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    Rad51ap1 RAD51 associated protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 689055, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Rad51ap1provided by RGD
    Official Full Name
    RAD51 associated protein 1provided by RGD
    Primary source
    RGD:1597431
    See related
    EnsemblRapid:ENSRNOG00000059878 AllianceGenome:RGD:1597431
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable nucleic acid binding activity. Predicted to be involved in DNA repair; cellular response to ionizing radiation; and positive regulation of DNA recombination. Predicted to act upstream of or within DNA recombination. Predicted to be located in chromatin and nucleus. Predicted to be part of protein-containing complex. Orthologous to human RAD51AP1 (RAD51 associated protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 46.9), Testes (RPKM 32.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rad51ap1 in Genome Data Viewer
    Location:
    4q42
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (161445610..161458661, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (159759454..159772473, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (159469803..159482869, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486843 Neighboring gene A-kinase anchoring protein 3 Neighboring gene dual specificity tyrosine phosphorylation regulated kinase 4 Neighboring gene FERRY endosomal RAB5 effector complex subunit 3 Neighboring gene ribosomal protein S2, pseudogene 33

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A novel nucleic acid-binding protein that interacts with human rad51 recombinase. Kovalenko OV, et al. Nucleic Acids Res, 1997 Dec 15. PMID 9396801, Free PMC Article
    2. RAD51AP2, a novel vertebrate- and meiotic-specific protein, shares a conserved RAD51-interacting C-terminal domain with RAD51AP1/PIR51. Kovalenko OV, et al. Nucleic Acids Res, 2006. PMID 16990250, Free PMC Article
    3. RAB22 and RAB163/mouse BRCA2: proteins that specifically interact with the RAD51 protein. Mizuta R, et al. Proc Natl Acad Sci U S A, 1997 Jun 24. PMID 9192668, Free PMC Article
    4. NUCKS1 is a novel RAD51AP1 paralog important for homologous recombination and genome stability. Parplys AC, et al. Nucleic Acids Res, 2015 Nov 16. PMID 26323318, Free PMC Article
    5. FIGNL1-containing protein complex is required for efficient homologous recombination repair. Yuan J, et al. Proc Natl Acad Sci U S A, 2013 Jun 25. PMID 23754376, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC156698

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables D-loop DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA secondary structure binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables double-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables single-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables single-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within DNA recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to ionizing radiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in interstrand cross-link repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in interstrand cross-link repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of reciprocal meiotic recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    RAD51-associated protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001079711.2 → NP_001073179.1  RAD51-associated protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001073179.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A0A8I6GE54, A1A5P3
      Related
      ENSRNOP00000073657.2, ENSRNOT00000088333.3
      Conserved Domains (1) summary
      pfam15696
      Location:303 → 330
      RAD51_interact; RAD51 interacting motif

    2. NM_001398921.1 → NP_001385850.1  RAD51-associated protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A6ILW7
      Conserved Domains (2) summary
      PTZ00459
      Location:94 → 261
      PTZ00459; mucin-associated surface protein (MASP); Provisional
      pfam15696
      Location:304 → 331
      RAD51_interact; RAD51 interacting motif

    3. NM_001398922.1 → NP_001385851.1  RAD51-associated protein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      161445610..161458661 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063286719.1 → XP_063142789.1  RAD51-associated protein 1 isoform X4

      Related
      ENSRNOP00000085679.2, ENSRNOT00000119755.2

    2. XM_063286717.1 → XP_063142787.1  RAD51-associated protein 1 isoform X1

    3. XM_063286718.1 → XP_063142788.1  RAD51-associated protein 1 isoform X2

    4. XM_006237504.5 → XP_006237566.1  RAD51-associated protein 1 isoform X3

      Conserved Domains (1) summary
      PTZ00459
      Location:94 → 301
      PTZ00459; mucin-associated surface protein (MASP); Provisional

    5. XM_039108380.2 → XP_038964308.1  RAD51-associated protein 1 isoform X5

      Conserved Domains (2) summary
      PTZ00459
      Location:24 → 191
      PTZ00459; mucin-associated surface protein (MASP); Provisional
      pfam15696
      Location:234 → 261
      RAD51_interact; RAD51 interacting motif
    Nucleotide Protein Strain
    Heading Accession and Version

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