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    Grsf1 G-rich RNA sequence binding factor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305256, updated on 27-Nov-2024

    Summary

    Official Symbol
    Grsf1provided by RGD
    Official Full Name
    G-rich RNA sequence binding factor 1provided by RGD
    Primary source
    RGD:1310858
    See related
    EnsemblRapid:ENSRNOG00000003392 AllianceGenome:RGD:1310858
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in positive regulation of mitochondrial RNA catabolic process and regulation of RNA splicing. Predicted to act upstream of or within anterior/posterior pattern specification and morphogenesis of embryonic epithelium. Predicted to be located in mitochondrial nucleoid and ribonucleoprotein granule. Predicted to be part of ribonucleoprotein complex. Predicted to be active in nucleoplasm. Orthologous to human GRSF1 (G-rich RNA sequence binding factor 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 529.3), Adrenal (RPKM 313.4) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Grsf1 in Genome Data Viewer
    Location:
    14p22
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (19696925..19713427)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (19412944..19429364)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (21039990..21056413)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene deoxycytidine kinase Neighboring gene MOB kinase activator 1B Neighboring gene RUN and FYVE domain containing 3 Neighboring gene microRNA 6321 Neighboring gene UTP3, small subunit processome component

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables mRNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables mRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial nucleoid ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in ribonucleoprotein granule ISO
    Inferred from Sequence Orthology
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100890.1NP_001094360.1  G-rich sequence factor 1

      Status: VALIDATED

      Source sequence(s)
      BC103654, CK474968, CK601425, FM050032
      UniProtKB/TrEMBL
      Q3SYP9
      Conserved Domains (4) summary
      COG0724
      Location:328458
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12505
      Location:248321
      RRM2_GRSF1; RNA recognition motif 2 in G-rich sequence factor 1 (GRSF-1) and similar proteins
      cd12730
      Location:148226
      RRM1_GRSF1; RNA recognition motif 1 in G-rich sequence factor 1 (GRSF-1) and similar proteins
      cd12733
      Location:400474
      RRM3_GRSF1; RNA recognition motif 3 in G-rich sequence factor 1 (GRSF-1) and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      19696925..19713427
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063273070.1XP_063129140.1  G-rich sequence factor 1 isoform X1

      UniProtKB/TrEMBL
      A6KKI3
    2. XM_006250775.5XP_006250837.1  G-rich sequence factor 1 isoform X3

      UniProtKB/TrEMBL
      F1LRK4
      Related
      ENSRNOP00000004551.7, ENSRNOT00000004551.9
      Conserved Domains (3) summary
      cd12505
      Location:131204
      RRM2_GRSF1; RNA recognition motif 2 in G-rich sequence factor 1 (GRSF-1) and similar proteins
      cd12730
      Location:31109
      RRM1_GRSF1; RNA recognition motif 1 in G-rich sequence factor 1 (GRSF-1) and similar proteins
      cd12733
      Location:283357
      RRM3_GRSF1; RNA recognition motif 3 in G-rich sequence factor 1 (GRSF-1) and similar proteins
    3. XM_063273071.1XP_063129141.1  G-rich sequence factor 1 isoform X2

      UniProtKB/TrEMBL
      A0A0G2JTY6
      Related
      ENSRNOP00000068892.1, ENSRNOT00000086571.3