Dscam DS cell adhesion molecule [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dscamprovided by RGD
Official Full Name: DS cell adhesion moleculeprovided by RGD
Primary source: RGD:619992
See related: EnsemblRapid:ENSRNOG00000027992 AllianceGenome:RGD:619992
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable cell-cell adhesion mediator activity; netrin receptor binding activity; and protein tyrosine kinase binding activity. Involved in positive regulation of axon extension involved in axon guidance. Predicted to be located in dendrite; growth cone; and synapse. Predicted to be active in axon; neuronal cell body; and plasma membrane. Orthologous to human DSCAM (DS cell adhesion molecule). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 64.0), Adrenal (RPKM 9.4) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 11q11

Exon count:: 39

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (49391385..49976861, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (35921924..36507100, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (37004776..37599866, complement)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dscam is highly expressed in rat brain during the different phases of experimental epilepsy.
Title: Altered expression of Dscam in temporal lobe tissue from human and experimental animals.
DSCAM may play an important role in mesenchymal stem cells (MSCs) differentiation into neural cells.
Title: [Effects of DSCAM on differentiation of rat marrow mesenchymal stem cells into neurons in vitro].

Submit: New GeneRIF Correction

General gene information

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Markers

UniSTS:259605 (e-PCR)
- UniSTS:259605

Dscam (e-PCR), detects polymorphism
- UniSTS:259605

AU028096 (e-PCR)
- UniSTS:112663

BE114490 (e-PCR)
- UniSTS:261409

D11Rat108 (e-PCR), detects polymorphism
- UniSTS:226401

d11rat35 (e-PCR)
- UniSTS:120769

Dscam (e-PCR), detects polymorphism
- UniSTS:259071

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cell-cell adhesion mediator activity	IBA Inferred from Biological aspect of Ancestor more info
enables netrin receptor binding	IEA Inferred from Electronic Annotation more info
enables netrin receptor binding	ISO Inferred from Sequence Orthology more info
enables protein tyrosine kinase binding	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in axon guidance	IEA Inferred from Electronic Annotation more info
involved_in axon guidance	ISO Inferred from Sequence Orthology more info
involved_in axon guidance	ISS Inferred from Sequence or Structural Similarity more info
involved_in camera-type eye photoreceptor cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in central nervous system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in dendrite morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within dendrite morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in dendrite self-avoidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in dendrite self-avoidance	IEA Inferred from Electronic Annotation more info
involved_in dendrite self-avoidance	ISO Inferred from Sequence Orthology more info
involved_in dendrite self-avoidance	ISS Inferred from Sequence or Structural Similarity more info
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IBA Inferred from Biological aspect of Ancestor more info
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	ISS Inferred from Sequence or Structural Similarity more info
involved_in locomotory behavior	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within locomotory behavior	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell adhesion	ISS Inferred from Sequence or Structural Similarity more info
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
involved_in netrin-activated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in netrin-activated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in netrin-activated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of axon extension involved in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of axon extension involved in axon guidance	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of axon extension involved in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of axon extension involved in axon guidance	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in post-embryonic retina morphogenesis in camera-type eye	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within post-embryonic retina morphogenesis in camera-type eye	ISO Inferred from Sequence Orthology more info
involved_in retina layer formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in synapse assembly	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
located_in axon	ISO Inferred from Sequence Orthology more info
located_in axon	ISS Inferred from Sequence or Structural Similarity more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in dendrite	ISS Inferred from Sequence or Structural Similarity more info
located_in growth cone	IEA Inferred from Electronic Annotation more info
located_in growth cone	ISO Inferred from Sequence Orthology more info
located_in growth cone	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in neuronal cell body	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in synapse	IEA Inferred from Electronic Annotation more info
located_in synapse	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: cell adhesion molecule DSCAM

Names: Down syndrome cell adhesion molecule homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133587.1 → NP_598271.1 cell adhesion molecule DSCAM precursor

See identical proteins and their annotated locations for NP_598271.1

Status: PROVISIONAL

Source sequence(s)

AF334385

UniProtKB/Swiss-Prot

Q8VHZ8

UniProtKB/TrEMBL

F1M9F4

Related

ENSRNOP00000085284.1, ENSRNOT00000094934.2

Conserved Domains (8) summary

cd00096
Location:424 → 493

Ig; Immunoglobulin domain

cd05734
Location:707 → 784

Ig7_DSCAM; Seventh immunoglobulin (Ig)-like domain of Down Syndrome Cell Adhesion molecule (DSCAM)

smart00408
Location:239 → 300

IGc2; Immunoglobulin C-2 Type

smart00409
Location:44 → 113

IG; Immunoglobulin

smart00410
Location:236 → 310

IG_like; Immunoglobulin like

cd00063
Location:1380 → 1470

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam07679
Location:690 → 784

I-set; Immunoglobulin I-set domain

cl11960
Location:802 → 889

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086029.1 Reference GRCr8

Range

49391385..49976861 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039087936.2 → XP_038943864.1 cell adhesion molecule DSCAM isoform X1

UniProtKB/TrEMBL

A0A8I6AL19, F1M9F4

Related

ENSRNOP00000093940.1, ENSRNOT00000109924.2

Conserved Domains (7) summary

smart00408
Location:239 → 300

IGc2; Immunoglobulin C-2 Type

cd00063
Location:1380 → 1470

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam13927
Location:1287 → 1363

