Epb41l3 erythrocyte membrane protein band 4.1-like 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Epb41l3provided by RGD
Official Full Name: erythrocyte membrane protein band 4.1-like 3provided by RGD
Primary source: RGD:71089
See related: EnsemblRapid:ENSRNOG00000016724 AllianceGenome:RGD:71089
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Epb4.1l3; Kiaa0987
Summary: Predicted to enable actin binding activity and structural molecule activity. Involved in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane. Located in paranode region of axon. Is active in glutamatergic synapse and postsynapse. Human ortholog(s) of this gene implicated in esophagus squamous cell carcinoma. Orthologous to human EPB41L3 (erythrocyte membrane protein band 4.1 like 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 162.7), Kidney (RPKM 118.9) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q38

Exon count:: 29

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (116502864..116707274)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (109056178..109260607)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (117314935..117666408)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

in myelinated axons 4.1B contributes to the stabilization of membrane proteins at paranodes, to the clustering of juxtaparanodal proteins, and to the regulation of the internodal axon caliber.
Title: Protein 4.1B contributes to the organization of peripheral myelinated axons.
The 5' upstream region of Tslc1 was methylated in three hepatocellular hepatomas in which its expression was reduced, but was unmethylated in normal liver tissue. No change in expression lever of Dal-1 found in hepatocellular hepatomas.
Title: Expression and DNA methylation patterns of Tslc1 and Dal-1 genes in hepatocellular carcinomas induced by N-nitrosodiethylamine in rats.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AU048765 (e-PCR)
- UniSTS:145215

AU025418 (e-PCR)
- UniSTS:115281

RH131146 (e-PCR)
- UniSTS:214429

AU026092 (e-PCR)
- UniSTS:114620

AU026337 (e-PCR)
- UniSTS:114379

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables actin binding	IEA Inferred from Electronic Annotation more info
enables structural molecule activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in axon development	ISO Inferred from Sequence Orthology more info
involved_in cortical actin cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in myelin maintenance	ISO Inferred from Sequence Orthology more info
involved_in neuron projection morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in paranodal junction assembly	ISO Inferred from Sequence Orthology more info
involved_in paranodal junction maintenance	ISO Inferred from Sequence Orthology more info
involved_in protein localization to juxtaparanode region of axon	ISO Inferred from Sequence Orthology more info
involved_in protein localization to paranode region of axon	ISO Inferred from Sequence Orthology more info
involved_in protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell shape	ISO Inferred from Sequence Orthology more info
involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in axolemma	ISO Inferred from Sequence Orthology more info
located_in cell junction	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	ISS Inferred from Sequence or Structural Similarity more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in juxtaparanode region of axon	ISO Inferred from Sequence Orthology more info
located_in paranode region of axon	IDA Inferred from Direct Assay more info	PubMed
located_in paranode region of axon	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic density	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: band 4.1-like protein 3

Names: erythrocyte protein band 4.1-like 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001395722.1 → NP_001382651.1 band 4.1-like protein 3 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000009

UniProtKB/TrEMBL

A0A8I6AUN0, A3E0T0

Related

ENSRNOP00000040775.4, ENSRNOT00000049426.5

Conserved Domains (5) summary

smart00295
Location:115 → 304

B41; Band 4.1 homologues

cd13184
Location:299 → 392

FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family

pfam04382
Location:540 → 587

SAB; SAB domain

pfam05902
Location:757 → 862

4_1_CTD; 4.1 protein C-terminal domain (CTD)

pfam08736
Location:401 → 444

FA; FERM adjacent (FA)
NM_001395723.1 → NP_001382652.1 band 4.1-like protein 3 isoform 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000009

UniProtKB/TrEMBL

A0A8I6AUN0

Conserved Domains (4) summary

smart00295
Location:115 → 304

B41; Band 4.1 homologues

cd13184
Location:299 → 392

FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family

pfam05902
Location:675 → 753

4_1_CTD; 4.1 protein C-terminal domain (CTD)

pfam08736
Location:401 → 444

FA; FERM adjacent (FA)
NM_001395724.1 → NP_001382653.1 band 4.1-like protein 3 isoform 4

Status: VALIDATED

Source sequence(s)

JAXUCZ010000009

UniProtKB/TrEMBL

A0A8I6AUN0

Conserved Domains (2) summary

smart00295
Location:115 → 304

B41; Band 4.1 homologues

cd13184
Location:299 → 392

FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
NM_053927.2 → NP_446379.1 band 4.1-like protein 3 isoform 1

See identical proteins and their annotated locations for NP_446379.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

JAXUCZ010000009

UniProtKB/TrEMBL

A0A8I5ZSB9, A6KF70, F7EZF8, Q9JMB3

Related

ENSRNOP00000022849.3, ENSRNOT00000022849.7

Conserved Domains (5) summary

smart00295
Location:115 → 304

B41; Band 4.1 homologues

cd13184
Location:299 → 392

FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family

pfam04382
Location:733 → 781

SAB; SAB domain

pfam05902
Location:992 → 1097

4_1_CTD; 4.1 protein C-terminal domain (CTD)

pfam08736
Location:401 → 444

FA; FERM adjacent (FA)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086027.1 Reference GRCr8

