Pmpcb peptidase, mitochondrial processing subunit beta [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pmpcbprovided by RGD
Official Full Name: peptidase, mitochondrial processing subunit betaprovided by RGD
Primary source: RGD:621297
See related: EnsemblRapid:ENSRNOG00000012693 AllianceGenome:RGD:621297
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Mppb
Summary: Enables metalloendopeptidase activity. Contributes to metallopeptidase activity. Involved in protein processing involved in protein targeting to mitochondrion. Part of mitochondrial processing peptidase complex. Human ortholog(s) of this gene implicated in multiple mitochondrial dysfunctions syndrome 6. Orthologous to human PMPCB (peptidase, mitochondrial processing subunit beta). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Heart (RPKM 633.1), Adrenal (RPKM 516.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q11

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (14189807..14202584, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (13297583..13310363, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (9908838..9921615, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metalloendopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables metalloendopeptidase activity	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase activity	ISO Inferred from Sequence Orthology more info
contributes_to metallopeptidase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in protein processing	IDA Inferred from Direct Assay more info	PubMed
involved_in protein processing involved in protein targeting to mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein processing involved in protein targeting to mitochondrion	IDA Inferred from Direct Assay more info	PubMed
involved_in protein processing involved in protein targeting to mitochondrion	IEA Inferred from Electronic Annotation more info
involved_in protein processing involved in protein targeting to mitochondrion	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
part_of mitochondrial processing peptidase complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: mitochondrial-processing peptidase subunit beta

Names: P-52; beta-MPP; mitochondrial processing peptidase beta subunit; peptidase (mitochondrial processing) beta; peptidase, mitochondrial processing beta subunit

NP_071790.1

EC 3.4.24.64

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022395.2 → NP_071790.1 mitochondrial-processing peptidase subunit beta precursor

See identical proteins and their annotated locations for NP_071790.1

Status: PROVISIONAL

Source sequence(s)

L12965

UniProtKB/Swiss-Prot

Q03346, Q68G08

UniProtKB/TrEMBL

A6K5A7

Related

ENSRNOP00000017017.5, ENSRNOT00000017018.7

Conserved Domains (3) summary

COG0612
Location:46 → 478

PqqL; Predicted Zn-dependent peptidase [General function prediction only]

pfam00675
Location:68 → 215

Peptidase_M16; Insulinase (Peptidase family M16)

pfam05193
Location:220 → 404

Peptidase_M16_C; Peptidase M16 inactive domain