Dync1li1 dynein cytoplasmic 1 light intermediate chain 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Dync1li1provided by RGD
Full Name: dynein cytoplasmic 1 light intermediate chain 1provided by RGD
Primary source: RGD:71072
See related: EnsemblRapid:ENSRNOG00000010434 AllianceGenome:RGD:71072
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: LIC1; Dncli1; Dnclic1
Summary: Enables identical protein binding activity. Involved in cellular response to nerve growth factor stimulus and regulation of centrosome cycle. Located in centrosome; kinetochore; and late endosome. Orthologous to human DYNC1LI1 (dynein cytoplasmic 1 light intermediate chain 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 225.5), Kidney (RPKM 208.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q32

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (123254823..123288496)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (114376649..114410297)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (122743274..122776801)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LIC1, through BicD2, is required for apical nuclear migration in neural progenitors. In newborn neurons, we observe specific roles for LIC1 in the multipolar to bipolar transition and glial-guided neuronal migration. In contrast, LIC2 contributes to a novel dynein role in the little-studied mode of migration, terminal somal translocation.
Title: Distinct roles for dynein light intermediate chains in neurogenesis, migration, and terminal somal translocation.
PKA-mediated LIC1 phosphorylation causes only partial lyso/LE dispersal, suggesting a role for additional, parallel mechanisms for dynein recruitment to lyso/LEs.
Title: PKA-dependent dynein switching from lysosomes to adenovirus: a novel form of host-virus competition.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH144184 (e-PCR)
- UniSTS:233430

UniSTS:236269 (e-PCR)
- UniSTS:236269

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables GDP binding	IEA Inferred from Electronic Annotation more info
enables GDP binding	ISO Inferred from Sequence Orthology more info
NOT enables GTP binding	ISO Inferred from Sequence Orthology more info
enables dynein heavy chain binding	IBA Inferred from Biological aspect of Ancestor more info
enables dynein heavy chain binding	IEA Inferred from Electronic Annotation more info
enables dynein heavy chain binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables protein-macromolecule adaptor activity	IEA Inferred from Electronic Annotation more info
enables protein-macromolecule adaptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in cellular response to nerve growth factor stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in early endosome to recycling endosome transport	IEA Inferred from Electronic Annotation more info
involved_in early endosome to recycling endosome transport	ISO Inferred from Sequence Orthology more info
involved_in microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule-based movement	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule-based movement	IEA Inferred from Electronic Annotation more info
involved_in microtubule-based movement	ISO Inferred from Sequence Orthology more info
involved_in microtubule-based movement	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of mitotic cell cycle spindle assembly checkpoint	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of mitotic cell cycle spindle assembly checkpoint	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitotic cell cycle spindle assembly checkpoint	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of centrosome cycle	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of vesicle-mediated transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of vesicle-mediated transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of vesicle-mediated transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
part_of cytoplasmic dynein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of cytoplasmic dynein complex	IEA Inferred from Electronic Annotation more info
part_of cytoplasmic dynein complex	ISO Inferred from Sequence Orthology more info
part_of cytoplasmic dynein complex	ISS Inferred from Sequence or Structural Similarity more info
located_in endocytic vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in endocytic vesicle membrane	ISO Inferred from Sequence Orthology more info
located_in endocytic vesicle membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in kinetochore	IDA Inferred from Direct Assay more info	PubMed
located_in kinetochore	IEA Inferred from Electronic Annotation more info
located_in kinetochore	ISO Inferred from Sequence Orthology more info
located_in kinetochore	ISS Inferred from Sequence or Structural Similarity more info
located_in late endosome	IDA Inferred from Direct Assay more info	PubMed
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in recycling endosome membrane	IEA Inferred from Electronic Annotation more info
located_in spindle pole	IEA Inferred from Electronic Annotation more info
located_in spindle pole	ISO Inferred from Sequence Orthology more info
located_in spindle pole	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: cytoplasmic dynein 1 light intermediate chain 1

Names: DLC-A; cytoplasmic dynein 1 light intermediate chain 1-like; dynein light chain A; dynein light intermediate chain 1, cytosolic; dynein, cytoplasmic, light intermediate chain 1; dynein, cytoplasmic, light intermediate polypeptide 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001429260.1 → NP_001416189.1 cytoplasmic dynein 1 light intermediate chain 1 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008
NM_001429261.1 → NP_001416190.1 cytoplasmic dynein 1 light intermediate chain 1 isoform 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/Swiss-Prot

Q9QXU8
NM_145772.3 → NP_665715.2 cytoplasmic dynein 1 light intermediate chain 1 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/Swiss-Prot

Q9QXU8

UniProtKB/TrEMBL

A6I3P4, G3V7G0

Related

ENSRNOP00000014532.2, ENSRNOT00000014532.6

Conserved Domains (1) summary

pfam05783
Location:43 → 517

DLIC; Dynein light intermediate chain (DLIC)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

123254823..123288496

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039080871.2 → XP_038936799.1 cytoplasmic dynein 1 light intermediate chain 1 isoform X1

Conserved Domains (1) summary

pfam05783
Location:43 → 362

DLIC; Dynein light intermediate chain (DLIC)