Nox1 NADPH oxidase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nox1provided by RGD
Official Full Name: NADPH oxidase 1provided by RGD
Primary source: RGD:620598
See related: EnsemblRapid:ENSRNOG00000048706 AllianceGenome:RGD:620598
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables NAD(P)H oxidase H2O2-forming activity and superoxide-generating NAD(P)H oxidase activity. Involved in several processes, including cellular response to mercury ion; cellular response to platelet-derived growth factor stimulus; and positive regulation of cellular component organization. Part of NADPH oxidase complex. Used to study Parkinson's disease; pulmonary hypertension; transient cerebral ischemia; and vascular dementia. Biomarker of middle cerebral artery infarction; pulmonary hypertension; and traumatic brain injury. Orthologous to human NOX1 (NADPH oxidase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 13.3), Thymus (RPKM 12.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq32

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (101572338..101625571, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (97279058..97332291, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (104909328..104932508, complement)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Advanced glycated end-products inhibit dilation through constitutive endothelial RAGE and Nox1/4 in rat isolated skeletal muscle arteries.
Title: Advanced glycated end-products inhibit dilation through constitutive endothelial RAGE and Nox1/4 in rat isolated skeletal muscle arteries.
NADPH Oxidase 1 Mediates Acute Blood Pressure Response to Angiotensin II by Contributing to Calcium Influx in Vascular Smooth Muscle Cells.
Title: NADPH Oxidase 1 Mediates Acute Blood Pressure Response to Angiotensin II by Contributing to Calcium Influx in Vascular Smooth Muscle Cells.
CCR5 antagonist treatment inhibits vascular injury by regulating NADPH oxidase 1.
Title: CCR5 antagonist treatment inhibits vascular injury by regulating NADPH oxidase 1.
miR-145-5p attenuates inflammatory response and apoptosis in myocardial ischemia-reperfusion injury by inhibiting (NADPH) oxidase homolog 1.
Title: miR-145-5p attenuates inflammatory response and apoptosis in myocardial ischemia-reperfusion injury by inhibiting (NADPH) oxidase homolog 1.
Haematoxylon campechianum Extract Ameliorates Neuropathic Pain via Inhibition of NF-kappaB/TNF-alpha/NOX/iNOS Signalling Pathway in a Rat Model of Chronic Constriction Injury.
Title: Haematoxylon campechianum Extract Ameliorates Neuropathic Pain via Inhibition of NF-κB/TNF-α/NOX/iNOS Signalling Pathway in a Rat Model of Chronic Constriction Injury.
Assessing the effects of Ang-(1-7) therapy following transient middle cerebral artery occlusion.
Title: Assessing the effects of Ang-(1-7) therapy following transient middle cerebral artery occlusion.
TNFalpha in the paraventricular nucleus modulates adipose afferent reflex and contributes to sympathoexcitation in obesity-related hypertension possibly through NADPH oxidase-dependent ROS generation
Title: Adipose afferent reflex is enhanced by TNFα in paraventricular nucleus through NADPH oxidase-dependent ROS generation in obesity-related hypertensive rats.
this study is the first to draw a direct link between AT1 receptors, Nox1 mediated generation of reactive oxygen species (ROS), CaV3.2 suppression and the modulation of BKCa mediated feedback.
Title: Reactive Oxygen Species Mediate the Suppression of Arterial Smooth Muscle T-type Ca(2+) Channels by Angiotensin II.
Nox1/4 dual inhibitor GKT137831 protects against hypertensive cardiac remodelling in AAC-induced hypertensive rats, and the inhibition of ADAM17-dependent proinflammatory cytokines-induced signalling pathways.
Title: Nox1/4 dual inhibitor GKT137831 attenuates hypertensive cardiac remodelling associating with the inhibition of ADAM17-dependent proinflammatory cytokines-induced signalling pathways in the rats with abdominal artery constriction.
Nox1 was able to increase SOD activity, thereby demonstrating its positive effect on the proliferation of MCTPASMCs.
Title: Mechanisms of N‑acetylcysteine in reducing monocrotaline‑induced pulmonary hypertension in rats: Inhibiting the expression of Nox1 in pulmonary vascular smooth muscle cells.

