Dus1l dihydrouridine synthase 1-like [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dus1lprovided by RGD
Official Full Name: dihydrouridine synthase 1-likeprovided by RGD
Primary source: RGD:708389
See related: EnsemblRapid:ENSRNOG00000047905 AllianceGenome:RGD:708389
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: x85; Pp3111
Summary: Predicted to enable tRNA dihydrouridine synthase activity. Predicted to be involved in tRNA dihydrouridine synthesis. Orthologous to human DUS1L (dihydrouridine synthase 1 like). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 132.8), Thymus (RPKM 123.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q32.3

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (106553841..106560977, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (106055519..106062656, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (109972018..109979113, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables flavin adenine dinucleotide binding	IEA Inferred from Electronic Annotation more info
enables tRNA dihydrouridine synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables tRNA dihydrouridine synthase activity	IEA Inferred from Electronic Annotation more info
enables tRNA-dihydrouridine16 synthase activity	ISO Inferred from Sequence Orthology more info
enables tRNA-dihydrouridine16 synthase activity	ISS Inferred from Sequence or Structural Similarity more info
enables tRNA-dihydrouridine17 synthase activity	ISO Inferred from Sequence Orthology more info
enables tRNA-dihydrouridine17 synthase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in tRNA dihydrouridine synthesis	IEA Inferred from Electronic Annotation more info
involved_in tRNA dihydrouridine synthesis	ISO Inferred from Sequence Orthology more info
involved_in tRNA dihydrouridine synthesis	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like

Names: embryo-related protein; liver regeneration-related protein LRRG08/LRRG09

NP_742015.2

EC 1.3.1.88

XP_006247937.2

EC 1.3.1.88

XP_038941132.1

EC 1.3.1.88

XP_038941133.1

EC 1.3.1.88

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_172018.2 → NP_742015.2 tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

Q8K582

Related

ENSRNOP00000067257.2, ENSRNOT00000073956.4

Conserved Domains (2) summary

TIGR01623
Location:396 → 431

put_zinc_LRP1; putative zinc finger domain, LRP1 type

cd02801
Location:18 → 250

DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

106553841..106560977 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006247875.4 → XP_006247937.2 tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform X1

UniProtKB/Swiss-Prot

Q8K582
XM_039085204.2 → XP_038941132.1 tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform X2

UniProtKB/TrEMBL

A6HLK0

Conserved Domains (2) summary

TIGR01623
Location:234 → 269

put_zinc_LRP1; putative zinc finger domain, LRP1 type

cd02801
Location:1 → 88

DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...
XM_039085205.2 → XP_038941133.1 tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like isoform X2

UniProtKB/TrEMBL

A6HLK0

Conserved Domains (2) summary

TIGR01623
Location:234 → 269

put_zinc_LRP1; putative zinc finger domain, LRP1 type

cd02801
Location:1 → 88

DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...