Lyst lysosomal trafficking regulator [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Lystprovided by RGD
Official Full Name: lysosomal trafficking regulatorprovided by RGD
Primary source: RGD:621837
See related: EnsemblRapid:ENSRNOG00000058094 AllianceGenome:RGD:621837
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Beige
Summary: Involved in pigmentation. Predicted to be located in cytosol and microtubule cytoskeleton. Used to study Chediak-Higashi syndrome. Human ortholog(s) of this gene implicated in Chediak-Higashi syndrome. Orthologous to human LYST (lysosomal trafficking regulator). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 204.5), Lung (RPKM 143.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 17q12.3

Exon count:: 57

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (93225509..93427650)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (86241384..86443501)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (90323055..90522091, complement)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The size of intracellular granules in the granulated metrial gland cells of the beige rats was larger than for the two controls on each corresponding day of pregnancy.
Title: Histological study of granulated metrial gland (GMG) cells in beige (DA-bg/bg) rats.

Submit: New GeneRIF Correction

General gene information

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Markers

D17Rat132 (e-PCR), detects polymorphism
- UniSTS:226841

Lyst (e-PCR), detects polymorphism
- UniSTS:226197

Lyst (e-PCR), detects polymorphism
- UniSTS:226198

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
acts_upstream_of_or_within T cell mediated immunity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within blood coagulation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within defense response to bacterium	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within defense response to protozoan	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within defense response to virus	ISO Inferred from Sequence Orthology more info
involved_in endosome to lysosome transport via multivesicular body sorting pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within granulocyte chemotaxis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lysosome organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mast cell secretory granule organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within melanosome organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within microtubule-based process	ISO Inferred from Sequence Orthology more info
involved_in natural killer cell mediated cytotoxicity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neutrophil mediated immunity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within phospholipid homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within phospholipid metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within pigment granule organization	ISO Inferred from Sequence Orthology more info
involved_in pigmentation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pigmentation	ISO Inferred from Sequence Orthology more info
involved_in pigmentation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of natural killer cell activation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within secretion of lysosomal enzymes	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in microtubule cytoskeleton	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: lysosomal-trafficking regulator

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.