Kif6 kinesin family member 6 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Kif6provided by RGD
Official Full Name: kinesin family member 6provided by RGD
Primary source: RGD:621070
See related: EnsemblRapid:ENSRNOG00000011453 AllianceGenome:RGD:621070
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Krp3
Summary: Predicted to enable ATP hydrolysis activity; microtubule binding activity; and microtubule motor activity. Involved in spermatogenesis. Located in male germ cell nucleus. Human ortholog(s) of this gene implicated in artery disease (multiple) and type 2 diabetes mellitus. Orthologous to human KIF6 (kinesin family member 6). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Testes (RPKM 20.2), Lung (RPKM 17.9) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q12

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (18573925..18870789, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (11076203..11373205, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (13016973..13311971, complement)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

findings suggest a possible role for KRP3 motor isoforms in spermatid maturation mediated by possible interaction with the Ran GTPase
Title: KRP3A and KRP3B: candidate motors in spermatid maturation in the seminiferous epithelium.

Submit: New GeneRIF Correction

General gene information

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Markers

AU049286 (e-PCR)
- UniSTS:145734

RH130619 (e-PCR)
- UniSTS:213903

D9Got13 (e-PCR)
- UniSTS:112276

D9Rat82 (e-PCR)
- UniSTS:119199

D9Rat88 (e-PCR)
- UniSTS:119202

AU046623 (e-PCR)
- UniSTS:111277

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule motor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in microtubule-based movement	IBA Inferred from Biological aspect of Ancestor more info
involved_in spermatogenesis	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
part_of kinesin complex	IBA Inferred from Biological aspect of Ancestor more info
located_in male germ cell nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: kinesin-like protein KIF6

Names: kinesin-related protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001431181.1 → NP_001418110.1 kinesin-like protein KIF6

Status: VALIDATED

Source sequence(s)

JAXUCZ010000009

UniProtKB/TrEMBL

E9PSL8

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086027.1 Reference GRCr8

Range

18573925..18870789 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006244480.4 → XP_006244542.1 kinesin-like protein KIF6

Related

ENSRNOP00000015584.8, ENSRNOT00000015584.9

Conserved Domains (2) summary

cd01375
Location:5 → 343

KISc_KIF9_like; Kinesin motor domain, KIF9-like subgroup

pfam00225
Location:28 → 345

Kinesin; Kinesin motor domain