Ig_3; Immunoglobulin domain

cd00096
Location:505 → 507

Ig; Ig strand A [structural motif]

cd05734
Location:689 → 784

Ig_DSCAM; Immunoglobulin (Ig)-like domain of Down Syndrome Cell Adhesion molecule (DSCAM)

cd05735
Location:785 → 884

Ig_DSCAM; Immunoglobulin (Ig) domain of Down Syndrome Cell Adhesion molecule (DSCAM)

cl11960
Location:504 → 593

Ig; Immunoglobulin domain
XM_039087935.2 → XP_038943863.1 cell adhesion molecule DSCAM isoform X2

UniProtKB/TrEMBL

F1M9F4

Conserved Domains (7) summary

smart00408
Location:236 → 297

IGc2; Immunoglobulin C-2 Type

cd00063
Location:1377 → 1467

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam13927
Location:1284 → 1360

Ig_3; Immunoglobulin domain

cd00096
Location:502 → 504

Ig; Ig strand A [structural motif]

cd05734
Location:686 → 781

Ig_DSCAM; Immunoglobulin (Ig)-like domain of Down Syndrome Cell Adhesion molecule (DSCAM)

cd05735
Location:782 → 881

Ig_DSCAM; Immunoglobulin (Ig) domain of Down Syndrome Cell Adhesion molecule (DSCAM)

cl11960
Location:501 → 590

Ig; Immunoglobulin domain
XM_039087937.2 → XP_038943865.1 cell adhesion molecule DSCAM isoform X3

UniProtKB/TrEMBL

F1M9F4

Conserved Domains (6) summary

cd00063
Location:923 → 1013

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam13927
Location:830 → 906

Ig_3; Immunoglobulin domain

cd00096
Location:48 → 50

Ig; Ig strand A [structural motif]

cd05734
Location:232 → 327

Ig_DSCAM; Immunoglobulin (Ig)-like domain of Down Syndrome Cell Adhesion molecule (DSCAM)

cd05735
Location:328 → 427

Ig_DSCAM; Immunoglobulin (Ig) domain of Down Syndrome Cell Adhesion molecule (DSCAM)

cl11960
Location:47 → 136

Ig; Immunoglobulin domain
XM_039087942.2 → XP_038943870.1 cell adhesion molecule DSCAM isoform X7

UniProtKB/TrEMBL

A6IQF6

Conserved Domains (4) summary

cd00063
Location:592 → 682

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam13927
Location:499 → 575

Ig_3; Immunoglobulin domain

cd00096
Location:515 → 519

Ig; Ig strand B [structural motif]

cd05735
Location:1 → 96

Ig_DSCAM; Immunoglobulin (Ig) domain of Down Syndrome Cell Adhesion molecule (DSCAM)
XM_039087939.2 → XP_038943867.1 cell adhesion molecule DSCAM isoform X5

UniProtKB/TrEMBL

A6IQF6

Conserved Domains (4) summary

cd00063
Location:609 → 699

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam13927
Location:516 → 592

Ig_3; Immunoglobulin domain

cd00096
Location:532 → 536

Ig; Ig strand B [structural motif]

cd05735
Location:15 → 113

Ig_DSCAM; Immunoglobulin (Ig) domain of Down Syndrome Cell Adhesion molecule (DSCAM)
XM_039087940.2 → XP_038943868.1 cell adhesion molecule DSCAM isoform X6

UniProtKB/TrEMBL

A6IQF6

Conserved Domains (4) summary

cd00063
Location:598 → 688

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam13927
Location:505 → 581

Ig_3; Immunoglobulin domain

cd00096
Location:521 → 525

Ig; Ig strand B [structural motif]

cd05735
Location:4 → 102

Ig_DSCAM; Immunoglobulin (Ig) domain of Down Syndrome Cell Adhesion molecule (DSCAM)
XM_039087941.2 → XP_038943869.1 cell adhesion molecule DSCAM isoform X7

UniProtKB/TrEMBL

A6IQF6

Conserved Domains (4) summary

cd00063
Location:592 → 682

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam13927
Location:499 → 575

Ig_3; Immunoglobulin domain

cd00096
Location:515 → 519

Ig; Ig strand B [structural motif]

cd05735
Location:1 → 96

Ig_DSCAM; Immunoglobulin (Ig) domain of Down Syndrome Cell Adhesion molecule (DSCAM)
XM_063270257.1 → XP_063126327.1 cell adhesion molecule DSCAM isoform X8
XM_039087943.2 → XP_038943871.1 cell adhesion molecule DSCAM isoform X9

UniProtKB/TrEMBL

A6IQF6

Conserved Domains (3) summary

cd00063
Location:421 → 511

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam13927
Location:328 → 404

Ig_3; Immunoglobulin domain

cd00096
Location:344 → 348

Ig; Ig strand B [structural motif]
XM_039087938.2 → XP_038943866.1 cell adhesion molecule DSCAM isoform X4

Conserved Domains (6) summary

smart00408
Location:239 → 300

IGc2; Immunoglobulin C-2 Type

cd00063
Location:885 → 978

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00096
Location:505 → 507

Ig; Ig strand A [structural motif]

cd05734
Location:689 → 784

Ig_DSCAM; Immunoglobulin (Ig)-like domain of Down Syndrome Cell Adhesion molecule (DSCAM)

cd05735
Location:785 → 884

Ig_DSCAM; Immunoglobulin (Ig) domain of Down Syndrome Cell Adhesion molecule (DSCAM)

cl11960
Location:504 → 593

Ig; Immunoglobulin domain
XM_063270258.1 → XP_063126328.1 cell adhesion molecule DSCAM isoform X10
XM_063270259.1 → XP_063126329.1 cell adhesion molecule DSCAM isoform X11