Yes1 YES proto-oncogene 1, Src family tyrosine kinase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Yes1provided by RGD
Official Full Name: YES proto-oncogene 1, Src family tyrosine kinaseprovided by RGD
Primary source: RGD:3977
See related: EnsemblRapid:ENSRNOG00000037227 AllianceGenome:RGD:3977
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Yes; c-Yes; p61-Yes; p60c-yes
Summary: Enables epidermal growth factor receptor binding activity and protein tyrosine kinase activity. Involved in protein autophosphorylation. Is active in glutamatergic synapse and postsynaptic specialization, intracellular component. Orthologous to human YES1 (YES proto-oncogene 1, Src family tyrosine kinase). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Lung (RPKM 157.1), Kidney (RPKM 134.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q38

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (120646657..120753880)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (113200256..113275942)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (121802471..121918906)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

c-Yes was found to promote endocytosed integral membrane blood-testis barrier (BTB) proteins to the pathway of transcytosis and recycling so that internalized proteins could be effectively used to assemble new BTB from the disassembling old BTB.
Title: Differential effects of c-Src and c-Yes on the endocytic vesicle-mediated trafficking events at the Sertoli cell blood-testis barrier: an in vitro study.
c-Yes regulates cell adhesion at the apical ectoplasmic specialization-blood-testis barrier axis.
Title: c-Yes regulates cell adhesion at the apical ectoplasmic specialization-blood-testis barrier axis via its effects on protein recruitment and distribution.
In rat pancreatic acini, the SFK member Yes is expressed and activated by CCK and other gastrointestinal hormones/neurotransmitters.
Title: The Src kinase Yes is activated in pancreatic acinar cells by gastrointestinal hormones/neurotransmitters, but not pancreatic growth factors, which stimulate its association with numerous other signaling molecules.
c-Yes regulates blood-testis barrier and apical ectoplasmic specialization integrity by maintaining proper distribution of integral membrane proteins and actin filament organization at these sites
Title: c-Yes regulates cell adhesion at the blood-testis barrier and the apical ectoplasmic specialization in the seminiferous epithelium of rat testes.
Hypoxia enhanced phosphorylation of three srcFK proteins at Tyr-416 (60, 59, and 54 kDa, corresponding to src, fyn, and yes, respectively) and enhanced srcFK-dependent tyrosine phosphorylation of multiple target proteins.
Title: Role of src-family kinases in hypoxic vasoconstriction of rat pulmonary artery.
Yes is activated by cholecystokinin, which stimulates extracellular signal-regulated kinase
Title: Cholecystokinin stimulates extracellular signal-regulated kinase through activation of the epidermal growth factor receptor, Yes, and protein kinase C. Signal amplification at the level of Raf by activation of protein kinase Cepsilon.
Src family kinase Yes triggers hyperosmotic activation of the epidermal growth factor receptor and CD95
Title: The Src family kinase Yes triggers hyperosmotic activation of the epidermal growth factor receptor and CD95.
Yes participates in the regulation of acinar cell actin, probably by interaction with Pyk2.
Title: The tyrosine kinase Yes regulates actin structure and secretion during pancreatic acinar cell damage in rats.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH140391 (e-PCR)
- UniSTS:222466

RH27881 (e-PCR)
- UniSTS:87601

D22S1032 (e-PCR)
- UniSTS:58713

D9Got128 (e-PCR)
- UniSTS:112758

AI323763 (e-PCR)
- UniSTS:179147

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables enzyme binding	IEA Inferred from Electronic Annotation more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables epidermal growth factor receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables histone H2AXY142 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3Y41 kinase activity	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables non-membrane spanning protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables phosphotyrosine residue binding	IEA Inferred from Electronic Annotation more info
enables phosphotyrosine residue binding	ISO Inferred from Sequence Orthology more info
enables protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane transporter binding	IEA Inferred from Electronic Annotation more info
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to platelet-derived growth factor stimulus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to platelet-derived growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to retinoic acid	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to retinoic acid	ISO Inferred from Sequence Orthology more info
involved_in cellular response to transforming growth factor beta stimulus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to transforming growth factor beta stimulus	ISO Inferred from Sequence Orthology more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of peptidyl-tyrosine phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of D-glucose transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of D-glucose transmembrane transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in actin filament	IEA Inferred from Electronic Annotation more info
located_in actin filament	ISO Inferred from Sequence Orthology more info
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in cell junction	ISO Inferred from Sequence Orthology more info
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info
is_active_in postsynaptic specialization, intracellular component	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: tyrosine-protein kinase Yes

