Wnt4 Wnt family member 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 84426, updated on 27-Nov-2024

Summary

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Official Symbol: Wnt4provided by RGD
Official Full Name: Wnt family member 4provided by RGD
Primary source: RGD:621348
See related: EnsemblRapid:ENSRNOG00000013166 AllianceGenome:RGD:621348
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable cytokine activity; frizzled binding activity; and transcription corepressor activity. Involved in cellular response to estradiol stimulus; response to benzoic acid; and response to retinoic acid. Predicted to be located in cell surface; cytoplasm; and extracellular matrix. Predicted to be active in extracellular space. Used to study acute kidney failure. Human ortholog(s) of this gene implicated in Mullerian aplasia and hyperandrogenism. Orthologous to human WNT4 (Wnt family member 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Adrenal (RPKM 107.5), Lung (RPKM 48.1) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

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See Wnt4 in Genome Data Viewer

Location:: 5q36

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (154797245..154818565)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (149513573..149535415)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (155649238..155668065)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study of cisplatin-induced acute kidney injury (AKI) model in rats and clinical study of contrast agent induced AKI is the first to demonstrate that increased expression of renal and urinary Wnt4 can be detected earlier than serum creatinine after drug-induced AKI suggesting that urinary Wnt4 can potentially serve as a noninvasive biomarker for monitoring patients with tubular injury.
Title: Wnt4 is significantly upregulated during the early phases of cisplatin-induced acute kidney injury.
Compared with the saline Hepatocellular carcinoma (HCC)-group, transplantation with CD34+ human hematopoietic stem cells produced a further increase in the levels of wnt4 (+19.4%) and p53 gene expression (+53%), a 2-fold increase in the percentage of cancer progenitor cells and increased HCC pathology grading
Title: Effect of human umbilical cord blood derived CD34(+) hematopoietic stem cell on the expression of Wnt4 and P53 genes in a rat model of hepatocellular carcinoma.
This suggests that soybean isoflavones could delay the process of renal interstitial fibrosis in DN rats by decreasing the expression of Wnt4, beta-catenin and TGF-beta1 in the renal interstitium, thus demonstrating that soybean isoflavones plus losartan have the best protective effects against diabetes-induced renal fibrosis.
Title: Effects of soybean isoflavones on Wnt/β-catenin and the TGF-β1 signaling pathway in renal tissue of type 2 diabetic rats.
Dvl-1 was probably a key regulator in the pathway of wnt4/beta-catenin to take part in the vascular restenosis in a rat model of balloon-injured carotid artery
Title: Wnt4/β-catenin signaling pathway modulates balloon-injured carotid artery restenosis via disheveled-1.
The 5'-flanking region of the Wnt4 gene is responsive to Pax8. Pax8 modulates the expression of Wnt4 in thyroid cells.
Title: Pax8 modulates the expression of Wnt4 that is necessary for the maintenance of the epithelial phenotype of thyroid cells.
Data indicate that spironolactone (SPI) promoted activation of the Wnt signalling pathway in mesangial cells (MCs), leading to upregulation of Wnt4 and Wnt5a mRNA expression.
Title: Spironolactone inhibits apoptosis in rat mesangial cells under hyperglycaemic conditions via the Wnt signalling pathway.
demonstrate that Wnt4 is post-transcriptionally repressed by miR-24, a Ras-induced micro RNA (miRNA) targeting the 3'-untranslated region (UTR) of Wnt4
Title: Wnt4 inhibits cell motility induced by oncogenic Ras.
Wnt4 is expressed in the adult pituitary gland and is induced by estrogen.
Title: Wnt signaling in estrogen-induced lactotroph proliferation.
IGF-1/IGF1R induces Wnt4 expression and beta-catenin activation and also stimulates growth plate chondrocyte proliferation and modestly promotes chondrocyte hypertrophy
Title: Thyroid hormone-mediated growth and differentiation of growth plate chondrocytes involves IGF-1 modulation of beta-catenin signaling.
These data indicate that thyroid hormone may regulate terminal differentiation of growth plate chondrocytes in part by modulating Wnt signaling pathways through the induction of CPZ and subsequent CPZ-enhanced activation of Wnt-4.
Title: Carboxypeptidase Z (CPZ) links thyroid hormone and Wnt signaling pathways in growth plate chondrocytes.

Submit: New GeneRIF Correction See all GeneRIFs (12)

