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    MC1 metacaspase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 839561, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MC1
    Official Full Name
    metacaspase 1
    Primary source
    TAIR:AT1G02170
    Locus tag
    AT1G02170
    See related
    Araport:AT1G02170
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS THALIANA METACASPASE 1; ARABIDOPSIS THALIANA METACASPASE 1B; ATMC1; AtMCP1b; ATMCPB1; LOL3; LSD ONE LIKE 3; MCP1b; MCP1B; metacaspase 1; metacaspase 1b; T6A9.24
    Summary
    Encodes a type I metacaspase. Two Arabidopsis metacaspases, AT1G02170 (MC1) and AT4G25110 (MC2) antagonistically control programmed cell death in Arabidopsis. MC1 is a positive regulator of cell death and requires conserved caspase-like putative catalytic residues for its function. MC2 negatively regulates cell death. This function is independent of the putative catalytic residues. A third type I Arabidopsis metacaspase is MC3 (AT5g64240).
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    Genomic context

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    See MC1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    5
    Sequence:
    Chromosome: 1; NC_003070.9 (411664..413554)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein Neighboring gene Cox19 family protein (CHCH motif) Neighboring gene ferredoxin-like protein Neighboring gene Fatty acid hydroxylase superfamily Neighboring gene Fatty acid hydroxylase superfamily

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The plant metacaspase AtMC1 in pathogen-triggered programmed cell death and aging: functional linkage with autophagy. Coll NS, et al. Cell Death Differ, 2014 Sep. PMID 24786830, Free PMC Article
    2. AtSERPIN1 is an inhibitor of the metacaspase AtMC1-mediated cell death and autocatalytic processing in planta. Lema Asqui S, et al. New Phytol, 2018 May. PMID 28157265
    3. Arabidopsis type I metacaspases control cell death. Coll NS, et al. Science, 2010 Dec 3. PMID 21097903
    4. Two Arabidopsis metacaspases AtMCP1b and AtMCP2b are arginine/lysine-specific cysteine proteases and activate apoptosis-like cell death in yeast. Watanabe N, et al. J Biol Chem, 2005 Apr 15. PMID 15691845
    5. CrY2H-seq: a massively multiplexed assay for deep-coverage interactome mapping. Wanamaker SA, et al. Nat Methods, 2017 Aug. PMID 28650476, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. AtSerpin1 blocked AtMC1 self-processing and inhibited AtMC1-mediated cell death.
      Title: AtSERPIN1 is an inhibitor of the metacaspase AtMC1-mediated cell death and autocatalytic processing in planta.
    2. This novel pro-survival role of AtMC1 may be functionally related to its prodomain-mediated aggregate localization and potential clearance, in agreement with recent findings using the single budding yeast metacaspase YCA1.
      Title: The plant metacaspase AtMC1 in pathogen-triggered programmed cell death and aging: functional linkage with autophagy.
    3. study shows type I metacaspases, AtMC1 and AtMC2, antagonistically control programmed cell death; AtMC1 is a positive regulator of cell death; requires conserved caspase-like putative catalytic residues for function; AtMC2 negatively regulates cell death
      Title: Arabidopsis type I metacaspases control cell death.
    4. AtMCP1b and AtMCP2b are arginine/lysine-specific cysteine proteases with roles in apoptosis. [AtMCP1b]
      Title: Two Arabidopsis metacaspases AtMCP1b and AtMCP2b are arginine/lysine-specific cysteine proteases and activate apoptosis-like cell death in yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_100097.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within positive regulation of programmed cell death IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of programmed cell death IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    metacaspase 1
    NP_171719.2
    • metacaspase 1 (AMC1); FUNCTIONS IN: cysteine-type endopeptidase activity; INVOLVED IN: proteolysis, induction of apoptosis; LOCATED IN: chloroplast; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Zinc finger, LSD1-type (InterPro:IPR005735), Peptidase C14, caspase catalytic (InterPro:IPR011600); BEST Arabidopsis thaliana protein match is: metacaspase 2 (TAIR:AT4G25110.1); Has 1179 Blast hits to 1148 proteins in 266 species: Archae - 3; Bacteria - 262; Metazoa - 3; Fungi - 268; Plants - 419; Viruses - 0; Other Eukaryotes - 224 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      411664..413554
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_100097.5 → NP_171719.2  metacaspase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_171719.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O81911, Q7XJE6
      UniProtKB/TrEMBL
      A0A178W8H4, A0A5S9S592, A0A654EGQ5
      Conserved Domains (2) summary
      TIGR01053
      Location:15 → 45
      LSD1; zinc finger domain, LSD1 subclass
      pfam00656
      Location:80 → 316
      Peptidase_C14; Caspase domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7XJE6.1

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