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    Plekho1 pleckstrin homology domain containing O1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 310674, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Plekho1provided by RGD
    Official Full Name
    pleckstrin homology domain containing O1provided by RGD
    Primary source
    RGD:1311487
    See related
    EnsemblRapid:ENSRNOG00000021170 AllianceGenome:RGD:1311487
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ckip1; RGD1311487
    Summary
    Predicted to be involved in regulation of myoblast fusion. Predicted to act upstream of or within several processes, including lamellipodium morphogenesis; myoblast fusion; and myoblast migration. Predicted to be located in cytoplasm and nucleus. Predicted to be active in muscle cell projection membrane and ruffle membrane. Orthologous to human PLEKHO1 (pleckstrin homology domain containing O1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 253.5), Spleen (RPKM 168.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Plekho1 in Genome Data Viewer
    Location:
    2q34
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (186233435..186242114, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (183544487..183552928, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (198112104..198120202, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene acidic nuclear phosphoprotein 32 family member E Neighboring gene ubiquitin A-52 residue ribosomal protein fusion product 1 like 1 Neighboring gene vacuolar protein sorting 45 homolog Neighboring gene 60S ribosomal protein L15 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Overexpression of CKIP-1 alleviates hypoxia-induced cardiomyocyte injury by up-regulating Nrf2 antioxidant signaling via Keap1 inhibition. Ren J, et al. Biochimie, 2019 Aug. PMID 31201843
    2. Increased PLEKHO1 within osteoblasts suppresses Smad-dependent BMP signaling to inhibit bone formation during aging. Liu J, et al. Aging Cell, 2017 Apr. PMID 28083909, Free PMC Article
    3. CKIP-1 regulates mammalian and zebrafish myoblast fusion. Baas D, et al. J Cell Sci, 2012 Aug 15. PMID 22553210
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CKIP-1 alleviates hypoxia-induced cardiomyocyte injury through the up-regulation of Nrf2 antioxidant signaling via the down-regulation of Keap1, suggesting a potential role for CKIP-1 in myocardial infarction.
      Title: Overexpression of CKIP-1 alleviates hypoxia-induced cardiomyocyte injury by up-regulating Nrf2 antioxidant signaling via Keap1 inhibition.
    2. the increased PLEKHO1 could suppress Smad-dependent BMP signaling to inhibit bone formation during aging.
      Title: Increased PLEKHO1 within osteoblasts suppresses Smad-dependent BMP signaling to inhibit bone formation during aging.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC109581

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in lamellipodium morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lamellipodium morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in myoblast fusion IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within myoblast fusion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in myoblast migration IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within myoblast migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell shape IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of cell shape ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of myoblast fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in muscle cell projection membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in muscle cell projection membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in muscle cell projection membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in ruffle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in ruffle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ruffle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    pleckstrin homology domain-containing family O member 1
    Names
    CK2 interacting protein 1
    PH domain-containing family O member 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025119.1 → NP_001020290.1  pleckstrin homology domain-containing family O member 1

      See identical proteins and their annotated locations for NP_001020290.1

      Status: PROVISIONAL

      Source sequence(s)
      BC091420
      UniProtKB/Swiss-Prot
      Q5BJM5
      UniProtKB/TrEMBL
      A6K347
      Related
      ENSRNOP00000108174.1, ENSRNOT00000122271.1
      Conserved Domains (3) summary
      cd13317
      Location:21 → 126
      PH_PLEKHO1_PLEKHO2; Pleckstrin homology domain-containing family O Pleckstrin homology domain
      pfam00169
      Location:25 → 130
      PH; PH domain
      pfam15764
      Location:236 → 381
      DUF4693; Domain of unknown function (DUF4693)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      186233435..186242114 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039102374.2 → XP_038958302.1  pleckstrin homology domain-containing family O member 1 isoform X3

      Conserved Domains (1) summary
      cl17171
      Location:15 → 77
      PH-like; Pleckstrin homology-like domain

    2. XM_039102375.2 → XP_038958303.1  pleckstrin homology domain-containing family O member 1 isoform X4

      Conserved Domains (1) summary
      cl17171
      Location:13 → 71
      PH-like; Pleckstrin homology-like domain

    3. XM_039102373.2 → XP_038958301.1  pleckstrin homology domain-containing family O member 1 isoform X2

      UniProtKB/TrEMBL
      A6K346
      Conserved Domains (1) summary
      cl17171
      Location:21 → 79
      PH-like; Pleckstrin homology-like domain

    4. XM_063281879.1 → XP_063137949.1  pleckstrin homology domain-containing family O member 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2KBB3
      Related
      ENSRNOP00000075725.2, ENSRNOT00000079621.3
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5BJM5.1 GenPept UniProtKB/Swiss-Prot:Q5BJM5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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