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    Cep295 centrosomal protein 295 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363018, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cep295provided by RGD
    Official Full Name
    centrosomal protein 295provided by RGD
    Primary source
    RGD:1311723
    See related
    EnsemblRapid:ENSRNOG00000010999 AllianceGenome:RGD:1311723
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1311723
    Summary
    Predicted to enable microtubule binding activity. Predicted to be involved in several processes, including centriole replication; positive regulation of protein acetylation; and regulation of centrosome duplication. Predicted to be located in cytoplasm; mitotic spindle microtubule; and plasma membrane. Predicted to be active in centriole; centrosome; and cytosol. Orthologous to human CEP295 (centrosomal protein 295). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 147.2), Spleen (RPKM 90.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cep295 in Genome Data Viewer
    Location:
    8q12
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (20437967..20475968, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (12156568..12194542, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (13871065..13909249, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA32 Neighboring gene small nucleolar RNA U2-30 Neighboring gene small nucleolar RNA U2-19 Neighboring gene TATA-box binding protein associated factor, RNA polymerase I subunit D Neighboring gene small nucleolar RNA, H/ACA box 25B Neighboring gene V-type proton ATPase subunit G 1 pseudogene Neighboring gene single-pass membrane protein with coiled-coil domains 4 Neighboring gene uncharacterized LOC134479995

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Stabilization of cartwheel-less centrioles for duplication requires CEP295-mediated centriole-to-centrosome conversion. Izquierdo D, et al. Cell Rep, 2014 Aug 21. PMID 25131205, Free PMC Article
    2. Centriolar association of ALMS1 and likely centrosomal functions of the ALMS motif-containing proteins C10orf90 and KIAA1731. Knorz VJ, et al. Mol Biol Cell, 2010 Nov 1. PMID 20844083, Free PMC Article
    3. CEP295 interacts with microtubules and is required for centriole elongation. Chang CW, et al. J Cell Sci, 2016 Jul 1. PMID 27185865, Free PMC Article
    4. Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. Jakobsen L, et al. EMBO J, 2011 Apr 20. PMID 21399614, Free PMC Article
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA1731

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables microtubule binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell projection organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in centriole replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in centriole replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in centriole replication ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of centriole elongation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of centriole elongation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of centriole elongation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of centrosome duplication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of centrosome duplication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of centrosome duplication ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of establishment of protein localization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of establishment of protein localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of establishment of protein localization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of protein acetylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of protein acetylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein acetylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of centriole replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in centriole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centriole IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centriole ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centriole ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitotic spindle microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitotic spindle microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitotic spindle microtubule ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    centrosomal protein of 295 kDa
    Names
    KIAA1731-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271048.3 → NP_001257977.3  centrosomal protein of 295 kDa isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A0G2K417
      Related
      ENSRNOP00000072866.2, ENSRNOT00000078372.3

    2. NM_001433863.1 → NP_001420792.1  centrosomal protein of 295 kDa isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      A4L9P8

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      20437967..20475968 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063265721.1 → XP_063121791.1  centrosomal protein of 295 kDa isoform X16

      UniProtKB/Swiss-Prot
      A4L9P8

    2. XM_063265710.1 → XP_063121780.1  centrosomal protein of 295 kDa isoform X6

      UniProtKB/TrEMBL
      A0A8I5Y8G6

    3. XM_063265722.1 → XP_063121792.1  centrosomal protein of 295 kDa isoform X17

      UniProtKB/Swiss-Prot
      A4L9P8

    4. XM_039081702.2 → XP_038937630.1  centrosomal protein of 295 kDa isoform X15

      UniProtKB/Swiss-Prot
      A4L9P8
      Conserved Domains (1) summary
      PTZ00121
      Location:74 → 586
      PTZ00121; MAEBL; Provisional

    5. XM_063265720.1 → XP_063121790.1  centrosomal protein of 295 kDa isoform X14

      UniProtKB/Swiss-Prot
      A4L9P8

    6. XM_063265714.1 → XP_063121784.1  centrosomal protein of 295 kDa isoform X11

      UniProtKB/TrEMBL
      A0A8I5Y8G6

    7. XM_063265712.1 → XP_063121782.1  centrosomal protein of 295 kDa isoform X9

      UniProtKB/TrEMBL
      A0A8I5Y8G6

    8. XM_039081696.2 → XP_038937624.1  centrosomal protein of 295 kDa isoform X4

      UniProtKB/TrEMBL
      A0A8I5Y8G6
      Conserved Domains (1) summary
      PTZ00121
      Location:74 → 586
      PTZ00121; MAEBL; Provisional

    9. XM_039081697.2 → XP_038937625.1  centrosomal protein of 295 kDa isoform X8

      UniProtKB/TrEMBL
      A0A0G2K773, A0A8I5Y8G6
      Related
      ENSRNOP00000074090.1, ENSRNOT00000083011.3
      Conserved Domains (1) summary
      PTZ00121
      Location:74 → 586
      PTZ00121; MAEBL; Provisional

    10. XM_006242549.5 → XP_006242611.2  centrosomal protein of 295 kDa isoform X3

      UniProtKB/TrEMBL
      A0A8I5Y8G6, A0A8L2QGZ6
      Related
      ENSRNOP00000029431.5, ENSRNOT00000029634.7
      Conserved Domains (2) summary
      PTZ00121
      Location:74 → 586
      PTZ00121; MAEBL; Provisional
      PRK10263
      Location:658 → 810
      PRK10263; DNA translocase FtsK; Provisional

    11. XM_063265711.1 → XP_063121781.1  centrosomal protein of 295 kDa isoform X7

      UniProtKB/TrEMBL
      A0A8I5Y8G6

    12. XM_063265708.1 → XP_063121778.1  centrosomal protein of 295 kDa isoform X2

      UniProtKB/TrEMBL
      A0A8I5Y8G6

    13. XM_063265713.1 → XP_063121783.1  centrosomal protein of 295 kDa isoform X10

      UniProtKB/TrEMBL
      A0A8I5Y8G6

    14. XM_063265709.1 → XP_063121779.1  centrosomal protein of 295 kDa isoform X5

      UniProtKB/TrEMBL
      A0A8I5Y8G6

    15. XM_063265707.1 → XP_063121777.1  centrosomal protein of 295 kDa isoform X1

      UniProtKB/TrEMBL
      A0A8I5Y8G6

    16. XM_063265715.1 → XP_063121785.1  centrosomal protein of 295 kDa isoform X12

      UniProtKB/TrEMBL
      A6JNC9

    17. XM_063265719.1 → XP_063121789.1  centrosomal protein of 295 kDa isoform X13

      UniProtKB/TrEMBL
      A6JNC9

    18. XM_063265717.1 → XP_063121787.1  centrosomal protein of 295 kDa isoform X13

      UniProtKB/TrEMBL
      A6JNC9

    19. XM_063265716.1 → XP_063121786.1  centrosomal protein of 295 kDa isoform X13

      UniProtKB/TrEMBL
      A6JNC9

    20. XM_063265718.1 → XP_063121788.1  centrosomal protein of 295 kDa isoform X13

      UniProtKB/TrEMBL
      A6JNC9

    21. XM_063265723.1 → XP_063121793.1  centrosomal protein of 295 kDa isoform X18

    RNA

    1. XR_010053990.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A4L9P8.2 GenPept UniProtKB/Swiss-Prot:A4L9P8

    Gene LinkOut

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