Range

116502864..116707274

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063266554.1 → XP_063122624.1 band 4.1-like protein 3 isoform X15
XM_063266552.1 → XP_063122622.1 band 4.1-like protein 3 isoform X10
XM_063266563.1 → XP_063122633.1 band 4.1-like protein 3 isoform X26
XM_063266546.1 → XP_063122616.1 band 4.1-like protein 3 isoform X3
XM_063266550.1 → XP_063122620.1 band 4.1-like protein 3 isoform X8
XM_039082927.2 → XP_038938855.2 band 4.1-like protein 3 isoform X1
XM_063266555.1 → XP_063122625.1 band 4.1-like protein 3 isoform X16
XM_063266545.1 → XP_063122615.1 band 4.1-like protein 3 isoform X2
XM_063266549.1 → XP_063122619.1 band 4.1-like protein 3 isoform X7
XM_039082928.2 → XP_038938856.2 band 4.1-like protein 3 isoform X6
XM_039082931.2 → XP_038938859.2 band 4.1-like protein 3 isoform X14
XM_063266548.1 → XP_063122618.1 band 4.1-like protein 3 isoform X5
XM_039082933.2 → XP_038938861.2 band 4.1-like protein 3 isoform X17
XM_039082929.2 → XP_038938857.2 band 4.1-like protein 3 isoform X11
XM_017596242.3 → XP_017451731.2 band 4.1-like protein 3 isoform X13
XM_039082930.2 → XP_038938858.2 band 4.1-like protein 3 isoform X12
XM_063266558.1 → XP_063122628.1 band 4.1-like protein 3 isoform X20
XM_063266562.1 → XP_063122632.1 band 4.1-like protein 3 isoform X25
XM_063266556.1 → XP_063122626.1 band 4.1-like protein 3 isoform X18
XM_063266557.1 → XP_063122627.1 band 4.1-like protein 3 isoform X19
XM_039082934.2 → XP_038938862.2 band 4.1-like protein 3 isoform X23
XM_063266560.1 → XP_063122630.1 band 4.1-like protein 3 isoform X22
XM_063266569.1 → XP_063122639.1 band 4.1-like protein 3 isoform X40
XM_063266559.1 → XP_063122629.1 band 4.1-like protein 3 isoform X21
XM_039082941.2 → XP_038938869.1 band 4.1-like protein 3 isoform X37

UniProtKB/TrEMBL

A0A8I6AUN0

Conserved Domains (5) summary

smart00295
Location:115 → 304

B41; Band 4.1 homologues

cd13184
Location:299 → 392

FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family

pfam04382
Location:522 → 569

SAB; SAB domain

pfam05902
Location:739 → 844

4_1_CTD; 4.1 protein C-terminal domain (CTD)

pfam08736
Location:401 → 444

FA; FERM adjacent (FA)
XM_063266568.1 → XP_063122638.1 band 4.1-like protein 3 isoform X38
XM_063266564.1 → XP_063122634.1 band 4.1-like protein 3 isoform X30
XM_017596246.3 → XP_017451735.1 band 4.1-like protein 3 isoform X33

UniProtKB/TrEMBL

A0A8I6AUN0, A3E0T0

Conserved Domains (5) summary

smart00295
Location:115 → 304

B41; Band 4.1 homologues

cd13184
Location:299 → 392

FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family

pfam04382
Location:540 → 587

SAB; SAB domain

pfam05902
Location:757 → 862

4_1_CTD; 4.1 protein C-terminal domain (CTD)

pfam08736
Location:401 → 444

FA; FERM adjacent (FA)
XM_039082943.2 → XP_038938871.1 band 4.1-like protein 3 isoform X39

UniProtKB/TrEMBL

A0A8I5ZZJ7, A0A8I6AUN0

Conserved Domains (5) summary

smart00295
Location:115 → 304

B41; Band 4.1 homologues

cd13184
Location:299 → 392

FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family

pfam04382
Location:540 → 587

SAB; SAB domain

pfam05902
Location:757 → 835

4_1_CTD; 4.1 protein C-terminal domain (CTD)

pfam08736
Location:401 → 444

FA; FERM adjacent (FA)
XM_063266565.1 → XP_063122635.1 band 4.1-like protein 3 isoform X34
XM_039082939.2 → XP_038938867.1 band 4.1-like protein 3 isoform X36

UniProtKB/TrEMBL

A0A0G2K1Q9

Conserved Domains (5) summary

smart00295
Location:115 → 304

B41; Band 4.1 homologues

cd13184
Location:299 → 392

FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family

pfam04382
Location:533 → 581

SAB; SAB domain

pfam05902
Location:751 → 856

4_1_CTD; 4.1 protein C-terminal domain (CTD)

pfam08736
Location:401 → 444

FA; FERM adjacent (FA)
XM_039082937.2 → XP_038938865.1 band 4.1-like protein 3 isoform X31