General gene information

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Markers

Wnt4 (e-PCR), detects polymorphism
- UniSTS:465421

Wnt4 (e-PCR), detects polymorphism
- UniSTS:526100

Wnt4 (e-PCR), detects polymorphism
- UniSTS:471325

Wnt4 (e-PCR), detects polymorphism
- UniSTS:527139

Wnt4 (e-PCR), detects polymorphism
- UniSTS:525955

Wnt4 (e-PCR), detects polymorphism
- UniSTS:259461

Wnt4 (e-PCR), detects polymorphism
- UniSTS:516494

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables frizzled binding	IBA Inferred from Biological aspect of Ancestor more info
enables frizzled binding	IEA Inferred from Electronic Annotation more info
enables frizzled binding	ISO Inferred from Sequence Orthology more info
enables receptor ligand activity	IEA Inferred from Electronic Annotation more info
enables receptor ligand activity	ISO Inferred from Sequence Orthology more info
enables transcription corepressor activity	IEA Inferred from Electronic Annotation more info
enables transcription corepressor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Sertoli cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within Sertoli cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within T cell differentiation in thymus	ISO Inferred from Sequence Orthology more info
involved_in adrenal gland development	IEA Inferred from Electronic Annotation more info
involved_in adrenal gland development	ISO Inferred from Sequence Orthology more info
involved_in apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in branching involved in ureteric bud morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within branching involved in ureteric bud morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within branching morphogenesis of an epithelial tube	ISO Inferred from Sequence Orthology more info
involved_in canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in cell fate commitment	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell fate commitment	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell fate commitment	ISO Inferred from Sequence Orthology more info
involved_in cellular response to estradiol stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to starvation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to starvation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to transforming growth factor beta stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to transforming growth factor beta stimulus	ISO Inferred from Sequence Orthology more info
involved_in embryonic epithelial tube formation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within embryonic epithelial tube formation	ISO Inferred from Sequence Orthology more info
involved_in epithelial to mesenchymal transition	IEA Inferred from Electronic Annotation more info
involved_in epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
involved_in female gonad development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within female gonad development	ISO Inferred from Sequence Orthology more info
involved_in female sex determination	IEA Inferred from Electronic Annotation more info
involved_in female sex determination	ISO Inferred from Sequence Orthology more info
involved_in fibroblast growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of fibroblast growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within gamete generation	ISO Inferred from Sequence Orthology more info
involved_in hormone metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within hormone metabolic process	ISO Inferred from Sequence Orthology more info
involved_in immature T cell proliferation in thymus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within immature T cell proliferation in thymus	ISO Inferred from Sequence Orthology more info
involved_in kidney development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within kidney morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in liver development	IEA Inferred from Electronic Annotation more info
involved_in liver development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within male gonad development	ISO Inferred from Sequence Orthology more info
involved_in male gonad development	ISO Inferred from Sequence Orthology more info
involved_in mammary gland epithelium development	ISO Inferred from Sequence Orthology more info
involved_in meiotic nuclear division	IEA Inferred from Electronic Annotation more info
acts_upstream_of meiotic nuclear division	ISO Inferred from Sequence Orthology more info
involved_in mesenchymal to epithelial transition	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mesenchymal to epithelial transition	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mesonephric tubule development	ISO Inferred from Sequence Orthology more info
involved_in mesonephros development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within metanephric nephron development	ISO Inferred from Sequence Orthology more info
involved_in metanephric nephron morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within metanephric nephron morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in metanephric tubule formation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within metanephric tubule formation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within metanephros development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of androgen biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of androgen biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell migration	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of fibroblast growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of fibroblast growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of male gonad development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of male gonad development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of steroid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of testicular blood vessel morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of testicular blood vessel morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of testosterone biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of testosterone biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of wound healing	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of wound healing	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within nephron development	ISO Inferred from Sequence Orthology more info
involved_in neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in non-canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within non-canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in non-canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in oocyte development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within oocyte development	ISO Inferred from Sequence Orthology more info
involved_in paramesonephric duct development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within paramesonephric duct development	ISO Inferred from Sequence Orthology more info
involved_in paramesonephric duct development	ISO Inferred from Sequence Orthology more info
involved_in pericyte cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within pericyte cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of GTPase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of aldosterone biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of aldosterone biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of bone mineralization	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of bone mineralization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of collagen biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of collagen biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cortisol biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cortisol biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dermatome development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of dermatome development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of focal adhesion assembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of focal adhesion assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of meiotic nuclear division	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of meiotic nuclear division	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of osteoblast differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of stress fiber assembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of stress fiber assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell-cell adhesion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in renal vesicle formation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within renal vesicle formation	ISO Inferred from Sequence Orthology more info
involved_in renal vesicle induction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within renal vesicle induction	ISO Inferred from Sequence Orthology more info
involved_in response to benzoic acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to estradiol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to retinoic acid	HEP more info	PubMed
involved_in response to retinoic acid	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within sex differentiation	ISO Inferred from Sequence Orthology more info
involved_in smooth muscle cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within smooth muscle cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in somatotropin secreting cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within somatotropin secreting cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in tertiary branching involved in mammary gland duct morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within tertiary branching involved in mammary gland duct morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in thyroid-stimulating hormone-secreting cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within thyroid-stimulating hormone-secreting cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within tube morphogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in extracellular matrix	IEA Inferred from Electronic Annotation more info
located_in extracellular matrix	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein Wnt-4

Names: wingless-related MMTV integration site 4; wingless-type MMTV integration site family, member 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053402.2 → NP_445854.1 protein Wnt-4 precursor

See identical proteins and their annotated locations for NP_445854.1

Status: PROVISIONAL

Source sequence(s)

AF188608

UniProtKB/Swiss-Prot

Q9QXQ5

UniProtKB/TrEMBL

A6ITD2, F7ELZ2, Q4G052

Related

ENSRNOP00000018064.3, ENSRNOT00000018064.7

Conserved Domains (1) summary

pfam00110
Location:49 → 351

wnt; wnt family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

154797245..154818565

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039110876.2 → XP_038966804.1 protein Wnt-4 isoform X1

UniProtKB/TrEMBL

A6ITD2, F7ELZ2, Q4G052

Conserved Domains (1) summary

cd19336
Location:43 → 337

Wnt_Wnt4; Wnt domain found in protein Wnt-4 and similar proteins