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    MYC2 Basic helix-loop-helix (bHLH) DNA-binding family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 840158, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MYC2
    Official Full Name
    Basic helix-loop-helix (bHLH) DNA-binding family protein
    Primary source
    TAIR:AT1G32640
    Locus tag
    AT1G32640
    See related
    Araport:AT1G32640
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATMYC2; F6N18.4; F6N18_4; JAI1; JASMONATE INSENSITIVE 1; JIN1; RD22BP1; ZBF1
    Summary
    Encodes a MYC-related transcriptional activator with a typical DNA binding domain of a basic helix-loop-helix leucine zipper motif. Binds to an extended G-Box promoter motif and interacts with Jasmonate ZIM-domain proteins. Its transcription is induced by dehydration stress and ABA treatment. Negative regulator of blue light#Aeimediated photomorphogenic growth and blue and far-red-light#Aeiregulated gene expression. Positive regulator of lateral root formation. Regulates diverse JA-dependent functions. Negatively regulates Trp metabolism and biosynthesis of Trp-derived secondary metabolites. Positively regulates flavonoid biosynthesis, resistance to insects, and response to oxidative stress. Regulates other transcription factors, and negatively regulates its own expression.
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    Genomic context

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    See MYC2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    1
    Sequence:
    Chromosome: 1; NC_003070.9 (11798119..11801407, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene F-box associated ubiquitination effector family protein Neighboring gene hydroxyproline-rich glycoprotein family protein Neighboring gene tRNA-Met Neighboring gene FAM50A-like protein Neighboring gene uncharacterized protein Neighboring gene F-box and associated interaction domains-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Role of arabidopsis MYC and MYB homologs in drought- and abscisic acid-regulated gene expression. Abe H, et al. Plant Cell, 1997 Oct. PMID 9368419, Free PMC Article
    2. [Content of Osmolytes and Flavonoids under Salt Stress in Arabidopsis thaliana Plants Defective in Jasmonate Signaling]. Yastreb TO, et al. Prikl Biokhim Mikrobiol, 2016 Mar-Apr. PMID 27266252
    3. Allantoin, a stress-related purine metabolite, can activate jasmonate signaling in a MYC2-regulated and abscisic acid-dependent manner. Takagi H, et al. J Exp Bot, 2016 Apr. PMID 26931169, Free PMC Article
    4. Virulence factors of geminivirus interact with MYC2 to subvert plant resistance and promote vector performance. Li R, et al. Plant Cell, 2014 Dec. PMID 25490915, Free PMC Article
    5. Crystal Structure of Tetrameric Arabidopsis MYC2 Reveals the Mechanism of Enhanced Interaction with DNA. Lian TF, et al. Cell Rep, 2017 May 16. PMID 28514654

    See all (91) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Arabidopsis thaliana MYC2 and MYC3 Are Involved in Ethylene-Regulated Hypocotyl Growth as Negative Regulators.
      Title: Arabidopsis thaliana MYC2 and MYC3 Are Involved in Ethylene-Regulated Hypocotyl Growth as Negative Regulators.
    2. PHOSPHATE STARVATION RESPONSE1 (PHR1) interacts with JASMONATE ZIM-DOMAIN (JAZ) and MYC2 to modulate phosphate deficiency-induced jasmonate signaling in Arabidopsis.
      Title: PHOSPHATE STARVATION RESPONSE1 (PHR1) interacts with JASMONATE ZIM-DOMAIN (JAZ) and MYC2 to modulate phosphate deficiency-induced jasmonate signaling in Arabidopsis.
    3. CK2 promotes jasmonic acid signaling response by phosphorylating MYC2 in Arabidopsis.
      Title: CK2 promotes jasmonic acid signaling response by phosphorylating MYC2 in Arabidopsis.
    4. MYC2 influences salicylic acid biosynthesis and defense against bacterial pathogens in Arabidopsis thaliana.
      Title: MYC2 influences salicylic acid biosynthesis and defense against bacterial pathogens in Arabidopsis thaliana.
    5. MYB21 interacts with MYC2 to control the expression of terpene synthase genes in flowers of Freesia hybrida and Arabidopsis thaliana.
      Title: MYB21 interacts with MYC2 to control the expression of terpene synthase genes in flowers of Freesia hybrida and Arabidopsis thaliana.
    6. A bHLH transcription factor, MYC2, imparts salt intolerance by regulating proline biosynthesis in Arabidopsis.
      Title: A bHLH transcription factor, MYC2, imparts salt intolerance by regulating proline biosynthesis in Arabidopsis.
    7. MYC2, MYC3, and MYC4 function additively in wounding-induced jasmonic acid biosynthesis and catabolism.
      Title: MYC2, MYC3, and MYC4 function additively in wounding-induced jasmonic acid biosynthesis and catabolism.
    8. Jasmonic acid promotes leaf senescence through MYC2-mediated repression of CATALASE2 expression in Arabidopsis.
      Title: Jasmonic acid promotes leaf senescence through MYC2-mediated repression of CATALASE2 expression in Arabidopsis.
    9. The JA-pathway MYC transcription factors regulate photomorphogenic responses by targeting HY5 gene expression.
      Title: The JA-pathway MYC transcription factors regulate photomorphogenic responses by targeting HY5 gene expression.
    10. Integrated multi-omics framework of the plant response to jasmonic acid.
      Title: Integrated multi-omics framework of the plant response to jasmonic acid.
    Submit: New GeneRIF Correction See all GeneRIFs (54)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_102998.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sequence-specific DNA binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within extracellular ATP signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_negative_effect indole glucosinolate biosynthetic process IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_negative_effect indole glucosinolate biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within jasmonic acid mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		  
    acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of flavonoid biosynthetic process IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in protein homotetramerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of defense response to insect IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of secondary cell wall biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of tryptophan metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to abscisic acid IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to desiccation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to jasmonic acid IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to wounding IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to wounding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in root development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within stomatal complex development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_negative_effect tryptophan metabolic process IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    Basic helix-loop-helix (bHLH) DNA-binding family protein
    NP_174541.1
    • MYC2; FUNCTIONS IN: DNA binding, transcription activator activity, sequence-specific DNA binding transcription factor activity; INVOLVED IN: in 13 processes; LOCATED IN: nucleus; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Helix-loop-helix DNA-binding domain (InterPro:IPR001092), Helix-loop-helix DNA-binding (InterPro:IPR011598); BEST Arabidopsis thaliana protein match is: Basic helix-loop-helix (bHLH) DNA-binding family protein (TAIR:AT4G17880.1); Has 4078 Blast hits to 3762 proteins in 672 species: Archae - 2; Bacteria - 2; Metazoa - 761; Fungi - 108; Plants - 3150; Viruses - 25; Other Eukaryotes - 30 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      11798119..11801407 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_102998.4 → NP_174541.1  Basic helix-loop-helix (bHLH) DNA-binding family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_174541.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O48644, Q39204, Q5K1L7, Q8W2F4, Q9LPJ8
      UniProtKB/TrEMBL
      A0A178W7C3, A0A5S9WL92
      Conserved Domains (2) summary
      cd11449
      Location:445 → 521
      bHLH_AtAIB_like; basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana protein ABA-INDUCIBLE bHLH-TYPE (AIB) and similar proteins
      pfam14215
      Location:68 → 252
      bHLH-MYC_N; bHLH-MYC and R2R3-MYB transcription factors N-terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q39204.2

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