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    MNS1 alpha-mannosidase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 841584, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MNS1
    Official Full Name
    alpha-mannosidase 1
    Primary source
    TAIR:AT1G51590
    Locus tag
    AT1G51590
    See related
    Araport:AT1G51590
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    alpha-mannosidase 1; ALPHA-MANNOSIDASE IB; F5D21.1; F5D21_1; MANIB
    Summary
    Encodes an alpha-mannosidase I enzyme responsible for N-glycan maturation.
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    Genomic context

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    See MNS1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    14
    Sequence:
    Chromosome: 1; NC_003070.9 (19128144..19132318, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Pyridoxamine 5'-phosphate oxidase family protein Neighboring gene Calcium-dependent lipid-binding (CaLB domain) plant phosphoribosyltransferase family protein Neighboring gene RNA-binding KH domain-containing protein Neighboring gene ncRNA Neighboring gene ZIM-LIKE 2 Neighboring gene Cation efflux family protein Neighboring gene Protein kinase superfamily protein Neighboring gene O-fucosyltransferase family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Two Arabidopsis thaliana Golgi alpha-mannosidase I enzymes are responsible for plant N-glycan maturation. Kajiura H, et al. Glycobiology, 2010 Feb. PMID 19914916
    2. Trimming of N-Glycans by the Golgi-Localized α-1,2-Mannosidases, MNS1 and MNS2, Is Crucial for Maintaining RSW2 Protein Abundance during Salt Stress in Arabidopsis. Liu C, et al. Mol Plant, 2018 May 7. PMID 29409894
    3. Class I alpha-mannosidases are required for N-glycan processing and root development in Arabidopsis thaliana. Liebminger E, et al. Plant Cell, 2009 Dec. PMID 20023195, Free PMC Article
    4. Time-resolved fluorescence imaging reveals differential interactions of N-glycan processing enzymes across the Golgi stack in planta. Schoberer J, et al. Plant Physiol, 2013 Apr. PMID 23400704, Free PMC Article
    5. Separating Golgi Proteins from Cis to Trans Reveals Underlying Properties of Cisternal Localization. Parsons HT, et al. Plant Cell, 2019 Sep. PMID 31266899, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MNS1/2-mediated mannose trimming of N-glycans is crucial in modulating glycoprotein abundance to withstand salt stress in plants
      Title: Trimming of N-Glycans by the Golgi-Localized α-1,2-Mannosidases, MNS1 and MNS2, Is Crucial for Maintaining RSW2 Protein Abundance during Salt Stress in Arabidopsis.
    2. Data indicate that either AtMANIa or AtMANIb can function as the Golgi alpha-mannosidase I that produces the Man(5)GlcNAc(2) N-glycan structure necessary for complex N-glycan synthesis. [MANIb]
      Title: Two Arabidopsis thaliana Golgi alpha-mannosidase I enzymes are responsible for plant N-glycan maturation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001036094.1
    NM_104037.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables alpha-mannosidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within N-glycan processing IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within N-glycan processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within root development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus HDA PubMed 
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi apparatus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in Golgi cis cisterna HDA PubMed 
    located_in endosome HDA PubMed 
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		  
    located_in trans-Golgi network HDA PubMed 

    General protein information

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    Preferred Names
    alpha-mannosidase 1
    NP_001031171.1
    • alpha-mannosidase 1 (MNS1); CONTAINS InterPro DOMAIN/s: Glycoside hydrolase, family 47 (InterPro:IPR001382); BEST Arabidopsis thaliana protein match is: alpha-mannosidase 2 (TAIR:AT3G21160.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_175570.1
    • alpha-mannosidase 1 (MNS1); CONTAINS InterPro DOMAIN/s: Glycoside hydrolase, family 47 (InterPro:IPR001382); BEST Arabidopsis thaliana protein match is: alpha-mannosidase 2 (TAIR:AT3G21160.1); Has 2056 Blast hits to 1920 proteins in 193 species: Archae - 0; Bacteria - 7; Metazoa - 790; Fungi - 850; Plants - 172; Viruses - 0; Other Eukaryotes - 237 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      19128144..19132318 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001036094.1 → NP_001031171.1  alpha-mannosidase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001031171.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9C512
      Conserved Domains (1) summary
      pfam01532
      Location:1 → 432
      Glyco_hydro_47; Glycosyl hydrolase family 47

    2. NM_104037.4 → NP_175570.1  alpha-mannosidase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_175570.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q2V4H4, Q9C512
      UniProtKB/TrEMBL
      A0A178W2E7, A0A5S9WP19
      Conserved Domains (1) summary
      pfam01532
      Location:104 → 536
      Glyco_hydro_47; Glycosyl hydrolase family 47
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9C512.1

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