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    Homer3 homer scaffold protein 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29548, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Homer3provided by RGD
    Official Full Name
    homer scaffold protein 3provided by RGD
    Primary source
    RGD:620706
    See related
    EnsemblRapid:ENSRNOG00000020229 AllianceGenome:RGD:620706
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Vesl-3
    Summary
    Predicted to enable G protein-coupled glutamate receptor binding activity; identical protein binding activity; and protein domain specific binding activity. Predicted to be involved in several processes, including G protein-coupled glutamate receptor signaling pathway; negative regulation of interleukin-2 production; and regulation of signal transduction. Predicted to be located in basal part of cell and cytosol. Predicted to be active in several cellular components, including dendrite; glutamatergic synapse; and postsynaptic density. Orthologous to human HOMER3 (homer scaffold protein 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Lung (RPKM 88.9), Adrenal (RPKM 88.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Homer3 in Genome Data Viewer
    Location:
    16p14
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (19166141..19176701, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (19132177..19142739, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (20880447..20890968, complement)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene UPF1, RNA helicase and ATPase Neighboring gene ceramide synthase 1 Neighboring gene growth differentiation factor 1 Neighboring gene COPI coat complex subunit epsilon Neighboring gene DEAD-box helicase 49 Neighboring gene SURP and G patch domain containing 2 Neighboring gene transmembrane protein 60-like Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Homer proteins regulate coupling of group I metabotropic glutamate receptors to N-type calcium and M-type potassium channels. Kammermeier PJ, et al. J Neurosci, 2000 Oct 1. PMID 11007880, Free PMC Article
    2. The expression of plasticity-related genes in an acute model of stress is modulated by chronic desipramine in a time-dependent manner within medial prefrontal cortex. Nava N, et al. Eur Neuropsychopharmacol, 2017 Jan. PMID 27890541
    3. Homer is concentrated at the postsynaptic density and does not redistribute after acute synaptic stimulation. Tao-Cheng JH, et al. Neuroscience, 2014 Apr 25. PMID 24530450, Free PMC Article
    4. Phosphorylation of Homer3 by calcium/calmodulin-dependent kinase II regulates a coupling state of its target molecules in Purkinje cells. Mizutani A, et al. J Neurosci, 2008 May 14. PMID 18480293, Free PMC Article
    5. Homer 2 tunes G protein-coupled receptors stimulus intensity by regulating RGS proteins and PLCbeta GAP activities. Shin DM, et al. J Cell Biol, 2003 Jul 21. PMID 12860966, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The acute foodshake-stress induced reduction of Homer3 mRNA levels compared to sham animals at the same time point that was prevented by chronic treatment with desipramine.
      Title: The expression of plasticity-related genes in an acute model of stress is modulated by chronic desipramine in a time-dependent manner within medial prefrontal cortex.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein-coupled glutamate receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled glutamate receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled glutamate receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G protein-coupled glutamate receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of calcineurin-NFAT signaling cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of calcineurin-NFAT signaling cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of calcineurin-NFAT signaling cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of interleukin-2 production IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of interleukin-2 production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of interleukin-2 production ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of postsynaptic neurotransmitter receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of store-operated calcium entry IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in basal part of cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in postsynaptic density IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in postsynaptic density IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    homer protein homolog 3
    Names
    VASP/Ena-related gene up-regulated during seizure and LTP 3
    homer homolog 3
    homer scaffolding protein 3
    homer, neuronal immediate early gene, 3
    homer-3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053310.1 → NP_445762.1  homer protein homolog 3

      See identical proteins and their annotated locations for NP_445762.1

      Status: PROVISIONAL

      Source sequence(s)
      AB020879
      UniProtKB/Swiss-Prot
      Q9Z2X5
      UniProtKB/TrEMBL
      A6KA67
      Conserved Domains (1) summary
      cd01206
      Location:6 → 114
      EVH1_Homer_Vesl; Homer/Vesl family proteins EVH1 domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      19166141..19176701 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006252890.5 → XP_006252952.1  homer protein homolog 3 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AJC0
      Related
      ENSRNOP00000093275.1, ENSRNOT00000108210.2
      Conserved Domains (1) summary
      cd01206
      Location:6 → 114
      EVH1_Homer_Vesl; Homer/Vesl family proteins EVH1 domain

    2. XM_039094433.2 → XP_038950361.1  homer protein homolog 3 isoform X7

      UniProtKB/TrEMBL
      A0A8L2QEN4
      Related
      ENSRNOP00000027428.5, ENSRNOT00000027428.7
      Conserved Domains (2) summary
      cd01206
      Location:6 → 114
      EVH1_Homer_Vesl; Homer/Vesl family proteins EVH1 domain
      TIGR02168
      Location:95 → 312
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    3. XM_006252891.5 → XP_006252953.1  homer protein homolog 3 isoform X4

      See identical proteins and their annotated locations for XP_006252953.1

      UniProtKB/Swiss-Prot
      Q9Z2X5
      UniProtKB/TrEMBL
      A6KA67
      Conserved Domains (1) summary
      cd01206
      Location:6 → 114
      EVH1_Homer_Vesl; Homer/Vesl family proteins EVH1 domain

    4. XM_039094432.2 → XP_038950360.1  homer protein homolog 3 isoform X6

      Conserved Domains (2) summary
      COG1196
      Location:150 → 322
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd01206
      Location:6 → 114
      EVH1_Homer_Vesl; Homer/Vesl family proteins EVH1 domain

    5. XM_008771095.4 → XP_008769317.1  homer protein homolog 3 isoform X3

      Conserved Domains (1) summary
      cd01206
      Location:6 → 114
      EVH1_Homer_Vesl; Homer/Vesl family proteins EVH1 domain

    6. XM_039094431.2 → XP_038950359.1  homer protein homolog 3 isoform X5

      Conserved Domains (2) summary
      COG1196
      Location:150 → 328
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd01206
      Location:6 → 114
      EVH1_Homer_Vesl; Homer/Vesl family proteins EVH1 domain

    7. XM_008771094.4 → XP_008769316.1  homer protein homolog 3 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AH27
      Related
      ENSRNOP00000091926.1, ENSRNOT00000098457.2
      Conserved Domains (1) summary
      cd01206
      Location:6 → 114
      EVH1_Homer_Vesl; Homer/Vesl family proteins EVH1 domain

    8. XM_063275272.1 → XP_063131342.1  homer protein homolog 3 isoform X4

      UniProtKB/Swiss-Prot
      Q9Z2X5
      UniProtKB/TrEMBL
      A6KA67
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Z2X5.2 GenPept UniProtKB/Swiss-Prot:Q9Z2X5

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