UniProtKB/TrEMBL

A0A8I6AUN0

Conserved Domains (5) summary

smart00295
Location:115 → 304

B41; Band 4.1 homologues

cd13184
Location:299 → 392

FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family

pfam04382
Location:522 → 569

SAB; SAB domain

pfam05902
Location:780 → 885

4_1_CTD; 4.1 protein C-terminal domain (CTD)

pfam08736
Location:401 → 444

FA; FERM adjacent (FA)
XM_063266573.1 → XP_063122643.1 band 4.1-like protein 3 isoform X44
XM_017596244.3 → XP_017451733.1 band 4.1-like protein 3 isoform X27

UniProtKB/TrEMBL

A0A0G2K1Q9, A6KF71

Related

ENSRNOP00000071945.2, ENSRNOT00000088647.3

Conserved Domains (7) summary

smart00295
Location:115 → 304

B41; Band 4.1 homologues

cd13184
Location:299 → 392

FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family

pfam00373
Location:199 → 304

FERM_M; FERM central domain

pfam04382
Location:551 → 597

SAB; SAB domain

pfam05902
Location:810 → 915

4_1_CTD; 4.1 protein C-terminal domain (CTD)

pfam08736
Location:401 → 441

FA; FERM adjacent (FA)

pfam09379
Location:117 → 180

FERM_N; FERM N-terminal domain
XM_039082938.2 → XP_038938866.1 band 4.1-like protein 3 isoform X32

UniProtKB/TrEMBL

A0A0G2K1Q9

Conserved Domains (5) summary

smart00295
Location:115 → 304

B41; Band 4.1 homologues

cd13184
Location:299 → 392

FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family

pfam04382
Location:551 → 599

SAB; SAB domain

pfam05902
Location:769 → 874

4_1_CTD; 4.1 protein C-terminal domain (CTD)

pfam08736
Location:401 → 444

FA; FERM adjacent (FA)
XM_039082936.2 → XP_038938864.1 band 4.1-like protein 3 isoform X28

UniProtKB/TrEMBL

A0A8I6AUN0, F7FPP7

Related

ENSRNOP00000083187.2, ENSRNOT00000109783.2

Conserved Domains (5) summary

smart00295
Location:115 → 304

B41; Band 4.1 homologues

cd13184
Location:299 → 392

FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family

pfam04382
Location:540 → 587

SAB; SAB domain

pfam05902
Location:798 → 903

4_1_CTD; 4.1 protein C-terminal domain (CTD)

pfam08736
Location:401 → 444

FA; FERM adjacent (FA)
XM_017596247.3 → XP_017451736.1 band 4.1-like protein 3 isoform X42

UniProtKB/TrEMBL

A0A8I6AUN0

Conserved Domains (6) summary

smart00295
Location:115 → 304

B41; Band 4.1 homologues

cd13184
Location:299 → 392

FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family

pfam00373
Location:199 → 304

FERM_M; FERM central domain

pfam05902
Location:675 → 780

4_1_CTD; 4.1 protein C-terminal domain (CTD)

pfam08736
Location:401 → 441

FA; FERM adjacent (FA)

pfam09379
Location:117 → 180

FERM_N; FERM N-terminal domain
XM_063266572.1 → XP_063122642.1 band 4.1-like protein 3 isoform X43
XM_017596245.3 → XP_017451734.1 band 4.1-like protein 3 isoform X29

UniProtKB/TrEMBL

A0A0G2K1Q9

Related

ENSRNOP00000091897.2, ENSRNOT00000097689.2

Conserved Domains (7) summary

smart00295
Location:115 → 304

B41; Band 4.1 homologues

cd13184
Location:299 → 392

FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family

pfam00373
Location:199 → 304

FERM_M; FERM central domain

pfam04382
Location:533 → 579

SAB; SAB domain

pfam05902
Location:792 → 897

4_1_CTD; 4.1 protein C-terminal domain (CTD)

pfam08736
Location:401 → 441

FA; FERM adjacent (FA)

pfam09379
Location:117 → 180

FERM_N; FERM N-terminal domain
XM_063266551.1 → XP_063122621.1 band 4.1-like protein 3 isoform X9
XM_063266547.1 → XP_063122617.1 band 4.1-like protein 3 isoform X4
XM_063266571.1 → XP_063122641.1 band 4.1-like protein 3 isoform X41

UniProtKB/TrEMBL

A6KF69
XM_063266561.1 → XP_063122631.1 band 4.1-like protein 3 isoform X24

Related

ENSRNOP00000022878.5, ENSRNOT00000022878.10
XM_063266570.1 → XP_063122640.1 band 4.1-like protein 3 isoform X39

UniProtKB/TrEMBL

A0A8I5ZZJ7

Related

ENSRNOP00000083215.2, ENSRNOT00000117937.2
XM_063266567.1 → XP_063122637.1 band 4.1-like protein 3 isoform X34
XM_063266566.1 → XP_063122636.1 band 4.1-like protein 3 isoform X35

UniProtKB/TrEMBL

A0A8I5ZVK0