Engase endo-beta-N-acetylglucosaminidase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Engaseprovided by RGD
Official Full Name: endo-beta-N-acetylglucosaminidaseprovided by RGD
Primary source: RGD:1310868
See related: EnsemblRapid:ENSRNOG00000027498 AllianceGenome:RGD:1310868
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1310868
Summary: Predicted to enable mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity. Predicted to be involved in N-glycan processing. Predicted to act upstream of or within protein deglycosylation. Predicted to be located in cytosol. Orthologous to human ENGASE (endo-beta-N-acetylglucosaminidase). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Spleen (RPKM 75.1), Thymus (RPKM 58.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q32.3

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (104205753..104218416)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (103707169..103719833)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (107502636..107515300)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in N-glycan processing	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein deglycosylation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cytosolic endo-beta-N-acetylglucosaminidase

NP_001100540.1

EC 3.2.1.96

XP_006247865.1

EC 3.2.1.96

XP_006247866.1

EC 3.2.1.96

XP_038942141.1

EC 3.2.1.96

XP_063125315.1

EC 3.2.1.96

XP_063125316.1

EC 3.2.1.96

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107070.1 → NP_001100540.1 cytosolic endo-beta-N-acetylglucosaminidase

See identical proteins and their annotated locations for NP_001100540.1

Status: PROVISIONAL

Source sequence(s)

CH473948

UniProtKB/TrEMBL

A0A8I6GLC2, A6HL61

Conserved Domains (1) summary

cd06547
Location:116 → 426

GH85_ENGase; Endo-beta-N-acetylglucosaminidase (ENGase) hydrolyzes the N-N'-diacetylchitobiosyl core of N-glycosylproteins. The beta-1,4-glycosyl bond located between two N-acetylglucosamine residues is hydrolyzed such that N-acetylglucosamine 1 remains with the ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

104205753..104218416

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006247803.3 → XP_006247865.1 cytosolic endo-beta-N-acetylglucosaminidase isoform X1

UniProtKB/TrEMBL

A0A8I6GLC2, D4AE03

Conserved Domains (1) summary

cd06547
Location:116 → 426

GH85_ENGase; Endo-beta-N-acetylglucosaminidase (ENGase) hydrolyzes the N-N'-diacetylchitobiosyl core of N-glycosylproteins. The beta-1,4-glycosyl bond located between two N-acetylglucosamine residues is hydrolyzed such that N-acetylglucosamine 1 remains with the ...
XM_063269246.1 → XP_063125316.1 cytosolic endo-beta-N-acetylglucosaminidase isoform X5
XM_039086213.2 → XP_038942141.1 cytosolic endo-beta-N-acetylglucosaminidase isoform X3

UniProtKB/TrEMBL

A0A8I6GLC2

Conserved Domains (1) summary

cd06547
Location:27 → 337

GH85_ENGase; Endo-beta-N-acetylglucosaminidase (ENGase) hydrolyzes the N-N'-diacetylchitobiosyl core of N-glycosylproteins. The beta-1,4-glycosyl bond located between two N-acetylglucosamine residues is hydrolyzed such that N-acetylglucosamine 1 remains with the ...
XM_063269245.1 → XP_063125315.1 cytosolic endo-beta-N-acetylglucosaminidase isoform X4
XM_006247804.5 → XP_006247866.1 cytosolic endo-beta-N-acetylglucosaminidase isoform X2

UniProtKB/TrEMBL

A0A8I6GLC2

Related

ENSRNOP00000038006.6, ENSRNOT00000038088.7

Conserved Domains (1) summary

cd06547
Location:93 → 403

GH85_ENGase; Endo-beta-N-acetylglucosaminidase (ENGase) hydrolyzes the N-N'-diacetylchitobiosyl core of N-glycosylproteins. The beta-1,4-glycosyl bond located between two N-acetylglucosamine residues is hydrolyzed such that N-acetylglucosamine 1 remains with the ...