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    Ptpn7 protein tyrosine phosphatase, non-receptor type 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 246781, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ptpn7provided by RGD
    Official Full Name
    protein tyrosine phosphatase, non-receptor type 7provided by RGD
    Primary source
    RGD:708516
    See related
    EnsemblRapid:ENSRNOG00000005807 AllianceGenome:RGD:708516
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Heptp; Lcptp
    Summary
    Predicted to enable protein tyrosine phosphatase activity. Predicted to be involved in signal transduction. Predicted to act upstream of or within protein dephosphorylation. Predicted to be located in cytoplasmic side of plasma membrane; cytosol; and mitotic spindle. Orthologous to human PTPN7 (protein tyrosine phosphatase non-receptor type 7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 147.3), Spleen (RPKM 97.2) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ptpn7 in Genome Data Viewer
    Location:
    13q13
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (49122679..49136096)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (46570904..46584048)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (51958023..51971431)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene leucine-rich repeat-containing G protein-coupled receptor 6 Neighboring gene protein tyrosine phosphatase, receptor type, V Neighboring gene uncharacterized LOC120096252 Neighboring gene ARF like GTPase 8A Neighboring gene G protein-coupled receptor 37-like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Hematopoietic protein tyrosine phosphatase suppresses extracellular stimulus-regulated kinase activation. Gronda M, et al. Mol Cell Biol, 2001 Oct. PMID 11564869, Free PMC Article
    2. Aggregation of IgE receptors in rat basophilic leukemia 2H3 cells induces tyrosine phosphorylation of the cytosolic protein-tyrosine phosphatase HePTP. Swieter M, et al. J Biol Chem, 1995 Sep 15. PMID 7545170
    3. Haematopoietic protein tyrosine phosphatase (HePTP) phosphorylation by cAMP-dependent protein kinase in T-cells: dynamics and subcellular location. Nika K, et al. Biochem J, 2004 Mar 1. PMID 14613483, Free PMC Article
    4. Subcellular localization of intracellular protein tyrosine phosphatases in T cells. Gjörloff-Wingren A, et al. Eur J Immunol, 2000 Aug. PMID 10940933
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables histone H2AXY142 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables non-membrane spanning protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine phosphatase activity, metal-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitotic spindle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    tyrosine-protein phosphatase non-receptor type 7
    Names
    hematopoietic protein-tyrosine phosphatase
    protein-tyrosine phosphatase LC-PTP
    NP_663716.1
    XP_006249882.1
    XP_006249883.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145683.1 → NP_663716.1  tyrosine-protein phosphatase non-receptor type 7

      See identical proteins and their annotated locations for NP_663716.1

      Status: PROVISIONAL

      Source sequence(s)
      U28356
      UniProtKB/Swiss-Prot
      P49445
      UniProtKB/TrEMBL
      A6ICD8, A6ICE0
      Related
      ENSRNOP00000084393.2, ENSRNOT00000114746.2
      Conserved Domains (2) summary
      smart00194
      Location:96 → 347
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:122 → 347
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      49122679..49136096
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006249821.5 → XP_006249883.1  tyrosine-protein phosphatase non-receptor type 7 isoform X2

      See identical proteins and their annotated locations for XP_006249883.1

      UniProtKB/Swiss-Prot
      P49445
      UniProtKB/TrEMBL
      A6ICD8, A6ICE0
      Related
      ENSRNOP00000103780.1, ENSRNOT00000155289.1
      Conserved Domains (2) summary
      smart00194
      Location:96 → 347
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:122 → 347
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

    2. XM_006249820.5 → XP_006249882.1  tyrosine-protein phosphatase non-receptor type 7 isoform X1

      Conserved Domains (2) summary
      smart00194
      Location:142 → 393
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:168 → 393
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P49445.1 GenPept UniProtKB/Swiss-Prot:P49445

    Gene LinkOut

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