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    Txnl4b thioredoxin-like 4B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 292008, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Txnl4bprovided by RGD
    Official Full Name
    thioredoxin-like 4Bprovided by RGD
    Primary source
    RGD:1305127
    See related
    EnsemblRapid:ENSRNOG00000021379 AllianceGenome:RGD:1305127
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1305127
    Summary
    Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of U4/U6 x U5 tri-snRNP complex; U5 snRNP; and spliceosomal complex. Orthologous to human TXNL4B (thioredoxin like 4B). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 41.1), Kidney (RPKM 40.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Txnl4b in Genome Data Viewer
    Location:
    19q12
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (54439686..54449777)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (37530157..37539827)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (42101081..42110223, complement)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134483362 Neighboring gene polyamine modulated factor 1 binding protein 1 Neighboring gene uncharacterized LOC134483363 Neighboring gene DEAH-box helicase 38 Neighboring gene haptoglobin Neighboring gene dihydroorotate dehydrogenase Neighboring gene polycystin 1 like 3, transient receptor potential channel interacting Neighboring gene IST1 factor associated with ESCRT-III

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC109322

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in mRNA splicing, via spliceosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of U4/U6 x U5 tri-snRNP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U5 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    thioredoxin-like protein 4B
    Names
    Dim1-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013891.2 → NP_001013913.1  thioredoxin-like protein 4B isoform 1

      See identical proteins and their annotated locations for NP_001013913.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/TrEMBL
      F7FL88, Q5FVI5
      Conserved Domains (1) summary
      cd02986
      Location:10 → 123
      DLP; Dim1 family, Dim1-like protein (DLP) subfamily; DLP is a novel protein which shares 38% sequence identity to Dim1. Like Dim1, it is also implicated in pre-mRNA splicing and cell cycle progression. DLP is located in the nucleus and has been shown to ...

    2. NM_001434407.1 → NP_001421336.1  thioredoxin-like protein 4B isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019

    RNA

    1. NR_197783.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      54439686..54449777
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006255579.5 → XP_006255641.1  thioredoxin-like protein 4B isoform X1

      UniProtKB/TrEMBL
      F7FL88, Q5FVI5
      Related
      ENSRNOP00000030193.3, ENSRNOT00000034676.6
      Conserved Domains (1) summary
      cd02986
      Location:10 → 123
      DLP; Dim1 family, Dim1-like protein (DLP) subfamily; DLP is a novel protein which shares 38% sequence identity to Dim1. Like Dim1, it is also implicated in pre-mRNA splicing and cell cycle progression. DLP is located in the nucleus and has been shown to ...

    2. XM_017601235.3 → XP_017456724.1  thioredoxin-like protein 4B isoform X2

      Conserved Domains (1) summary
      cl00388
      Location:1 → 69
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

    3. XM_063277930.1 → XP_063134000.1  thioredoxin-like protein 4B isoform X1

      UniProtKB/TrEMBL
      F7FL88, Q5FVI5

    4. XM_063277931.1 → XP_063134001.1  thioredoxin-like protein 4B isoform X2

    RNA

    1. XR_361828.5 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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