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    E2f6 E2F transcription factor 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313978, updated on 9-Dec-2024

    Summary

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    Official Symbol
    E2f6provided by RGD
    Official Full Name
    E2F transcription factor 6provided by RGD
    Primary source
    RGD:631412
    See related
    EnsemblRapid:ENSRNOG00000004449 AllianceGenome:RGD:631412
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to contribute to DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be located in nucleoplasm. Predicted to be part of MLL1 complex and RNA polymerase II transcription regulator complex. Orthologous to human E2F6 (E2F transcription factor 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 503.6), Heart (RPKM 498.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See E2f6 in Genome Data Viewer
    Location:
    6q16
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (45320993..45337437)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (39592224..39608685)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (42092513..42108692)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene lipin 1 Neighboring gene neurotensin receptor 2 Neighboring gene growth regulating estrogen receptor binding 1 Neighboring gene Rho-associated coiled-coil containing protein kinase 2 Neighboring gene solute carrier family 66 member 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Characterisation and regulation of E2F-6 and E2F-6b in the rat heart: a potential target for myocardial regeneration? Movassagh M, et al. J Pharm Pharmacol, 2006 Jan. PMID 16393466
    2. Analysis of the relevance of e2fs and their target genes with rat liver regeneration. Dong HM, et al. Indian J Gastroenterol, 2008 Jan-Feb. PMID 18541936
    3. E2F-6, a member of the E2F family that can behave as a transcriptional repressor. Trimarchi JM, et al. Proc Natl Acad Sci U S A, 1998 Mar 17. PMID 9501179, Free PMC Article
    4. A role for E2F6 in distinguishing G1/S- and G2/M-specific transcription. Giangrande PH, et al. Genes Dev, 2004 Dec 1. PMID 15574595, Free PMC Article
    5. PHC3, a component of the hPRC-H complex, associates with E2F6 during G0 and is lost in osteosarcoma tumors. Deshpande AM, et al. Oncogene, 2007 Mar 15. PMID 17001316, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. E2F transcription factor genes and their 34 target genes have a role in liver regeneration.
      Title: Analysis of the relevance of e2fs and their target genes with rat liver regeneration.
    2. isolation and characterization of E2F6 and splice variant named E2F6b in cardiomyocytes as down-reg. in neonate and up-reg. in development of cardiomyocyte hypertrophy
      Title: Characterisation and regulation of E2F-6 and E2F-6b in the rat heart: a potential target for myocardial regeneration?
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of MLL1 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of RNA polymerase II transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RNA polymerase II transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    transcription factor E2F6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100717.2 → NP_001094187.1  transcription factor E2F6

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      D4ACR8, Q80ZB0
      Related
      ENSRNOP00000057241.5, ENSRNOT00000060499.6
      Conserved Domains (2) summary
      cd14660
      Location:139 → 239
      E2F_DD; Dimerization domain of E2F transcription factors
      pfam02319
      Location:65 → 128
      E2F_TDP; E2F/DP family winged-helix DNA-binding domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      45320993..45337437
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039112208.2 → XP_038968136.1  transcription factor E2F6 isoform X2

      Conserved Domains (2) summary
      cd14660
      Location:87 → 187
      E2F_DD; Dimerization domain of E2F transcription factors
      pfam02319
      Location:13 → 76
      E2F_TDP; E2F/DP family winged-helix DNA-binding domain

    2. XM_039112207.2 → XP_038968135.1  transcription factor E2F6 isoform X1

      UniProtKB/TrEMBL
      D4ACR8
      Conserved Domains (2) summary
      cd14660
      Location:104 → 204
      E2F_DD; Dimerization domain of E2F transcription factors
      pfam02319
      Location:30 → 93
      E2F_TDP; E2F/DP family winged-helix DNA-binding domain

    3. XM_006239913.5 → XP_006239975.1  transcription factor E2F6 isoform X1

      UniProtKB/TrEMBL
      D4ACR8
      Related
      ENSRNOP00000076801.1, ENSRNOT00000096820.2
      Conserved Domains (2) summary
      cd14660
      Location:104 → 204
      E2F_DD; Dimerization domain of E2F transcription factors
      pfam02319
      Location:30 → 93
      E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    Nucleotide Protein Strain
    Heading Accession and Version

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