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    Slc25a36 solute carrier family 25 member 36 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 501039, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Slc25a36provided by RGD
    Official Full Name
    solute carrier family 25 member 36provided by RGD
    Primary source
    RGD:1591928
    See related
    EnsemblRapid:ENSRNOG00000078852 AllianceGenome:RGD:1591928
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable pyrimidine nucleotide transmembrane transporter activity. Predicted to be involved in mitochondrial genome maintenance; pyrimidine nucleotide import into mitochondrion; and regulation of mitochondrial membrane potential. Predicted to be located in mitochondrial inner membrane. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in familial hyperinsulinemic hypoglycemia 8. Orthologous to human SLC25A36 (solute carrier family 25 member 36). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 545.6), Lung (RPKM 416.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Slc25a36 in Genome Data Viewer
    Location:
    8q31
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (106539355..106573240, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (97659848..97693735, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (104962569..104995935, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480089 Neighboring gene uncharacterized LOC134480218 Neighboring gene BCL2 associated X, apoptosis regulator, pseudogene 1 Neighboring gene 40S ribosomal protein S17-like Neighboring gene tripartite motif-containing 42

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The human SLC25A33 and SLC25A36 genes of solute carrier family 25 encode two mitochondrial pyrimidine nucleotide transporters. Di Noia MA, et al. J Biol Chem, 2014 Nov 28. PMID 25320081, Free PMC Article
    2. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables pyrimidine nucleotide transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pyrimidine nucleotide transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial genome maintenance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial genome maintenance ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrion organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in pyrimidine nucleotide import into mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pyrimidine nucleotide transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mitochondrial membrane potential ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    solute carrier family 25 member 36
    Names
    solute carrier family 25 (pyrimidine nucleotide carrier ), member 36

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427729.1 → NP_001414658.1  solute carrier family 25 member 36

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      D4ACN9
      Related
      ENSRNOP00000033519.3, ENSRNOT00000037120.7

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      106539355..106573240 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008766577.4 → XP_008764799.1  solute carrier family 25 member 36 isoform X1

      See identical proteins and their annotated locations for XP_008764799.1

      UniProtKB/TrEMBL
      A0A0G2JV03
      Related
      ENSRNOP00000109110.1, ENSRNOT00000131210.1
      Conserved Domains (1) summary
      pfam00153
      Location:88 → 180
      Mito_carr; Mitochondrial carrier protein

    2. XM_063265997.1 → XP_063122067.1  solute carrier family 25 member 36 isoform X2

    3. XM_063265996.1 → XP_063122066.1  solute carrier family 25 member 36 isoform X2

    4. XM_039082574.2 → XP_038938502.1  solute carrier family 25 member 36 isoform X2

      Conserved Domains (1) summary
      pfam00153
      Location:30 → 105
      Mito_carr; Mitochondrial carrier protein

    5. XM_039082571.2 → XP_038938499.1  solute carrier family 25 member 36 isoform X2

      Conserved Domains (1) summary
      pfam00153
      Location:30 → 105
      Mito_carr; Mitochondrial carrier protein
    Nucleotide Protein Strain
    Heading Accession and Version

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