Names: Yamagichi sarcoma viral (v-yes-1) oncogene homolog 1; Yamaguchi sarcoma viral (v-yes) oncogene homolog 1; Yamaguchi sarcoma viral oncogene homolog 1

NP_001385513.1

EC 2.7.10.2

NP_001385514.1

EC 2.7.10.2

NP_150640.1

EC 2.7.10.2

XP_063122722.1

EC 2.7.10.2

XP_063122723.1

EC 2.7.10.2

XP_063122724.1

EC 2.7.10.2

XP_063122725.1

EC 2.7.10.2

XP_063122726.1

EC 2.7.10.2

XP_063122727.1

EC 2.7.10.2

XP_063122728.1

EC 2.7.10.2

XP_063122729.1

EC 2.7.10.2

XP_063122730.1

EC 2.7.10.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001398584.1 → NP_001385513.1 tyrosine-protein kinase Yes isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000009

UniProtKB/TrEMBL

A0A8J8XNH3, A6KFB6, Q99PW1

Conserved Domains (3) summary

cd09933
Location:152 → 251

SH2_Src_family; Src homology 2 (SH2) domain found in the Src family of non-receptor tyrosine kinases

cd12007
Location:92 → 149

SH3_Yes; Src homology 3 domain of Yes Protein Tyrosine Kinase

cd05069
Location:262 → 540

PTKc_Yes; Catalytic domain of the Protein Tyrosine Kinase, Yes
NM_001398585.1 → NP_001385514.1 tyrosine-protein kinase Yes isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000009

UniProtKB/TrEMBL

A0A8J8XNH3, A6KFB6, Q99PW1

Related

ENSRNOP00000053094.4, ENSRNOT00000056251.7

Conserved Domains (3) summary

cd09933
Location:152 → 251

SH2_Src_family; Src homology 2 (SH2) domain found in the Src family of non-receptor tyrosine kinases

cd12007
Location:92 → 149

SH3_Yes; Src homology 3 domain of Yes Protein Tyrosine Kinase

cd05069
Location:262 → 540

PTKc_Yes; Catalytic domain of the Protein Tyrosine Kinase, Yes
NM_033298.2 → NP_150640.1 tyrosine-protein kinase Yes isoform 2

See identical proteins and their annotated locations for NP_150640.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000009

UniProtKB/Swiss-Prot

F1LM93

UniProtKB/TrEMBL

F1LM92, Q6AXQ3

Related

ENSRNOP00000072395.3, ENSRNOT00000086534.3

Conserved Domains (4) summary

cd09933
Location:152 → 251

SH2_Src_family; Src homology 2 (SH2) domain found in the Src family of non-receptor tyrosine kinases

cd12007
Location:92 → 149

SH3_Yes; Src homology 3 domain of Yes Protein Tyrosine Kinase

pfam07714
Location:275 → 474

Pkinase_Tyr; Protein tyrosine kinase

cl21453
Location:262 → 478

PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086027.1 Reference GRCr8

Range

120646657..120753880

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063266654.1 → XP_063122724.1 tyrosine-protein kinase Yes isoform X1
XM_063266657.1 → XP_063122727.1 tyrosine-protein kinase Yes isoform X2

UniProtKB/TrEMBL

A0A8J8XNH3, A6KFB6, Q99PW1
XM_063266655.1 → XP_063122725.1 tyrosine-protein kinase Yes isoform X1
XM_063266652.1 → XP_063122722.1 tyrosine-protein kinase Yes isoform X1
XM_063266659.1 → XP_063122729.1 tyrosine-protein kinase Yes isoform X3
XM_063266660.1 → XP_063122730.1 tyrosine-protein kinase Yes isoform X4
XM_063266653.1 → XP_063122723.1 tyrosine-protein kinase Yes isoform X1
XM_063266658.1 → XP_063122728.1 tyrosine-protein kinase Yes isoform X2

UniProtKB/TrEMBL

A0A8J8XNH3, A6KFB6, Q99PW1
XM_063266656.1 → XP_063122726.1 tyrosine-protein kinase Yes isoform X1