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    Shroom1 shroom family member 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287285, updated on 2-Nov-2024

    Summary

    Official Symbol
    Shroom1provided by RGD
    Official Full Name
    shroom family member 1provided by RGD
    Primary source
    RGD:1308066
    See related
    EnsemblRapid:ENSRNOG00000007431 AllianceGenome:RGD:1308066
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1308066
    Summary
    Predicted to enable actin filament binding activity and myosin II binding activity. Predicted to be involved in actin filament bundle assembly and cell morphogenesis. Predicted to be located in microtubule. Predicted to be active in several cellular components, including adherens junction; apical junction complex; and apical plasma membrane. Orthologous to human SHROOM1 (shroom family member 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Liver (RPKM 56.1), Brain (RPKM 14.0) and 6 other tissues See more
    Orthologs
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    Genomic context

    See Shroom1 in Genome Data Viewer
    Location:
    10q22
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (38121971..38134832)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (37621149..37631895)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (38814420..38825159)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene liver enriched antimicrobial peptide 2 Neighboring gene ubiquinol-cytochrome c reductase, complex III subunit VII Neighboring gene growth differentiation factor 9 Neighboring gene sosondowah ankyrin repeat domain family member A Neighboring gene septin 8

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables actin filament binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables myosin II binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in actin filament bundle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in actin filament bundle assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in adherens junction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in apical junction complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in apical plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cortical actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      38121971..38134832
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006246367.5XP_006246429.1  protein Shroom1 isoform X1

      See identical proteins and their annotated locations for XP_006246429.1

      UniProtKB/TrEMBL
      A0A8I5ZRQ2, M0RB44
      Related
      ENSRNOP00000081463.2, ENSRNOT00000113885.2
      Conserved Domains (2) summary
      pfam08687
      Location:552829
      ASD2; Apx/Shroom domain ASD2
      pfam08688
      Location:150273
      ASD1; Apx/Shroom domain ASD1
    2. XM_039087192.2XP_038943120.1  protein Shroom1 isoform X2

      UniProtKB/TrEMBL
      M0RB44
      Conserved Domains (2) summary
      pfam08687
      Location:552817
      ASD2; Apx/Shroom domain ASD2
      pfam08688
      Location:150275
      ASD1; Apx/Shroom domain ASD1