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    Bcas2 BCAS2, pre-mRNA processing factor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 295334, updated on 27-Nov-2024

    Summary

    Official Symbol
    Bcas2provided by RGD
    Official Full Name
    BCAS2, pre-mRNA processing factorprovided by RGD
    Primary source
    RGD:1306485
    See related
    EnsemblRapid:ENSRNOG00000018783 AllianceGenome:RGD:1306485
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be located in centrosome and nuclear speck. Predicted to be part of DNA replication factor A complex; Prp19 complex; and U2-type catalytic step 2 spliceosome. Human ortholog(s) of this gene implicated in breast cancer. Orthologous to human BCAS2 (BCAS2 pre-mRNA processing factor). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 589.2), Heart (RPKM 274.8) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Bcas2 in Genome Data Viewer
    Location:
    2q34
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (193381000..193388881)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (190692503..190700386)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (205662633..205670514)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene adenosine monophosphate deaminase 1 Neighboring gene DENN domain containing 2C Neighboring gene carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 pseudogene Neighboring gene glutamic acid-rich protein-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in alternative mRNA splicing, via spliceosome IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within alternative mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in oocyte development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within oocyte development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within oogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ovarian follicle development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within ovarian follicle development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in spindle assembly IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within spindle assembly ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of DNA replication factor A complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of Prp19 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of Prp19 complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of U2-type catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    part_of catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of spliceosomal complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    pre-mRNA-splicing factor SPF27
    Names
    breast carcinoma amplified sequence 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106458.2NP_001099928.1  pre-mRNA-splicing factor SPF27

      See identical proteins and their annotated locations for NP_001099928.1

      Status: PROVISIONAL

      Source sequence(s)
      BC169122
      UniProtKB/TrEMBL
      A6K3K8, B5DFM8, F7F5E6
      Related
      ENSRNOP00000025592.4, ENSRNOT00000025592.8
      Conserved Domains (1) summary
      pfam05700
      Location:11214
      BCAS2; Breast carcinoma amplified sequence 2 (BCAS2)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      193381000..193388881
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)