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    Akap8l A-kinase anchoring protein 8 like [ Rattus norvegicus (Norway rat) ]

    Gene ID: 299569, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Akap8lprovided by RGD
    Official Full Name
    A-kinase anchoring protein 8 likeprovided by RGD
    Primary source
    RGD:1359200
    See related
    EnsemblRapid:ENSRNOG00000006355 AllianceGenome:RGD:1359200
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable histone deacetylase binding activity; lamin binding activity; and protein kinase A regulatory subunit binding activity. Predicted to be involved in several processes, including cell cycle G2/M phase transition; mitotic chromosome condensation; and regulation of mRNA export from nucleus. Predicted to be located in chromatin; cytoplasm; and nuclear speck. Predicted to be part of ribonucleoprotein complex. Predicted to be active in nuclear matrix. Orthologous to human AKAP8L (A-kinase anchoring protein 8 like). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 171.9), Lung (RPKM 156.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Akap8l in Genome Data Viewer
    Location:
    7q11
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (11983215..12012843, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (11332671..11362287, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (14340168..14369835, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene bromodomain containing 4 Neighboring gene uncharacterized LOC134479823 Neighboring gene A-kinase anchoring protein 8 Neighboring gene uncharacterized LOC134479821 Neighboring gene WIZ zinc finger

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Protein kinase A associates with HA95 and affects transcriptional coactivation by Epstein-Barr virus nuclear proteins. Han I, et al. Mol Cell Biol, 2002 Apr. PMID 11884601, Free PMC Article
    2. Mapping the functional domains of HAP95, a protein that binds RNA helicase A and activates the constitutive transport element of type D retroviruses. Yang JP, et al. J Biol Chem, 2001 Aug 17. PMID 11402034
    3. Involvement of the catalytic subunit of protein kinase A and of HA95 in pre-mRNA splicing. Kvissel AK, et al. Exp Cell Res, 2007 Aug 1. PMID 17594903
    4. HA95 is a protein of the chromatin and nuclear matrix regulating nuclear envelope dynamics. Martins SB, et al. J Cell Sci, 2000 Nov. PMID 11034899
    5. Interaction of the nuclear matrix protein NAKAP with HypA and huntingtin: implications for nuclear toxicity in Huntington's disease pathogenesis. Sayer JA, et al. Neuromolecular Med, 2005. PMID 16391387

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone deacetylase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lamin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase A regulatory subunit binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell cycle G2/M phase transition ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic chromosome condensation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nuclear membrane disassembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mRNA export from nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nuclear matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    A-kinase anchor protein 8-like
    Names
    A kinase (PRKA) anchor protein 8-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013946.1 → NP_001013968.1  A-kinase anchor protein 8-like

      See identical proteins and their annotated locations for NP_001013968.1

      Status: PROVISIONAL

      Source sequence(s)
      BC085785
      UniProtKB/TrEMBL
      A0A0G2K0P0, A0A9K3Y6N0, F1LP74, Q5U306
      Related
      ENSRNOP00000092015.1, ENSRNOT00000110147.2
      Conserved Domains (1) summary
      pfam04988
      Location:390 → 554
      AKAP95; A-kinase anchoring protein 95 (AKAP95)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      11983215..12012843 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006241054.3 → XP_006241116.1  A-kinase anchor protein 8-like isoform X1

      UniProtKB/TrEMBL
      A0A0G2K0P0
      Related
      ENSRNOP00000008560.7, ENSRNOT00000008560.9
      Conserved Domains (1) summary
      pfam04988
      Location:356 → 520
      AKAP95; A-kinase anchoring protein 95 (AKAP95)

    2. XM_063263156.1 → XP_063119226.1  A-kinase anchor protein 8-like isoform X3

    3. XM_006241055.4 → XP_006241117.1  A-kinase anchor protein 8-like isoform X2

      Conserved Domains (1) summary
      pfam04988
      Location:390 → 513
      AKAP95; A-kinase anchoring protein 95 (AKAP95)

    4. XM_039078627.2 → XP_038934555.1  A-kinase anchor protein 8-like isoform X5

    5. XM_063263158.1 → XP_063119228.1  A-kinase anchor protein 8-like isoform X5

    6. XM_063263159.1 → XP_063119229.1  A-kinase anchor protein 8-like isoform X7

    7. XM_039078629.2 → XP_038934557.1  A-kinase anchor protein 8-like isoform X6

    8. XM_063263157.1 → XP_063119227.1  A-kinase anchor protein 8-like isoform X4

    RNA

    1. XR_001838673.2 RNA Sequence

    2. XR_005486554.2 RNA Sequence

    3. XR_010052950.1 RNA Sequence

    4. XR_010052949.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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