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    Ralgds ral guanine nucleotide dissociation stimulator [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29622, updated on 27-Nov-2024

    Summary

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    Symbol
    Ralgdsprovided by RGD
    Full Name
    ral guanine nucleotide dissociation stimulatorprovided by RGD
    Primary source
    RGD:3533
    See related
    EnsemblRapid:ENSRNOG00000010219 AllianceGenome:RGD:3533
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Rgds
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in Ras protein signal transduction. Predicted to be located in brush border; cytosol; and nucleus. Predicted to be active in plasma membrane. Orthologous to human RALGDS (ral guanine nucleotide dissociation stimulator). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Lung (RPKM 57.0), Spleen (RPKM 45.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ralgds in Genome Data Viewer
    Location:
    3p12
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (32237644..32278045)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (11839686..11880059)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (7090134..7130548)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene piercer of microtubule wall 1 Neighboring gene mitochondrial ribosomal protein S2 Neighboring gene globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 (FORS blood group) Neighboring gene carboxyl ester lipase Neighboring gene general transcription factor IIIC subunit 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Ral GDP dissociation stimulator and Ral GTPase are involved in myocardial hypertrophy. Kawai M, et al. Hypertension, 2003 Apr. PMID 12642511
    2. Three-dimensional structure of the Ras-interacting domain of RalGDS. Huang L, et al. Nat Struct Biol, 1997 Aug. PMID 9253406
    3. Characterization of a guanine nucleotide dissociation stimulator for a ras-related GTPase. Albright CF, et al. EMBO J, 1993 Jan. PMID 8094051, Free PMC Article
    4. Activated Ras interacts with the Ral guanine nucleotide dissociation stimulator. Hofer F, et al. Proc Natl Acad Sci U S A, 1994 Nov 8. PMID 7972015, Free PMC Article
    5. Rap2A links intestinal cell polarity to brush border formation. Gloerich M, et al. Nat Cell Biol, 2012 Aug. PMID 22797597

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ral GDP dissociation stimulator is involved in myocardial hypertrophy.
      Title: Ral GDP dissociation stimulator and Ral GTPase are involved in myocardial hypertrophy.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase regulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl-nucleotide exchange factor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Ras protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in small GTPase-mediated signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in brush border ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ral guanine nucleotide dissociation stimulator
    Names
    ral guanine nucleotide exchange factor
    ralGEF

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001416483.1 → NP_001403412.1  ral guanine nucleotide dissociation stimulator isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      F1LN84

    2. NM_019250.2 → NP_062123.2  ral guanine nucleotide dissociation stimulator isoform 1

      Status: VALIDATED

      Source sequence(s)
      CB775259, CO561927, JAXUCZ010000003, L07925
      UniProtKB/Swiss-Prot
      Q03386
      Related
      ENSRNOP00000013809.8, ENSRNOT00000013809.9
      Conserved Domains (4) summary
      cd00153
      Location:779 → 864
      RalGDS_RA; Ubiquitin domain of RalGDS-like factor (RLF) and related proteins
      smart00229
      Location:112 → 236
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00155
      Location:363 → 625
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      pfam11679
      Location:193 → 332
      DUF3275; Protein of unknown function (DUF3275)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      32237644..32278045
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006233752.3 → XP_006233814.1  ral guanine nucleotide dissociation stimulator isoform X3

      UniProtKB/TrEMBL
      A0A0G2K7U4, A0A8I6A8C4
      Related
      ENSRNOP00000087735.1, ENSRNOT00000096803.2
      Conserved Domains (4) summary
      cd00153
      Location:736 → 821
      RalGDS_RA; Ubiquitin domain of RalGDS-like factor (RLF) and related proteins
      smart00229
      Location:57 → 193
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00155
      Location:320 → 582
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      pfam11679
      Location:150 → 289
      DUF3275; Protein of unknown function (DUF3275)

    2. XM_006233753.3 → XP_006233815.1  ral guanine nucleotide dissociation stimulator isoform X5

      UniProtKB/TrEMBL
      A0A0G2K7U4
      Related
      ENSRNOP00000074350.3, ENSRNOT00000084092.3
      Conserved Domains (4) summary
      cd00153
      Location:724 → 809
      RalGDS_RA; Ubiquitin domain of RalGDS-like factor (RLF) and related proteins
      smart00229
      Location:57 → 181
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00155
      Location:308 → 570
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      pfam11679
      Location:138 → 277
      DUF3275; Protein of unknown function (DUF3275)

    3. XM_006233751.5 → XP_006233813.1  ral guanine nucleotide dissociation stimulator isoform X1

      UniProtKB/TrEMBL
      A0A0G2K7U4
      Conserved Domains (4) summary
      cd00153
      Location:779 → 864
      RalGDS_RA; Ubiquitin domain of RalGDS-like factor (RLF) and related proteins
      smart00229
      Location:100 → 236
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00155
      Location:363 → 625
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      pfam11679
      Location:193 → 332
      DUF3275; Protein of unknown function (DUF3275)

    4. XM_063283357.1 → XP_063139427.1  ral guanine nucleotide dissociation stimulator isoform X6

    5. XM_063283354.1 → XP_063139424.1  ral guanine nucleotide dissociation stimulator isoform X2

      Related
      ENSRNOP00000111335.1, ENSRNOT00000164313.1

    6. XM_017591589.3 → XP_017447078.1  ral guanine nucleotide dissociation stimulator isoform X4

      UniProtKB/TrEMBL
      A0A0G2K7U4
      Related
      ENSRNOP00000100430.1, ENSRNOT00000142346.1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03386.1 GenPept UniProtKB/Swiss-Prot:Q03386

    Gene LinkOut

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