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    Dnase2b deoxyribonuclease 2 beta [ Rattus norvegicus (Norway rat) ]

    Gene ID: 59296, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dnase2bprovided by RGD
    Official Full Name
    deoxyribonuclease 2 betaprovided by RGD
    Primary source
    RGD:70901
    See related
    EnsemblRapid:ENSRNOG00000016262 AllianceGenome:RGD:70901
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    UOX; Dlad
    Summary
    Enables deoxyribonuclease II activity. Predicted to be involved in apoptotic DNA fragmentation. Predicted to be located in cytoplasm and extracellular region. Orthologous to human DNASE2B (deoxyribonuclease 2 beta). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 39.3), Lung (RPKM 3.0) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dnase2b in Genome Data Viewer
    Location:
    2q44
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (238131182..238168041, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (235470915..235515211, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (252436363..252475506, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene G protein subunit gamma 5 Neighboring gene ribosome production factor 1 Neighboring gene small ribosomal subunit protein eS12-like Neighboring gene urate oxidase Neighboring gene uncharacterized LOC120100965 Neighboring gene sterile alpha motif domain containing 13

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Transcription of the rat liver uricase-encoding gene is regulated via a cis-acting element responsive to cAMP. Izuhara M, et al. Gene, 1995 Dec 29. PMID 8566790
    2. Cloning of a cDNA encoding a rat DNase II-like acid DNase. Tanuma S, et al. Biochem Biophys Res Commun, 1999 Nov 19. PMID 10558878
    3. DLAD, a novel mammalian divalent cation-independent endonuclease with homology to DNase II. Shiokawa D, et al. Nucleic Acids Res, 1999 Oct 15. PMID 10497274, Free PMC Article
    4. A 104-kDa diacylglycerol kinase containing ankyrin-like repeats localizes in the cell nucleus. Goto K, et al. Proc Natl Acad Sci U S A, 1996 Oct 1. PMID 8855332, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA endonuclease activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables deoxyribonuclease II activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables deoxyribonuclease II activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables deoxyribonuclease II activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic DNA fragmentation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in apoptotic DNA fragmentation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    deoxyribonuclease-2-beta
    Names
    DNA for uricase
    DNase II beta
    DNase II-like acid DNase
    DNase2-like acid DNase
    DNaseII-like acid DNase
    deoxyribonuclease DLAD
    deoxyribonuclease II beta
    endonuclease DLAD
    NP_067696.2
    XP_017446549.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021664.2 → NP_067696.2  deoxyribonuclease-2-beta precursor

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      Q9QZK9
      UniProtKB/TrEMBL
      A6HWE1, G3V825
      Related
      ENSRNOP00000021861.2, ENSRNOT00000021861.6
      Conserved Domains (1) summary
      pfam03265
      Location:29 → 344
      DNase_II; Deoxyribonuclease II

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      238131182..238168041 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017591060.3 → XP_017446549.1  deoxyribonuclease-2-beta isoform X1

      UniProtKB/Swiss-Prot
      Q9QZK9
      UniProtKB/TrEMBL
      A6HWE1, G3V825
      Conserved Domains (1) summary
      pfam03265
      Location:29 → 344
      DNase_II; Deoxyribonuclease II
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QZK9.1 GenPept UniProtKB/Swiss-Prot:Q9QZK9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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