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    Tubgcp3 tubulin gamma complex component 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 306599, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tubgcp3provided by RGD
    Official Full Name
    tubulin gamma complex component 3provided by RGD
    Primary source
    RGD:1305726
    See related
    EnsemblRapid:ENSRNOG00000017085 AllianceGenome:RGD:1305726
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable gamma-tubulin binding activity. Predicted to contribute to microtubule minus-end binding activity. Predicted to be involved in meiotic cell cycle; microtubule cytoskeleton organization; and mitotic cell cycle. Predicted to be located in cytoplasm and microtubule cytoskeleton. Predicted to be part of gamma-tubulin complex. Orthologous to human TUBGCP3 (tubulin gamma complex component 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 110.9), Adrenal (RPKM 91.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tubgcp3 in Genome Data Viewer
    Location:
    16q12.5
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (83553950..83614626)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (76851859..76912499)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (82184362..82245041)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene ATPase phospholipid transporting 11A Neighboring gene uncharacterized LOC102548949 Neighboring gene uncharacterized LOC134482533 Neighboring gene sperm acrosome associated 7 Neighboring gene uncharacterized LOC120097560

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Characterization of the human homologue of the yeast spc98p and its association with gamma-tubulin. Tassin AM, et al. J Cell Biol, 1998 May 4. PMID 9566969, Free PMC Article
    2. Proteomic analysis of TRPC5- and TRPC6-binding partners reveals interaction with the plasmalemmal Na(+)/K(+)-ATPase. Goel M, et al. Pflugers Arch, 2005 Oct. PMID 16025302
    3. Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. Jakobsen L, et al. EMBO J, 2011 Apr 20. PMID 21399614, Free PMC Article
    4. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables gamma-tubulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables gamma-tubulin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to microtubule minus-end binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoplasmic microtubule organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in meiotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule nucleation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spindle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in centriole ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of gamma-tubulin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in polar microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    gamma-tubulin complex component 3
    Names
    tubulin, gamma complex associated protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107323.2 → NP_001100793.2  gamma-tubulin complex component 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      A0A0G2JUU7, A0A8I6GLP6
      Related
      ENSRNOP00000069236.1, ENSRNOT00000089329.3
      Conserved Domains (2) summary
      pfam04130
      Location:550 → 881
      Spc97_Spc98; Spc97 / Spc98 family
      pfam17681
      Location:246 → 547
      GCP_N_terminal; Gamma tubulin complex component N-terminal

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      83553950..83614626
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063275461.1 → XP_063131531.1  gamma-tubulin complex component 3 isoform X1

      UniProtKB/TrEMBL
      A0A8I6GLP6

    2. XM_006253441.5 → XP_006253503.1  gamma-tubulin complex component 3 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AUJ2, A0A8I6GLP6
      Related
      ENSRNOP00000096034.1, ENSRNOT00000110771.2
      Conserved Domains (1) summary
      pfam04130
      Location:212 → 722
      Spc97_Spc98; Spc97 / Spc98 family
    Nucleotide Protein Strain
    Heading Accession and Version

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