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    Fat2 FAT atypical cadherin 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 65048, updated on 27-Nov-2024

    Summary

    Official Symbol
    Fat2provided by RGD
    Official Full Name
    FAT atypical cadherin 2provided by RGD
    Primary source
    RGD:620656
    See related
    EnsemblRapid:ENSRNOG00000012575 AllianceGenome:RGD:620656
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Fath2
    Summary
    Predicted to enable calcium ion binding activity. Involved in homophilic cell adhesion via plasma membrane adhesion molecules. Predicted to be located in Golgi apparatus and plasma membrane. Predicted to be active in adherens junction. Human ortholog(s) of this gene implicated in spinocerebellar ataxia 45. Orthologous to human FAT2 (FAT atypical cadherin 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 161.4) and Thymus (RPKM 46.5) See more
    Orthologs
    NEW
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    Genomic context

    See Fat2 in Genome Data Viewer
    Location:
    10q22
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (39864765..39957027, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (39364072..39456324, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (40583025..40682598, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 36 member 2 Neighboring gene uncharacterized LOC134480795 Neighboring gene solute carrier family 36 member 1 Neighboring gene uncharacterized LOC120095103 Neighboring gene secreted protein acidic and cysteine rich

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell-substrate adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell-substrate adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell-substrate adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in epithelial cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in epithelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in epithelial cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in adherens junction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in adherens junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in adherens junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in adherens junction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    protocadherin Fat 2
    Names
    FAT tumor suppressor homolog 2
    MEGF1
    multiple EGF-like domains protein 1
    multiple epidermal growth factor-like domains 1
    multiple epidermal growth factor-like domains protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022954.1NP_075243.1  protocadherin Fat 2 precursor

      See identical proteins and their annotated locations for NP_075243.1

      Status: PROVISIONAL

      Source sequence(s)
      AB011527
      UniProtKB/Swiss-Prot
      O88277
      Related
      ENSRNOP00000055459.5, ENSRNOT00000058665.6
      Conserved Domains (6) summary
      cd11304
      Location:33283424
      Cadherin_repeat; Cadherin tandem repeat domain
      cd00054
      Location:39533986
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam00008
      Location:39924022
      EGF; EGF-like domain
      pfam00028
      Location:34333524
      Cadherin; Cadherin domain
      pfam02210
      Location:38023923
      Laminin_G_2; Laminin G domain
      cl09101
      Location:18771959
      E_set; Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      39864765..39957027 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039086801.2XP_038942729.1  protocadherin Fat 2 isoform X1

      UniProtKB/TrEMBL
      F1LPM1
      Conserved Domains (6) summary
      cd11304
      Location:33283424
      Cadherin_repeat; Cadherin tandem repeat domain
      cd00054
      Location:39533986
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam00008
      Location:39924022
      EGF; EGF-like domain
      pfam00028
      Location:34333524
      Cadherin; Cadherin domain
      pfam02210
      Location:38023923
      Laminin_G_2; Laminin G domain
      cl29226
      Location:18771959
      Cadherin; Cadherin domain
    2. XM_039086802.2XP_038942730.1  protocadherin Fat 2 isoform X1

      UniProtKB/TrEMBL
      F1LPM1
      Conserved Domains (6) summary
      cd11304
      Location:33283424
      Cadherin_repeat; Cadherin tandem repeat domain
      cd00054
      Location:39533986
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam00008
      Location:39924022
      EGF; EGF-like domain
      pfam00028
      Location:34333524
      Cadherin; Cadherin domain
      pfam02210
      Location:38023923
      Laminin_G_2; Laminin G domain
      cl29226
      Location:18771959
      Cadherin; Cadherin domain