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    Ucn2 urocortin 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 170896, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ucn2provided by RGD
    Official Full Name
    urocortin 2provided by RGD
    Primary source
    RGD:620765
    See related
    EnsemblRapid:ENSRNOG00000020579 AllianceGenome:RGD:620765
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ucn3
    Summary
    Enables corticotropin-releasing hormone receptor 2 binding activity. Involved in several processes, including cellular response to glucocorticoid stimulus; cellular response to hypoxia; and negative regulation of gonadotropin secretion. Located in extracellular space. Biomarker of colitis. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human UCN2 (urocortin 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 2.2), Uterus (RPKM 1.6) and 6 other tissues See more
    Orthologs
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    Genomic context

    See Ucn2 in Genome Data Viewer
    Location:
    8q32
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (118516111..118517660)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (109637624..109639173)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (117727216..117728765)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene ubiquinol-cytochrome c reductase core protein 1 Neighboring gene collagen type VII alpha 1 chain Neighboring gene microRNA 711 Neighboring gene 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 Neighboring gene uncharacterized LOC100911671 Neighboring gene uncharacterized LOC134480237

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein-coupled receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables corticotropin-releasing hormone receptor 2 binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables corticotropin-releasing hormone receptor 2 binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables corticotropin-releasing hormone receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables corticotropin-releasing hormone receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables corticotropin-releasing hormone receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables hormone activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables hormone binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables hormone binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to glucocorticoid stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to hypoxia IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cellular response to nutrient levels IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in digestion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in hormone-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in hormone-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in hormone-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of follicle-stimulating hormone secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of luteinizing hormone secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to immobilization stress IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in tissue regeneration TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    urocortin-2
    Names
    ucn II
    urocortin 3
    urocortin II

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133385.2NP_596876.2  urocortin-2 precursor

      See identical proteins and their annotated locations for NP_596876.2

      Status: VALIDATED

      Source sequence(s)
      AI454706, EF078966, JAXUCZ010000008
      UniProtKB/Swiss-Prot
      Q91WW1
      UniProtKB/TrEMBL
      A1YKY4, A6I398
      Related
      ENSRNOP00000028031.3, ENSRNOT00000028031.6
      Conserved Domains (1) summary
      pfam00473
      Location:72107
      CRF; Corticotropin-releasing factor family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      118516111..118517660
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)