Cdh3 cadherin 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cdh3provided by RGD
Official Full Name: cadherin 3provided by RGD
Primary source: RGD:621089
See related: EnsemblRapid:ENSRNOG00000020129 AllianceGenome:RGD:621089
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable beta-catenin binding activity and cadherin binding activity. Involved in response to xenobiotic stimulus. Predicted to be located in cell junction and plasma membrane. Predicted to be part of catenin complex. Predicted to be active in adherens junction and cytoplasm. Human ortholog(s) of this gene implicated in congenital hypotrichosis with juvenile macular dystrophy and ectodermal dysplasia, ectrodactyly, and macular dystrophy syndrome. Orthologous to human CDH3 (cadherin 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Lung (RPKM 40.1), Kidney (RPKM 31.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19q12

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (51303414..51353900)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (34393596..34444084)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (38668957..38719801)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Diabetic proteinuria is mediated by the activation of 12-LO pathway that is partially attributed to the decreased glomerular P-cadherin expression.
Title: Role of 12-lipoxygenase in decreasing P-cadherin and increasing angiotensin II type 1 receptor expression according to glomerular size in type 2 diabetic rats.
expressed throughout prepubertal ovarian development
Title: Expression and localization of P-, K-, and OB-cadherin in the prepubertal rat ovary.
Comparison of the expression patterns of E- and P-cadherins during wound healing of the epidermis strongly suggests that these two cadherins play distinct roles in re-epithelialization.
Title: Expression of P-cadherin distinct from that of E-cadherin in re-epithelialization in neonatal rat skin.

Submit: New GeneRIF Correction

General gene information

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Markers

AI010270 (e-PCR)
- UniSTS:249927

Cdh3 (e-PCR), detects polymorphism
- UniSTS:545910

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables beta-catenin binding	IBA Inferred from Biological aspect of Ancestor more info
enables cadherin binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in adherens junction organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in cell-cell adhesion mediated by cadherin	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell junction assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in hair cycle process	ISO Inferred from Sequence Orthology more info
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IEA Inferred from Electronic Annotation more info
involved_in keratinization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of timing of catagen	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within_negative_effect negative regulation of transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_positive_effect positive regulation of insulin-like growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of keratinocyte proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of melanin biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of melanosome transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tyrosinase activity	ISO Inferred from Sequence Orthology more info
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in retina homeostasis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in adherens junction	IBA Inferred from Biological aspect of Ancestor more info
located_in adherens junction	ISO Inferred from Sequence Orthology more info
part_of catenin complex	IBA Inferred from Biological aspect of Ancestor more info
located_in cell junction	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cadherin-3

Names: cadherin 3, type 1, P-cadherin (placental)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053938.2 → NP_446390.2 cadherin-3 precursor

See identical proteins and their annotated locations for NP_446390.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000019

UniProtKB/TrEMBL

A6IYX2, F1LMI3

Related

ENSRNOP00000027273.8, ENSRNOT00000027273.9

Conserved Domains (3) summary

cd11304
Location:211 → 316

Cadherin_repeat; Cadherin tandem repeat domain

pfam01049
Location:680 → 817

Cadherin_C; Cadherin cytoplasmic region

cl09101
Location:103 → 203

E_set; Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086037.1 Reference GRCr8

Range

51303414..51353900

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006255559.5 → XP_006255621.1 cadherin-3 isoform X1

Related

ENSRNOP00000105187.1, ENSRNOT00000131260.1

Conserved Domains (3) summary

cd11304
Location:207 → 312

Cadherin_repeat; Cadherin tandem repeat domain

pfam01049
Location:676 → 813

Cadherin_C; Cadherin cytoplasmic region

cl09101
Location:99 → 199

E_set; Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus