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    Ppm1j protein phosphatase, Mg2+/Mn2+ dependent, 1J [ Rattus norvegicus (Norway rat) ]

    Gene ID: 295341, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ppm1jprovided by RGD
    Official Full Name
    protein phosphatase, Mg2+/Mn2+ dependent, 1Jprovided by RGD
    Primary source
    RGD:1359104
    See related
    EnsemblRapid:ENSRNOG00000012481 AllianceGenome:RGD:1359104
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity. Predicted to be involved in signal transduction. Predicted to act upstream of or within protein dephosphorylation. Predicted to be active in mitochondrion. Orthologous to human PPM1J (protein phosphatase, Mg2+/Mn2+ dependent 1J). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 96.5), Testes (RPKM 61.9) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ppm1j in Genome Data Viewer
    Location:
    2q34
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (194966854..194972228)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (192278597..192283883)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (207263307..207268601)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108350080 Neighboring gene uncharacterized LOC134485945 Neighboring gene TAFA chemokine like family member 3 Neighboring gene ras homolog family member C Neighboring gene Mov10 RNA helicase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A novel protein phosphatase 2C family member (PP2Czeta) is able to associate with ubiquitin conjugating enzyme 9. Kashiwaba M, et al. FEBS Lett, 2003 Mar 13. PMID 12633878
    2. Molecular cloning of PP2Ceta, a novel member of the protein phosphatase 2C family. Komaki K, et al. Biochim Biophys Acta, 2003 Nov 30. PMID 14654243
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC95205

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables MAP kinase serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calmodulin-dependent protein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS140 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein phosphatase 1J
    Names
    PP2C-zeta
    protein phosphatase 2C zeta
    NP_001005540.1
    XP_008759602.1
    XP_008759603.1
    XP_063137710.1
    XP_063137711.1
    XP_063137712.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001005540.1 → NP_001005540.1  protein phosphatase 1J

      See identical proteins and their annotated locations for NP_001005540.1

      Status: PROVISIONAL

      Source sequence(s)
      BC082053
      UniProtKB/Swiss-Prot
      Q641Y6
      UniProtKB/TrEMBL
      A0A8I5ZXT1, A6K3P4
      Related
      ENSRNOP00000079348.2, ENSRNOT00000110381.2
      Conserved Domains (1) summary
      cd00143
      Location:105 → 496
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      194966854..194972228
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063281641.1 → XP_063137711.1  protein phosphatase 1J isoform X4

    2. XM_008761381.4 → XP_008759603.1  protein phosphatase 1J isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZXT1
      Related
      ENSRNOP00000082364.2, ENSRNOT00000118224.2
      Conserved Domains (1) summary
      cd00143
      Location:123 → 478
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...

    3. XM_008761380.4 → XP_008759602.1  protein phosphatase 1J isoform X1

      UniProtKB/TrEMBL
      A0A0H2UHJ9, A0A8I5ZXT1
      Related
      ENSRNOP00000016833.5, ENSRNOT00000016833.8
      Conserved Domains (1) summary
      cd00143
      Location:123 → 514
      PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...

    4. XM_063281642.1 → XP_063137712.1  protein phosphatase 1J isoform X5

    5. XM_063281640.1 → XP_063137710.1  protein phosphatase 1J isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZMI9, A0A8I5ZXT1

    RNA

    1. XR_005500269.2 RNA Sequence

    2. XR_005500270.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q641Y6.1 GenPept UniProtKB/Swiss-Prot:Q641Y6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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