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    Thoc7 THO complex subunit 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305714, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Thoc7provided by RGD
    Official Full Name
    THO complex subunit 7provided by RGD
    Primary source
    RGD:1305475
    See related
    EnsemblRapid:ENSRNOG00000007701 AllianceGenome:RGD:1305475
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1305475
    Summary
    Predicted to be involved in mRNA export from nucleus. Predicted to be located in chromosome, telomeric region; cytosol; and nuclear speck. Predicted to be part of THO complex part of transcription export complex. Orthologous to human THOC7 (THO complex subunit 7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 216.3), Kidney (RPKM 180.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Thoc7 in Genome Data Viewer
    Location:
    15p16
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (13692855..13707692)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (11262362..11277200)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (12569235..12584101)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene ataxin 7 Neighboring gene uncharacterized LOC134481947 Neighboring gene U6 spliceosomal RNA Neighboring gene similar to human chromosome 3 open reading frame 49 Neighboring gene cadherin related family member 18 Neighboring gene U6 spliceosomal RNA Neighboring gene U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Nuclear localization of the pre-mRNA associating protein THOC7 depends upon its direct interaction with Fms tyrosine kinase interacting protein (FMIP). El Bounkari O, et al. FEBS Lett, 2009 Jan 5. PMID 19059247
    2. Identification and characterization of NIF3L1 BP1, a novel cytoplasmic interaction partner of the NIF3L1 protein. Tascou S, et al. Biochem Biophys Res Commun, 2003 Sep 19. PMID 12951069
    3. Linking transcriptional elongation and messenger RNA export to metastatic breast cancers. Guo S, et al. Cancer Res, 2005 Apr 15. PMID 15833825
    4. mRNA export and the TREX complex. Katahira J. Biochim Biophys Acta, 2012 Jun. PMID 22178508
    5. Recruitment of the complete hTREX complex is required for Kaposi's sarcoma-associated herpesvirus intronless mRNA nuclear export and virus replication. Boyne JR, et al. PLoS Pathog, 2008 Oct. PMID 18974867, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in mRNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA export from nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of THO complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of THO complex part of transcription export complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of THO complex part of transcription export complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription export complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    THO complex subunit 7 homolog
    Names
    THO complex 7 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271293.1 → NP_001258222.1  THO complex subunit 7 homolog isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      FM110383, JAXUCZ010000015
      UniProtKB/TrEMBL
      F1LXS6
      Related
      ENSRNOP00000010675.7, ENSRNOT00000010675.9
      Conserved Domains (1) summary
      pfam05615
      Location:7 → 136
      THOC7; Tho complex subunit 7

    2. NM_001271294.1 → NP_001258223.1  THO complex subunit 7 homolog isoform 2

      See identical proteins and their annotated locations for NP_001258223.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate first exon compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      EV771598, FM110383, JAXUCZ010000015
      UniProtKB/TrEMBL
      A6K076
      Conserved Domains (1) summary
      pfam05615
      Location:1 → 87
      THOC7; Tho complex subunit 7

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      13692855..13707692
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006251724.4 → XP_006251786.3  THO complex subunit 7 homolog isoform X1

      UniProtKB/TrEMBL
      A0A8I6ABD9
      Related
      ENSRNOP00000090671.1, ENSRNOT00000096506.2
      Conserved Domains (1) summary
      pfam05615
      Location:66 → 198
      THOC7; Tho complex subunit 7

    2. XM_006251725.4 → XP_006251787.2  THO complex subunit 7 homolog isoform X2

      UniProtKB/TrEMBL
      A0A0G2K0L6, A6K075
      Related
      ENSRNOP00000071495.3, ENSRNOT00000083787.3

    3. XM_017599648.3 → XP_017455137.1  THO complex subunit 7 homolog isoform X3

      UniProtKB/TrEMBL
      A0A0G2JWV8, F1LXS6
      Related
      ENSRNOP00000089405.2, ENSRNOT00000119585.2
    Nucleotide Protein Strain
    Heading Accession and Version

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