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    Stk35 serine/threonine kinase 35 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311419, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Stk35provided by RGD
    Official Full Name
    serine/threonine kinase 35provided by RGD
    Primary source
    RGD:1310247
    See related
    EnsemblRapid:ENSRNOG00000006002 AllianceGenome:RGD:1310247
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Stk35l1
    Summary
    Predicted to enable eukaryotic translation initiation factor 2alpha kinase activity. Predicted to be involved in regulation of translational initiation. Predicted to be located in nuclear body. Predicted to be active in cytoplasm and nucleus. Orthologous to human STK35 (serine/threonine kinase 35). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 48.9), Adrenal (RPKM 48.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Stk35 in Genome Data Viewer
    Location:
    3q36
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (137465884..137498554)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (117016819..117049131)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (122307976..122340205)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120101661 Neighboring gene prodynorphin Neighboring gene ribosomal protein L22-like 2 Neighboring gene uncharacterized LOC134486151 Neighboring gene ribosomal protein L12, pseudogene 5 Neighboring gene uncharacterized LOC134486152

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identifying and characterizing a novel protein kinase STK35L1 and deciphering its orthologs and close-homologs in vertebrates. Goyal P, et al. PLoS One, 2009 Sep 16. PMID 19756140, Free PMC Article
    2. A germline-specific class of small RNAs binds mammalian Piwi proteins. Girard A, et al. Nature, 2006 Jul 13. PMID 16751776
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of G2/M transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of G2/MI transition of meiotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase 35
    NP_001101243.1
    XP_006235036.1
    XP_006235037.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107773.1 → NP_001101243.1  serine/threonine-protein kinase 35

      See identical proteins and their annotated locations for NP_001101243.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473949
      UniProtKB/TrEMBL
      A6HQ70, D3ZKU3
      Related
      ENSRNOP00000008071.5, ENSRNOT00000008071.7
      Conserved Domains (2) summary
      smart00220
      Location:272 → 593
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd13977
      Location:271 → 599
      STKc_PDIK1L; Catalytic domain of the Serine/Threonine kinase, PDLIM1 interacting kinase 1 like

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      137465884..137498554
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006234975.5 → XP_006235037.1  serine/threonine-protein kinase 35 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AKS4
      Related
      ENSRNOP00000093642.1, ENSRNOT00000117385.2
      Conserved Domains (1) summary
      cl21453
      Location:271 → 369
      PKc_like; Protein Kinases, catalytic domain

    2. XM_006234974.5 → XP_006235036.1  serine/threonine-protein kinase 35 isoform X1

      Conserved Domains (2) summary
      smart00220
      Location:70 → 391
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd13977
      Location:69 → 397
      STKc_PDIK1L; Catalytic domain of the Serine/Threonine kinase, PDLIM1 interacting kinase 1 like
    Nucleotide Protein Strain
    Heading Accession and Version

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