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    Nucb1 nucleobindin 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 84595, updated on 27-Nov-2024

    Summary

    Official Symbol
    Nucb1provided by RGD
    Official Full Name
    nucleobindin 1provided by RGD
    Primary source
    RGD:620030
    See related
    EnsemblRapid:ENSRNOG00000020889 AllianceGenome:RGD:620030
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Nucb
    Summary
    Enables G-protein alpha-subunit binding activity; calcium ion binding activity; and guanyl-nucleotide exchange factor activity. Involved in regulation of protein targeting and small GTPase-mediated signal transduction. Located in Golgi apparatus; cytoplasmic vesicle; and extracellular space. Is extrinsic component of Golgi membrane. Orthologous to human NUCB1 (nucleobindin 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 403.7), Heart (RPKM 314.6) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Nucb1 in Genome Data Viewer
    Location:
    1q22
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (105104793..105135730, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (95968325..95999183, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (101480160..101511029, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene BCL2 associated X, apoptosis regulator Neighboring gene dihydrodiol dehydrogenase Neighboring gene TUB like protein 2 Neighboring gene protein phosphatase 1, regulatory subunit 15A Neighboring gene pleckstrin homology domain containing A4 Neighboring gene transfer RNA serine (anticodon AGA) 17

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables G-protein alpha-subunit binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calcium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in regulation of protein targeting IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in small GTPase-mediated signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Golgi cisterna membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in Golgi-associated vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in early endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in endoplasmic reticulum-Golgi intermediate compartment IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum-Golgi intermediate compartment IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum-Golgi intermediate compartment ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extrinsic component of Golgi membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lumenal side of Golgi membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in trans-Golgi network IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    nucleobindin-1
    Names
    CALNUC
    bone 63 kDa calcium-binding protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053463.3NP_445915.1  nucleobindin-1 precursor

      See identical proteins and their annotated locations for NP_445915.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      P97623, Q497A4, Q63083
      UniProtKB/TrEMBL
      A0A8L2UKK1, A6JB42
      Conserved Domains (1) summary
      pfam13499
      Location:245318
      EF-hand_7; EF-hand domain pair

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      105104793..105135730 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017589802.3XP_017445291.1  nucleobindin-1 isoform X2

      UniProtKB/TrEMBL
      A0A0G2K9Z3, A0A8L2UKK1
      Related
      ENSRNOP00000075192.2, ENSRNOT00000079633.3
    2. XM_017589801.2XP_017445290.1  nucleobindin-1 isoform X1

      UniProtKB/TrEMBL
      A0A8L2UKK1
    3. XM_006229164.5XP_006229226.1  nucleobindin-1 isoform X3

      See identical proteins and their annotated locations for XP_006229226.1

      UniProtKB/TrEMBL
      A0A8L2UKK1
      Related
      ENSRNOP00000028390.5, ENSRNOT00000028390.7
      Conserved Domains (1) summary
      pfam13499
      Location:246319
      EF-hand_7; EF-hand domain pair