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    NPC3 non-specific phospholipase C3 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 821244, updated on 18-Sep-2024

    Summary

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    Official Symbol
    NPC3
    Official Full Name
    non-specific phospholipase C3
    Primary source
    TAIR:AT3G03520
    Locus tag
    AT3G03520
    See related
    Araport:AT3G03520
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    non-specific phospholipase C3; T21P5.6; T21P5_6
    Summary
    Lysophosphatidic acid phosphatase highly expressed during phosphate starvation and abiotic stresses. Role in lipid synthesis.
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    Genomic context

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    See NPC3 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    5
    Sequence:
    Chromosome: 3; NC_003074.8 (837805..840645, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Phototropic-responsive NPH3 family protein Neighboring gene non-specific phospholipase C4 Neighboring gene non-specific phospholipase C5

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional characterization of lysophosphatidic acid phosphatase from Arabidopsis thaliana. Reddy VS, et al. Biochim Biophys Acta, 2010 Apr. PMID 20045079
    2. Nonspecific phospholipases C3 and C4 interact with PIN-FORMED2 to regulate growth and tropic responses in Arabidopsis. Li T, et al. Plant Cell, 2024 May 29. PMID 38442314,
    3. The vegetative vacuole proteome of Arabidopsis thaliana reveals predicted and unexpected proteins. Carter C, et al. Plant Cell, 2004 Dec. PMID 15539469, Free PMC Article
    4. Arabidopsis plasmodesmal proteome. Fernandez-Calvino L, et al. PLoS One, 2011 Apr 20. PMID 21533090, Free PMC Article
    5. Border control--a membrane-linked interactome of Arabidopsis. Jones AM, et al. Science, 2014 May 16. PMID 24833385

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Nonspecific phospholipases C3 and C4 interact with PIN-FORMED2 to regulate growth and tropic responses in Arabidopsis.
      Title: Nonspecific phospholipases C3 and C4 interact with PIN-FORMED2 to regulate growth and tropic responses in Arabidopsis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001337474.1
    NM_111223.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables lysophosphatidic acid phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT enables phospholipase C activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to phosphate starvation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within phosphate-containing compound metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plant-type vacuole HDA PubMed 
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasmodesma HDA PubMed 

    General protein information

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    Preferred Names
    non-specific phospholipase C3
    NP_187002.1
    • non-specific phospholipase C3 (NPC3); FUNCTIONS IN: hydrolase activity, acting on ester bonds, Lysophosphatidic acid phosphatase activity; INVOLVED IN: cellular response to phosphate starvation, phosphate metabolic process, response to abiotic stimulus; LOCATED IN: vacuole, membrane; EXPRESSED IN: 12 plant structures; EXPRESSED DURING: 6 growth stages; CONTAINS InterPro DOMAIN/s: Phosphoesterase (InterPro:IPR007312); BEST Arabidopsis thaliana protein match is: non-specific phospholipase C4 (TAIR:AT3G03530.1); Has 2235 Blast hits to 2112 proteins in 404 species: Archae - 32; Bacteria - 1866; Metazoa - 0; Fungi - 127; Plants - 159; Viruses - 0; Other Eukaryotes - 51 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      837805..840645 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_111223.5 → NP_187002.1  non-specific phospholipase C3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_187002.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8VZ53, Q9SRQ6
      UniProtKB/TrEMBL
      A0A178VBD6, A0A5S9X915
      Conserved Domains (1) summary
      pfam04185
      Location:16 → 381
      Phosphoesterase; Phosphoesterase family

    2. NM_001337474.1 → NP_001326666.1  non-specific phospholipase C3 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1I9LPZ5
      Conserved Domains (1) summary
      pfam04185
      Location:16 → 381
      Phosphoesterase; Phosphoesterase family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SRQ6.1

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