBL
      D3ZZZ9
      Conserved Domains (4) summary
      smart00185
      Location:397437
      ARM; Armadillo/beta-catenin-like repeats
      cd13394
      Location:632740
      Syo1_like; Fungal symportin 1 (syo1) and similar proteins
      sd00043
      Location:368393
      ARM; armadillo repeat [structural motif]
      pfam00514
      Location:440481
      Arm; Armadillo/beta-catenin-like repeat
    7. XM_039104876.2XP_038960804.1  catenin delta-1 isoform X11

      UniProtKB/TrEMBL
      D3ZZZ9
      Related
      ENSRNOP00000063519.3, ENSRNOT00000064009.3
      Conserved Domains (4) summary
      smart00185
      Location:397437
      ARM; Armadillo/beta-catenin-like repeats
      cd13394
      Location:632740
      Syo1_like; Fungal symportin 1 (syo1) and similar proteins
      sd00043
      Location:368393
      ARM; armadillo repeat [structural motif]
      pfam00514
      Location:440481
      Arm; Armadillo/beta-catenin-like repeat
    8. XM_039104872.2XP_038960800.1  catenin delta-1 isoform X5

      UniProtKB/TrEMBL
      D3ZZZ9
      Conserved Domains (4) summary
      smart00185
      Location:397437
      ARM; Armadillo/beta-catenin-like repeats
      cd13394
      Location:632740
      Syo1_like; Fungal symportin 1 (syo1) and similar proteins
      sd00043
      Location:368393
      ARM; armadillo repeat [structural motif]
      pfam00514
      Location:440481
      Arm; Armadillo/beta-catenin-like repeat
    9. XM_039104875.2XP_038960803.1  catenin delta-1 isoform X8

      UniProtKB/TrEMBL
      A0A8I5ZVG2
      Conserved Domains (4) summary
      smart00185
      Location:397437
      ARM; Armadillo/beta-catenin-like repeats
      cd13394
      Location:632740
      Syo1_like; Fungal symportin 1 (syo1) and similar proteins
      sd00043
      Location:368393
      ARM; armadillo repeat [structural motif]
      pfam00514
      Location:440481
      Arm; Armadillo/beta-catenin-like repeat
    10. XM_039104874.2XP_038960802.1  catenin delta-1 isoform X7

      Related
      ENSRNOP00000082894.2, ENSRNOT00000097596.2
      Conserved Domains (4) summary
      smart00185
      Location:397437
      ARM; Armadillo/beta-catenin-like repeats
      cd13394
      Location:632740
      Syo1_like; Fungal symportin 1 (syo1) and similar proteins
      sd00043
      Location:368393
      ARM; armadillo repeat [structural motif]
      pfam00514
      Location:440481
      Arm; Armadillo/beta-catenin-like repeat
    11. XM_039104870.2XP_038960798.1  catenin delta-1 isoform X2

      UniProtKB/TrEMBL
      D3ZZZ9
      Conserved Domains (4) summary
      smart00185
      Location:397437
      ARM; Armadillo/beta-catenin-like repeats
      cd13394
      Location:632740
      Syo1_like; Fungal symportin 1 (syo1) and similar proteins
      sd00043
      Location:368393
      ARM; armadillo repeat [structural motif]
      pfam00514
      Location:440481
      Arm; Armadillo/beta-catenin-like repeat
    12. XM_006234453.5XP_006234515.1  catenin delta-1 isoform X1

      See identical proteins and their annotated locations for XP_006234515.1

      UniProtKB/TrEMBL
      A0A0G2JXM1, D3ZZZ9
      Related
      ENSRNOP00000104464.1, ENSRNOT00000164039.1
      Conserved Domains (2) summary
      cd00020
      Location:363481
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      sd00043
      Location:368393
      ARM; armadillo repeat [structural motif]
    13. XM_039104878.2XP_038960806.1  catenin delta-1 isoform X14

      UniProtKB/TrEMBL
      D3ZZZ9
      Conserved Domains (3) summary
      smart00185
      Location:296336
      ARM; Armadillo/beta-catenin-like repeats
      cd13394
      Location:531639
      Syo1_like; Fungal symportin 1 (syo1) and similar proteins
      sd00043
      Location:267292
      ARM; armadillo repeat [structural motif]
    14. XM_008761987.4XP_008760209.1  catenin delta-1 isoform X14

      UniProtKB/TrEMBL
      D3ZZZ9
      Conserved Domains (3) summary
      smart00185
      Location:296336
      ARM; Armadillo/beta-catenin-like repeats
      cd13394
      Location:531639
      Syo1_like; Fungal symportin 1 (syo1) and similar proteins
      sd00043
      Location:267292
      ARM; armadillo repeat [structural motif]
    15. XM_006234452.5XP_006234514.1  catenin delta-1 isoform X1

      See identical proteins and their annotated locations for XP_006234514.1

      UniProtKB/TrEMBL
      A0A0G2JXM1, D3ZZZ9
      Conserved Domains (2) summary
      cd00020
      Location:363481
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      sd00043
      Location:368393
      ARM; armadillo repeat [structural motif]
    16. XM_063283648.1XP_063139718.1  catenin delta-1 isoform X9