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    Zfp609 zinc finger protein 609 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363412, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zfp609provided by RGD
    Official Full Name
    zinc finger protein 609provided by RGD
    Primary source
    RGD:1561651
    See related
    EnsemblRapid:ENSRNOG00000015977 AllianceGenome:RGD:1561651
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Znf609; RGD1561651
    Summary
    Predicted to enable promoter-specific chromatin binding activity. Predicted to be involved in positive regulation of neuron migration; positive regulation of transcription by RNA polymerase II; and regulation of myoblast proliferation. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Orthologous to human ZNF609 (zinc finger protein 609). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 43.4), Adrenal (RPKM 42.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zfp609 in Genome Data Viewer
    Location:
    8q24
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (75109676..75243045, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (66214553..66349319, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (71230830..71337746, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene RNA binding protein, mRNA processing factor 2 Neighboring gene uncharacterized LOC103693122 Neighboring gene ornithine decarboxylase antizyme 2 Neighboring gene thyroid hormone receptor interactor 4 Neighboring gene U6 spliceosomal RNA Neighboring gene PCNA clamp associated factor Neighboring gene casein kinase 1, gamma 1 Neighboring gene small nucleolar RNA SNORA17

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Circular RNA-ZNF609 regulates corneal neovascularization by acting as a sponge of miR-184. Wu P, et al. Exp Eye Res, 2020 Mar. PMID 31954666
    2. Circular RNA-ZNF609 regulates retinal neurodegeneration by acting as miR-615 sponge. Wang JJ, et al. Theranostics, 2018. PMID 29930739, Free PMC Article
    3. Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis. Legnini I, et al. Mol Cell, 2017 Apr 6. PMID 28344082, Free PMC Article
    4. Nipbl Interacts with Zfp609 and the Integrator Complex to Regulate Cortical Neuron Migration. van den Berg DLC, et al. Neuron, 2017 Jan 18. PMID 28041881, Free PMC Article
    5. Reciprocal regulation of Rag expression in thymocytes by the zinc-finger proteins, Zfp608 and Zfp609. Reed NP, et al. Genes Immun, 2013 Jan. PMID 23076336, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Circular RNA-ZNF609 regulates corneal neovascularization by acting as a sponge of miR-184.
      Title: Circular RNA-ZNF609 regulates corneal neovascularization by acting as a sponge of miR-184.
    2. cZNF609 acted as an endogenous miR-615 sponge to sequester and inhibit miR-615 activity, which led to increased METRN.
      Title: Circular RNA-ZNF609 regulates retinal neurodegeneration by acting as miR-615 sponge.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables promoter-specific chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of neuron migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of myoblast proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 609

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001173371.1 → NP_001166842.1  zinc finger protein 609

      See identical proteins and their annotated locations for NP_001166842.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      D4ACN4
      Related
      ENSRNOP00000021554.5, ENSRNOT00000021554.8
      Conserved Domains (2) summary
      PTZ00449
      Location:1007 → 1226
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      COG5189
      Location:412 → 533
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      75109676..75243045 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039081824.2 → XP_038937752.1  zinc finger protein 609 isoform X1

      UniProtKB/TrEMBL
      D4ACN4
      Conserved Domains (2) summary
      PTZ00449
      Location:1007 → 1226
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      COG5189
      Location:412 → 533
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]

    2. XM_063265861.1 → XP_063121931.1  zinc finger protein 609 isoform X2

      UniProtKB/TrEMBL
      A6J5G3

    3. XM_063265862.1 → XP_063121932.1  zinc finger protein 609 isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version

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