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    Dtx2 deltex E3 ubiquitin ligase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 304591, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Dtx2provided by RGD
    Official Full Name
    deltex E3 ubiquitin ligase 2provided by RGD
    Primary source
    RGD:1561790
    See related
    EnsemblRapid:ENSRNOG00000001432 AllianceGenome:RGD:1561790
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in Notch signaling pathway and protein ubiquitination. Predicted to be located in nuclear membrane. Predicted to be active in nucleoplasm. Orthologous to human DTX2 (deltex E3 ubiquitin ligase 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 51.4), Thymus (RPKM 49.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dtx2 in Genome Data Viewer
    Location:
    12q12
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (26279899..26319541, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (20643289..20682908, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (23687958..23727594, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene uroplakin 3B like 1 Neighboring gene uncharacterized LOC120095913 Neighboring gene uroplakin 3B Neighboring gene U6 spliceosomal RNA Neighboring gene zona pellucida glycoprotein 3 Neighboring gene scavenger receptor cysteine rich family member with 4 domains Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Murine homologs of deltex define a novel gene family involved in vertebrate Notch signaling and neurogenesis. Kishi N, et al. Int J Dev Neurosci, 2001 Feb. PMID 11226752
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Notch signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within Notch signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    probable E3 ubiquitin-protein ligase DTX2
    Names
    deltex 2 homolog
    deltex 2, E3 ubiquitin ligase
    deltex homolog 2
    protein deltex-2
    NP_001100627.1
    XP_006249221.1
    XP_038945454.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107157.2 → NP_001100627.1  probable E3 ubiquitin-protein ligase DTX2

      See identical proteins and their annotated locations for NP_001100627.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/TrEMBL
      A6J094, B2RYD5, G3V658
      Related
      ENSRNOP00000001950.5, ENSRNOT00000001950.8
      Conserved Domains (4) summary
      smart00678
      Location:21 → 105
      WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
      PHA03247
      Location:204 → 392
      PHA03247; large tegument protein UL36; Provisional
      cd16672
      Location:408 → 479
      RING-H2_DTX2; RING finger, H2 subclass, found in E3 ubiquitin-protein ligase Deltex2 (DTX2) and similar proteins
      pfam18102
      Location:477 → 611
      DTC; Deltex C-terminal domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      26279899..26319541 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006249159.4 → XP_006249221.1  probable E3 ubiquitin-protein ligase DTX2 isoform X2

      See identical proteins and their annotated locations for XP_006249221.1

      UniProtKB/TrEMBL
      A0A8I5ZTQ2, A6J092, B2RYD5
      Related
      ENSRNOP00000080750.1, ENSRNOT00000110093.2
      Conserved Domains (3) summary
      smart00678
      Location:21 → 105
      WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
      cd09633
      Location:432 → 564
      Deltex_C; Domain found at the C-terminus of deltex-like
      cd00162
      Location:362 → 425
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    2. XM_039089526.2 → XP_038945454.1  probable E3 ubiquitin-protein ligase DTX2 isoform X1

      UniProtKB/TrEMBL
      A6J094, B2RYD5, G3V658
      Conserved Domains (4) summary
      smart00678
      Location:21 → 105
      WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
      PHA03247
      Location:204 → 392
      PHA03247; large tegument protein UL36; Provisional
      cd16672
      Location:408 → 479
      RING-H2_DTX2; RING finger, H2 subclass, found in E3 ubiquitin-protein ligase Deltex2 (DTX2) and similar proteins
      pfam18102
      Location:477 → 611
      DTC; Deltex C-terminal domain
    Nucleotide Protein Strain
    Heading Accession and Version

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