Tmem163 transmembrane protein 163 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tmem163provided by RGD
Official Full Name: transmembrane protein 163provided by RGD
Primary source: RGD:1306212
See related: EnsemblRapid:ENSRNOG00000003769 AllianceGenome:RGD:1306212
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Sv31; RGD1306212
Summary: Enables zinc ion binding activity. Involved in zinc ion import into synaptic vesicle. Located in early endosome membrane. Is active in synaptic vesicle membrane. Used to study proteinuria. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 25. Orthologous to human TMEM163 (transmembrane protein 163). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 95.1), Lung (RPKM 50.3) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q13

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (41520595..41693938, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (38967913..39141664, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (44166306..44345735, complement)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

that the synaptic vesicle-integral protein SV31 functions as a proton-dependent Zn(2+) transporter
Title: The synaptic vesicle protein SV31 assembles into a dimer and transports Zn(2).
SV31 represents a novel Zn(2+) -binding protein that in PC12 cells is targeted to endosomes and subpopulations of synaptic-like microvesicles
Title: SV31 is a Zn2+-binding synaptic vesicle protein.
identification and characterization of SV31, a novel synaptic vesicle membrane protein of 31 kDa with six putative transmembrane helices that, according to its membrane topology and phylogenetic relation, may function as a vesicular transporter
Title: Identification and characterization of SV31, a novel synaptic vesicle membrane protein and potential transporter.

Submit: New GeneRIF Correction

General gene information

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Markers

d13rat147 (e-PCR)
- UniSTS:120898

RH139058 (e-PCR)
- UniSTS:221144

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables zinc ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in myelination	ISO Inferred from Sequence Orthology more info
involved_in myelination	ISS Inferred from Sequence or Structural Similarity more info
involved_in zinc export across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in zinc export across plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
involved_in zinc ion import into synaptic vesicle	IDA Inferred from Direct Assay more info	PubMed
involved_in zinc ion import into synaptic vesicle	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in early endosome membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in intracellular vesicle	ISO Inferred from Sequence Orthology more info
located_in late endosome membrane	IEA Inferred from Electronic Annotation more info
located_in lysosomal membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in synaptic vesicle membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in synaptic vesicle membrane	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic vesicle membrane	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic vesicle membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: transmembrane protein 163

Names: synaptic vesicle membrane protein of 31 kDa; synaptic vesicle protein of 30 kD

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001110763.2 → NP_001104233.2 transmembrane protein 163

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000013

UniProtKB/Swiss-Prot

A9CMA6

Related

ENSRNOP00000005006.5, ENSRNOT00000005006.6

Conserved Domains (1) summary

pfam01545
Location:100 → 273

Cation_efflux; Cation efflux family