Oxa1l OXA1L, mitochondrial inner membrane protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Oxa1lprovided by RGD
Official Full Name: OXA1L, mitochondrial inner membrane proteinprovided by RGD
Primary source: RGD:1585024
See related: EnsemblRapid:ENSRNOG00000009713 AllianceGenome:RGD:1585024
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable membrane insertase activity; mitochondrial ribosome binding activity; and protein homodimerization activity. Predicted to be involved in several processes, including mitochondrial protein quality control; mitochondrion organization; and protein tetramerization. Predicted to be located in mitochondrial membrane. Predicted to be part of protein-containing complex. Predicted to be active in mitochondrial inner membrane. Orthologous to human OXA1L (OXA1L mitochondrial inner membrane protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Heart (RPKM 385.8), Kidney (RPKM 310.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 15p13

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (31783725..31791353)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (27813688..27821319)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (33004957..33012584)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Topogenesis of Oxa1 is a cooperative event of all five transmembrane segments (TM), and hexapeptide GLPWWG followed immediately by TM1 is essential for correct Oxa1 topogenesis.
Title: Topogenesis of mammalian Oxa1, a component of the mitochondrial inner membrane protein export machinery.

Submit: New GeneRIF Correction

General gene information

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Markers

RH141004 (e-PCR)
- UniSTS:223004

RH132149 (e-PCR)
- UniSTS:215432

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables membrane insertase activity	IBA Inferred from Biological aspect of Ancestor more info
enables membrane insertase activity	ISO Inferred from Sequence Orthology more info
enables mitochondrial ribosome binding	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in aerobic respiration	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
involved_in mitochondrial protein quality control	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial proton-transporting ATP synthase complex assembly	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial respiratory chain complex I assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of ATP-dependent activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of oxidoreductase activity	ISO Inferred from Sequence Orthology more info
involved_in protein insertion into mitochondrial inner membrane from matrix	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein insertion into mitochondrial inner membrane from matrix	ISO Inferred from Sequence Orthology more info
involved_in protein tetramerization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in mitochondrial inner membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: mitochondrial inner membrane protein OXA1L

Names: oxidase (cytochrome c) assembly 1-like; oxidase assembly 1-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001168583.1 → NP_001162055.1 mitochondrial inner membrane protein OXA1L

See identical proteins and their annotated locations for NP_001162055.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000015

UniProtKB/TrEMBL

A6KGS2, A6KGS3, D3ZRH1

Related

ENSRNOP00000013246.5, ENSRNOT00000013246.9

Conserved Domains (1) summary

cd20069
Location:132 → 331

5TM_Oxa1-like; Five transmembrane core domain of mitochondrial inner membrane protein Oxa1 and similar proteins