Submit: New GeneRIF Correction See all GeneRIFs (115)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables NAD(P)H oxidase H2O2-forming activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables small GTPase binding	IEA Inferred from Electronic Annotation more info
enables small GTPase binding	ISO Inferred from Sequence Orthology more info
enables superoxide-generating NAD(P)H oxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables superoxide-generating NAD(P)H oxidase activity	IDA Inferred from Direct Assay more info	PubMed
enables superoxide-generating NAD(P)H oxidase activity	IEA Inferred from Electronic Annotation more info
enables superoxide-generating NAD(P)H oxidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables superoxide-generating NAD(P)H oxidase activity	ISO Inferred from Sequence Orthology more info
enables superoxide-generating NAD(P)H oxidase activity	TAS Traceable Author Statement more info	PubMed
enables superoxide-generating NADPH oxidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in JNK cascade	IEA Inferred from Electronic Annotation more info
acts_upstream_of JNK cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in cell chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell migration	IEA Inferred from Electronic Annotation more info
involved_in cell migration	ISO Inferred from Sequence Orthology more info
involved_in cellular response to angiotensin	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to hyperoxia	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to hyperoxia	ISO Inferred from Sequence Orthology more info
involved_in cellular response to interleukin-1	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to mercury ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to platelet-derived growth factor stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in defense response	IBA Inferred from Biological aspect of Ancestor more info
involved_in extracellular matrix organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within extracellular matrix organization	ISO Inferred from Sequence Orthology more info
involved_in glutathione metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hydrogen peroxide metabolic process	IEA Inferred from Electronic Annotation more info
involved_in hydrogen peroxide metabolic process	ISO Inferred from Sequence Orthology more info
involved_in intrinsic apoptotic signaling pathway in response to oxidative stress	IEA Inferred from Electronic Annotation more info
acts_upstream_of intrinsic apoptotic signaling pathway in response to oxidative stress	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron maturation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oxygen metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within oxygen metabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of JNK cascade	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of JNK cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of inclusion body assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of integrin biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of integrin biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of reactive oxygen species metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of smooth muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of superoxide anion generation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of vascular associated smooth muscle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of vascular associated smooth muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of vascular endothelial growth factor production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of vascular endothelial growth factor production	ISO Inferred from Sequence Orthology more info
involved_in regulation of systemic arterial blood pressure by renin-angiotensin	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of systemic arterial blood pressure by renin-angiotensin	ISO Inferred from Sequence Orthology more info
involved_in response to reactive oxygen species	IDA Inferred from Direct Assay more info	PubMed
involved_in superoxide anion generation	IBA Inferred from Biological aspect of Ancestor more info
involved_in superoxide anion generation	IEA Inferred from Electronic Annotation more info
involved_in superoxide anion generation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within superoxide anion generation	ISO Inferred from Sequence Orthology more info
involved_in superoxide anion generation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of NADPH oxidase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of NADPH oxidase complex	IDA Inferred from Direct Assay more info	PubMed
part_of NADPH oxidase complex	IEA Inferred from Electronic Annotation more info
part_of NADPH oxidase complex	ISO Inferred from Sequence Orthology more info
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in early endosome	IEA Inferred from Electronic Annotation more info
located_in early endosome	ISO Inferred from Sequence Orthology more info
located_in endosome	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: NADPH oxidase 1

Names: MOX-1; MOX1; NADH/NADPH mitogenic oxidase subunit p65-mox; NOH-1; NOX-1; mitogenic oxidase 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053683.2 → NP_446135.2 NADPH oxidase 1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000021

UniProtKB/Swiss-Prot

Q9WV87

UniProtKB/TrEMBL

A6IVE4, M0R934

Related

ENSRNOP00000065995.1, ENSRNOT00000075325.3

Conserved Domains (2) summary

cd06186
Location:296 → 563

NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...

pfam01794
Location:74 → 217

Ferric_reduct; Ferric reductase like transmembrane component

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086039.1 Reference GRCr8

Range

101572338..101625571 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039099398.2 → XP_038955326.1 NADPH oxidase 1 isoform X1

UniProtKB/TrEMBL

A0A8I6AG93

Conserved Domains (2) summary

cd06186
Location:232 → 499

NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...

pfam01794
Location:10 → 153

Ferric_reduct; Ferric reductase like transmembrane component
XM_039099397.2 → XP_038955325.1 NADPH oxidase 1 isoform X1

UniProtKB/TrEMBL

A0A8I6AG93

Conserved Domains (2) summary

cd06186
Location:232 → 499

NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...

pfam01794
Location:10 → 153

Ferric_reduct; Ferric reductase like transmembrane component