Tnrc6a trinucleotide repeat containing adaptor 6A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tnrc6aprovided by RGD
Official Full Name: trinucleotide repeat containing adaptor 6Aprovided by RGD
Primary source: RGD:1307268
See related: EnsemblRapid:ENSRNOG00000024737 AllianceGenome:RGD:1307268
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Tnrc6
Summary: Predicted to enable RNA binding activity. Predicted to be involved in P-body assembly; miRNA-mediated gene silencing by inhibition of translation; and positive regulation of nuclear-transcribed mRNA poly(A) tail shortening. Predicted to act upstream of or within cellular response to starvation and endoderm development. Predicted to be located in Golgi apparatus. Predicted to be part of RISC complex. Predicted to be active in P-body and nucleoplasm. Human ortholog(s) of this gene implicated in familial adult myoclonic epilepsy 6. Orthologous to human TNRC6A (trinucleotide repeat containing adaptor 6A). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Adrenal (RPKM 150.0), Lung (RPKM 137.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q36

Exon count:: 30

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (186992457..187146764)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (177561898..177715669)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (192991584..193146403)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Distinct temporal expression of the GW182 paralog TNRC6A in neurons regulates dendritic arborization.
Title: Distinct temporal expression of the GW182 paralog TNRC6A in neurons regulates dendritic arborization.

Submit: New GeneRIF Correction

General gene information

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Markers

RH130254 (e-PCR)
- UniSTS:213541

RH143060 (e-PCR)
- UniSTS:232307

L17913 (e-PCR)
- UniSTS:60532

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in P-body assembly	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
acts_upstream_of_or_within cellular response to starvation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within endoderm development	ISO Inferred from Sequence Orthology more info
involved_in miRNA-mediated gene silencing by inhibition of translation	ISO Inferred from Sequence Orthology more info
involved_in miRNA-mediated post-transcriptional gene silencing	IBA Inferred from Biological aspect of Ancestor more info
involved_in miRNA-mediated post-transcriptional gene silencing	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
is_active_in P-body	IBA Inferred from Biological aspect of Ancestor more info
is_active_in P-body	ISO Inferred from Sequence Orthology more info
located_in P-body	ISO Inferred from Sequence Orthology more info
part_of RISC complex	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	TAS Traceable Author Statement more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: trinucleotide repeat-containing gene 6A protein

Names: trinucleotide repeat containing 6; trinucleotide repeat containing 6a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001395157.2 → NP_001382086.1 trinucleotide repeat-containing gene 6A protein

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A0A8I6GAR2, F1M9Y8

Related

ENSRNOP00000083407.1, ENSRNOT00000096111.2

Conserved Domains (5) summary

pfam10427
Location:1078 → 1203

Ago_hook; Argonaute hook

pfam12938
Location:1298 → 1483

M_domain; M domain of GW182

pfam16608
Location:1508 → 1769

TNRC6-PABC_bdg; TNRC6-PABC binding domain

cd12711
Location:1777 → 1868

RRM_TNRC6A; RNA recognition motif (RRM) found in vertebrate GW182 autoantigen

NF033849
Location:604 → 863

ser_rich_anae_1; serine-rich protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

186992457..187146764

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008759747.4 → XP_008757969.1 trinucleotide repeat-containing gene 6A protein isoform X1

UniProtKB/TrEMBL

F1M9Y8

Conserved Domains (4) summary

cd12711
Location:1791 → 1873

RRM_TNRC6A; RNA recognition motif in vertebrate GW182 autoantigen

pfam10427
Location:1081 → 1212

Ago_hook; Argonaute hook

pfam12938
Location:1307 → 1492

M_domain; M domain of GW182

pfam16608
Location:1515 → 1790

TNRC6-PABC_bdg; TNRC6-PABC binding domain
XM_017589208.3 → XP_017444697.1 trinucleotide repeat-containing gene 6A protein isoform X3

UniProtKB/TrEMBL

F1M9Y8
XM_017589209.3 → XP_017444698.1 trinucleotide repeat-containing gene 6A protein isoform X6

UniProtKB/TrEMBL

A0A8I6ASC0

Related

ENSRNOP00000107027.1, ENSRNOT00000145881.1

Conserved Domains (4) summary

cd12711
Location:1742 → 1824

RRM_TNRC6A; RNA recognition motif in vertebrate GW182 autoantigen

pfam10427
Location:1081 → 1212

Ago_hook; Argonaute hook

pfam12938
Location:1292 → 1443

M_domain; M domain of GW182

pfam16608
Location:1466 → 1741

TNRC6-PABC_bdg; TNRC6-PABC binding domain
XM_063263201.1 → XP_063119271.1 trinucleotide repeat-containing gene 6A protein isoform X9
XM_008759749.4 → XP_008757971.1 trinucleotide repeat-containing gene 6A protein isoform X2

UniProtKB/TrEMBL

F1M9Y8

Conserved Domains (4) summary

cd12711
Location:1780 → 1862

RRM_TNRC6A; RNA recognition motif in vertebrate GW182 autoantigen

pfam10427
Location:1081 → 1201

Ago_hook; Argonaute hook

pfam12938
Location:1296 → 1481

M_domain; M domain of GW182

pfam16608
Location:1504 → 1779

TNRC6-PABC_bdg; TNRC6-PABC binding domain
XM_039078265.2 → XP_038934193.1 trinucleotide repeat-containing gene 6A protein isoform X7

UniProtKB/TrEMBL

F1M9Y8

Conserved Domains (5) summary

pfam10427
Location:1034 → 1159

Ago_hook; Argonaute hook

pfam12938
Location:1254 → 1439

M_domain; M domain of GW182

pfam16608
Location:1464 → 1725

TNRC6-PABC_bdg; TNRC6-PABC binding domain

cd12711
Location:1733 → 1824

RRM_TNRC6A; RNA recognition motif (RRM) found in vertebrate GW182 autoantigen

NF033849
Location:560 → 819

ser_rich_anae_1; serine-rich protein
XM_063263199.1 → XP_063119269.1 trinucleotide repeat-containing gene 6A protein isoform X8
XM_063263213.1 → XP_063119283.1 trinucleotide repeat-containing gene 6A protein isoform X10
XM_063263192.1 → XP_063119262.1 trinucleotide repeat-containing gene 6A protein isoform X4
XM_063263204.1 → XP_063119274.1 trinucleotide repeat-containing gene 6A protein isoform X10
XM_063263194.1 → XP_063119264.1 trinucleotide repeat-containing gene 6A protein isoform X5
XM_063263221.1 → XP_063119291.1 trinucleotide repeat-containing gene 6A protein isoform X10

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001107549.2: Suppressed sequence

Description

NM_001107549.2: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.