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    Ccsap centriole, cilia and spindle-associated protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 307926, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ccsapprovided by RGD
    Official Full Name
    centriole, cilia and spindle-associated proteinprovided by RGD
    Primary source
    RGD:1563235
    See related
    AllianceGenome:RGD:1563235
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1563235
    Summary
    Predicted to enable microtubule binding activity. Predicted to be involved in mitotic spindle microtubule depolymerization and regulation of mitotic spindle assembly. Predicted to be located in centrosome; cilium; and mitotic spindle astral microtubule. Predicted to be active in axon; ciliary transition zone; and cytoskeleton. Orthologous to human CCSAP (centriole, cilia and spindle associated protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 88.5), Thymus (RPKM 39.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ccsap in Genome Data Viewer
    Location:
    19q12
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (68722417..68740908, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (51824954..51843469, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (56615326..56634031, complement)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108348963 Neighboring gene uncharacterized LOC134483403 Neighboring gene RAB4A, member RAS oncogene family Neighboring gene uncharacterized LOC108348965 Neighboring gene actin, alpha 1, skeletal muscle

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. CSAP localizes to polyglutamylated microtubules and promotes proper cilia function and zebrafish development. Backer CB, et al. Mol Biol Cell, 2012 Jun. PMID 22493317, Free PMC Article
    2. Polyglutamylated Tubulin Binding Protein C1orf96/CSAP Is Involved in Microtubule Stabilization in Mitotic Spindles. Ohta S, et al. PLoS One, 2015. PMID 26562023, Free PMC Article
    3. Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. Jakobsen L, et al. EMBO J, 2011 Apr 20. PMID 21399614, Free PMC Article
    4. Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, et al. J Proteome Res, 2012 Sep 7. PMID 22871113, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitotic spindle microtubule depolymerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mitotic spindle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of mitotic spindle assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in axoneme IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in axoneme ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in centriole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centriole ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in ciliary basal body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in ciliary basal body ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in ciliary transition zone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in ciliary transition zone ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitotic spindle astral microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in spindle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in spindle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    centriole, cilia and spindle-associated protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107441.1 → NP_001100911.1  centriole, cilia and spindle-associated protein

      See identical proteins and their annotated locations for NP_001100911.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474054
      UniProtKB/TrEMBL
      A6KIZ1, D3ZZM9
      Conserved Domains (1) summary
      pfam15748
      Location:7 → 251
      CCSAP; Centriole, cilia and spindle-associated

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      68722417..68740908 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006255811.5 → XP_006255873.1  centriole, cilia and spindle-associated protein isoform X1

      See identical proteins and their annotated locations for XP_006255873.1

      UniProtKB/TrEMBL
      A6KIZ1, D3ZZM9
      Conserved Domains (1) summary
      pfam15748
      Location:7 → 251
      CCSAP; Centriole, cilia and spindle-associated

    2. XM_063278071.1 → XP_063134141.1  centriole, cilia and spindle-associated protein isoform X1

      UniProtKB/TrEMBL
      A6KIZ1, D3ZZM9
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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