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    Glg1 golgi glycoprotein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29476, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Glg1provided by RGD
    Official Full Name
    golgi glycoprotein 1provided by RGD
    Primary source
    RGD:69345
    See related
    EnsemblRapid:ENSRNOG00000018668 AllianceGenome:RGD:69345
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Selel; MG-160
    Summary
    Enables fibroblast growth factor binding activity. Predicted to act upstream of or within several processes, including negative regulation of protein processing; negative regulation of transforming growth factor beta receptor signaling pathway; and regulation of chondrocyte differentiation. Located in Golgi medial cisterna. Orthologous to human GLG1 (golgi glycoprotein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Adrenal (RPKM 355.7), Kidney (RPKM 332.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Glg1 in Genome Data Viewer
    Location:
    19q12
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (56034248..56133538, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (39124892..39224178, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (42983879..43088074)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene essential MCU regulator, mitochondrial-like Neighboring gene ribosomal protein S20 like 6 Neighboring gene pyruvate dehydrogenase phosphatase regulatory subunit Neighboring gene ring finger and WD repeat domain 3 Neighboring gene U6 spliceosomal RNA Neighboring gene mixed lineage kinase domain like pseudokinase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. MG-160. A novel sialoglycoprotein of the medial cisternae of the Golgi apparatus [published eeratum appears in J Biol Chem 1989 Mar 5;264(7):4264]. Gonatas JO, et al. J Biol Chem, 1989 Jan 5. PMID 2909545
    2. Expression of E-selectin ligand-1 (CFR/ESL-1) on hepatic stellate cells: implications for leukocyte extravasation and liver metastasis. Antoine M, et al. Oncol Rep, 2009 Feb. PMID 19148508
    3. MG-160, a membrane sialoglycoprotein of the medial cisternae of the rat Golgi apparatus, binds basic fibroblast growth factor and exhibits a high level of sequence identity to a chicken fibroblast growth factor receptor. Gonatas JO, et al. J Cell Sci, 1995 Feb. PMID 7768993
    4. Natural resistance to infection with intracellular pathogens: the Nramp1 protein is recruited to the membrane of the phagosome. Gruenheid S, et al. J Exp Med, 1997 Feb 17. PMID 9034150, Free PMC Article
    5. E-selectin ligand-1 regulates growth plate homeostasis in mice by inhibiting the intracellular processing and secretion of mature TGF-beta. Yang T, et al. J Clin Invest, 2010 Jul. PMID 20530870, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. under hypoxia, ESL-1 is shed from activated hepatic stellate cells
      Title: Expression of E-selectin ligand-1 (CFR/ESL-1) on hepatic stellate cells: implications for leukocyte extravasation and liver metastasis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables fibroblast growth factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fibroblast growth factor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in bone morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within bone morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular protein transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of protein processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of protein processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transforming growth factor beta receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of protein processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of chondrocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of chondrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transforming growth factor beta receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi medial cisterna IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule organizing center IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Golgi apparatus protein 1
    Names
    E-selectin ligand 1
    ESL-1
    golgi sialoglycoprotein MG-160
    selectin, endothelial cell, ligand

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017211.2 → NP_058907.1  Golgi apparatus protein 1 precursor

      Status: PROVISIONAL

      Source sequence(s)
      U08136
      UniProtKB/Swiss-Prot
      Q62638
      UniProtKB/TrEMBL
      A6IZ85, G3V8G5
      Related
      ENSRNOP00000102342.1, ENSRNOT00000166511.1
      Conserved Domains (1) summary
      pfam00839
      Location:792 → 848
      Cys_rich_FGFR; Cysteine rich repeat

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      56034248..56133538 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039097676.2 → XP_038953604.1  Golgi apparatus protein 1 isoform X1

      UniProtKB/TrEMBL
      A6IZ85, G3V8G5
      Related
      ENSRNOP00000025570.2, ENSRNOT00000025570.5
      Conserved Domains (1) summary
      pfam00839
      Location:792 → 848
      Cys_rich_FGFR; Cysteine rich repeat
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q62638.1 GenPept UniProtKB/Swiss-Prot:Q62638

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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