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    Pcgf3 polycomb group ring finger 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305624, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Pcgf3provided by RGD
    Official Full Name
    polycomb group ring finger 3provided by RGD
    Primary source
    RGD:1311479
    See related
    AllianceGenome:RGD:1311479
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Rnf3
    Summary
    Predicted to enable histone H2AK119 ubiquitin ligase activity. Predicted to be involved in random inactivation of X chromosome and regulation of transcription by RNA polymerase II. Predicted to be located in X chromosome and nucleoplasm. Predicted to be part of PRC1 complex. Orthologous to human PCGF3 (polycomb group ring finger 3). [provided by Alliance of Genome Resources, Nov 2024]
    Annotation information
    Annotation category: suggests misassembly
    Annotation category: partial on reference assembly
    Expression
    Biased expression in Thymus (RPKM 102.3), Lung (RPKM 93.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pcgf3 in Genome Data Viewer
    Location:
    14p22
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (1381976..1436709, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (1237594..1291717, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (2247805..2297155, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene cyclin G associated kinase Neighboring gene U6 spliceosomal RNA Neighboring gene complexin 1 Neighboring gene solute carrier family 49 member 3 Neighboring gene ATP synthase membrane subunit e

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. PCGF3/5-PRC1 initiates Polycomb recruitment in X chromosome inactivation. Almeida M, et al. Science, 2017 Jun 9. PMID 28596365, Free PMC Article
    2. PRC1 complex diversity: where is it taking us? Gil J, et al. Trends Cell Biol, 2014 Nov. PMID 25065329
    3. Occupying chromatin: Polycomb mechanisms for getting to genomic targets, stopping transcriptional traffic, and staying put. Simon JA, et al. Mol Cell, 2013 Mar 7. PMID 23473600, Free PMC Article
    4. Interaction proteomics analysis of polycomb proteins defines distinct PRC1 complexes in mammalian cells. Vandamme J, et al. Mol Cell Proteomics, 2011 Apr. PMID 21282530, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables histone H2AK119 ubiquitin ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in random inactivation of X chromosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of PRC1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of PcG protein complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in X chromosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    polycomb group RING finger protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107245.2 → NP_001100715.2  polycomb group RING finger protein 3

      See identical proteins and their annotated locations for NP_001100715.2

      Status: PROVISIONAL

      Source sequence(s)
      BC167000
      UniProtKB/TrEMBL
      B2RZ26, F7EV63
      Conserved Domains (2) summary
      cd16735
      Location:14 → 60
      RING-HC_PCGF3; RING finger found in polycomb group RING finger protein 3 (PCGF3) and similar proteins
      cd17083
      Location:153 → 235
      RAWUL_PCGF3; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 3 (PCGF3) and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      1381976..1436709 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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