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    CDPK1 calcium-dependent protein kinase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 838470, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CDPK1
    Official Full Name
    calcium-dependent protein kinase 1
    Primary source
    TAIR:AT1G18890
    Locus tag
    AT1G18890
    See related
    Araport:AT1G18890
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATCDPK1; AtCPK10; CALCIUM-DEPENDENT PROTEIN KINASE; calcium-dependent protein kinase 1; CPK10; F6A14.1; F6A14_1
    Summary
    encodes a calcium-dependent protein kinase whose gene expression is induced by dehydration and high salt. Kinase activity could not be detected in vitro.
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    Genomic context

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    See CDPK1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    7
    Sequence:
    Chromosome: 1; NC_003070.9 (6522764..6526075, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene isochorismate synthase 2 Neighboring gene uncharacterized protein Neighboring gene Major facilitator superfamily protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Pentatricopeptide repeat (PPR) superfamily protein Neighboring gene zinc ion binding protein Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. CPK10 protein kinase regulates Arabidopsis tolerance to boron deficiency through phosphorylation and activation of BOR1 transporter. Wang Z, et al. New Phytol, 2024 Sep. PMID 38622812
    2. Arabidopsis calcium-dependent protein kinase CPK10 functions in abscisic acid- and Ca2+-mediated stomatal regulation in response to drought stress. Zou JJ, et al. Plant Physiol, 2010 Nov. PMID 20805328, Free PMC Article
    3. Structure of the regulatory apparatus of a calcium-dependent protein kinase (CDPK): a novel mode of calmodulin-target recognition. Chandran V, et al. J Mol Biol, 2006 Mar 24. PMID 16430916
    4. Ca2+-dependent protein kinases and stress signal transduction in plants. Sheen J. Science, 1996 Dec 13. PMID 8943201
    5. An optimized optogenetic clustering tool for probing protein interaction and function. Taslimi A, et al. Nat Commun, 2014 Sep 18. PMID 25233328, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CPK10 protein kinase regulates Arabidopsis tolerance to boron deficiency through phosphorylation and activation of BOR1 transporter.
      Title: CPK10 protein kinase regulates Arabidopsis tolerance to boron deficiency through phosphorylation and activation of BOR1 transporter.
    2. CPK10 is involved in plant responses to drought stress via modulation of ABA- and Ca2+-regulated stomatal movements.
      Title: Arabidopsis calcium-dependent protein kinase CPK10 functions in abscisic acid- and Ca2+-mediated stomatal regulation in response to drought stress.
    3. Results report here X-ray crystal structure of the J-CaM-LD region of calcium-dependent protein kinases from Arabidopsis thaliana (AtCPK1), determined to 2.0 A resolution.
      Title: Structure of the regulatory apparatus of a calcium-dependent protein kinase (CDPK): a novel mode of calmodulin-target recognition.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_101746.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity HDA PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within abscisic acid-activated signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within protein autophosphorylation HDA PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    calcium-dependent protein kinase 1
    NP_564066.2
    • calcium-dependent protein kinase 1 (CDPK1); FUNCTIONS IN: calmodulin-dependent protein kinase activity, protein kinase activity, kinase activity; INVOLVED IN: response to water deprivation, response to salt stress, protein amino acid phosphorylation, N-terminal protein myristoylation, abscisic acid mediated signaling pathway; LOCATED IN: chloroplast; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), EF-Hand 1, calcium-binding site (InterPro:IPR018247), Serine/threonine-protein kinase domain (InterPro:IPR002290), EF-hand-like domain (InterPro:IPR011992), Calcium-binding EF-hand (InterPro:IPR002048), EF-hand (InterPro:IPR018248), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271), Protein kinase, catalytic domain (InterPro:IPR000719), EF-HAND 2 (InterPro:IPR018249), Calcium-dependent protein kinase (InterPro:IPR020642), Calcium/calmodulin-dependent protein kinase-like (InterPro:IPR020636); BEST Arabidopsis thaliana protein match is: calcium-dependent protein kinase 30 (TAIR:AT1G74740.1); Has 125370 Blast hits to 119826 proteins in 3847 species: Archae - 176; Bacteria - 14154; Metazoa - 46310; Fungi - 16874; Plants - 24900; Viruses - 438; Other Eukaryotes - 22518 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      6522764..6526075 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_101746.5 → NP_564066.2  calcium-dependent protein kinase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_564066.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q39015, Q84W07, Q9LME1, Q9M9V8
      UniProtKB/TrEMBL
      A0A178WR71, A0A5S9V4E1, A0A654EC48
      Conserved Domains (2) summary
      COG5126
      Location:360 → 506
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      cd05117
      Location:62 → 320
      STKc_CAMK; The catalytic domain of CAMK family Serine/Threonine Kinases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9M9V8.1

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