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    ACC2 acetyl-CoA carboxylase 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 840522, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ACC2
    Official Full Name
    acetyl-CoA carboxylase 2
    Primary source
    TAIR:AT1G36180
    Locus tag
    AT1G36180
    See related
    Araport:AT1G36180
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    acetyl-CoA carboxylase 2; F15C21.2; F15C21_2
    Summary
    acetyl-CoA carboxylase 2 (ACC2)
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    Genomic context

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    See ACC2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    32
    Sequence:
    Chromosome: 1; NC_003070.9 (13545965..13558600)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein Neighboring gene acetyl-CoA carboxylase 1 Neighboring gene pseudo Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Natural variation in sensitivity to a loss of chloroplast translation in Arabidopsis. Parker N, et al. Plant Physiol, 2014 Dec. PMID 25336520, Free PMC Article
    2. Genomic organization of 251 kDa acetyl-CoA carboxylase genes in Arabidopsis: tandem gene duplication has made two differentially expressed isozymes. Yanai Y, et al. Plant Cell Physiol, 1995 Jul. PMID 7551584
    3. A role of GUNs-Involved retrograde signaling in regulating Acetyl-CoA carboxylase 2 in Arabidopsis. Wang J, et al. Biochem Biophys Res Commun, 2018 Nov 2. PMID 30292412
    4. Advanced proteomic analyses yield a deep catalog of ubiquitylation targets in Arabidopsis. Kim DY, et al. Plant Cell, 2013 May. PMID 23667124, Free PMC Article
    5. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001123945.1
    NM_001333177.1
    NM_103314.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables acetyl-CoA carboxylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acetyl-CoA carboxylase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables acetyl-CoA carboxylase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables biotin carboxylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in malonyl-CoA biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    acetyl-CoA carboxylase 2
    NP_001117417.1
    • acetyl-CoA carboxylase 2 (ACC2); FUNCTIONS IN: acetyl-CoA carboxylase activity; INVOLVED IN: metabolic process; LOCATED IN: chloroplast; EXPRESSED IN: 14 plant structures; EXPRESSED DURING: 7 growth stages; CONTAINS InterPro DOMAIN/s: Carbamoyl phosphate synthase, large subunit, N-terminal (InterPro:IPR005481), Carbamoyl phosphate synthetase, large subunit, ATP-binding (InterPro:IPR005479), ATP-grasp fold, subdomain 1 (InterPro:IPR013815), PreATP-grasp-like fold (InterPro:IPR016185), Biotin carboxylation domain (InterPro:IPR011764), ATP-grasp fold, subdomain 2 (InterPro:IPR013816), Pre-ATP-grasp fold (InterPro:IPR013817); BEST Arabidopsis thaliana protein match is: acetyl-CoA carboxylase 1 (TAIR:AT1G36160.2); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
    NP_174850.4
    • acetyl-CoA carboxylase 2 (ACC2); FUNCTIONS IN: acetyl-CoA carboxylase activity; INVOLVED IN: metabolic process, fatty acid biosynthetic process; LOCATED IN: chloroplast; EXPRESSED IN: 14 plant structures; EXPRESSED DURING: 7 growth stages; CONTAINS InterPro DOMAIN/s: Acetyl-coenzyme A carboxyltransferase, N-terminal (InterPro:IPR011762), Carboxyl transferase (InterPro:IPR000022), Biotin/lipoyl attachment (InterPro:IPR000089), Carbamoyl phosphate synthase, large subunit, N-terminal (InterPro:IPR005481), PreATP-grasp-like fold (InterPro:IPR016185), ATP-grasp fold (InterPro:IPR011761), Biotin carboxylase, C-terminal (InterPro:IPR005482), Single hybrid motif (InterPro:IPR011053), Carbamoyl phosphate synthetase, large subunit, ATP-binding (InterPro:IPR005479), Acetyl-CoA carboxylase, central region (InterPro:IPR013537), Biotin-binding site (InterPro:IPR001882), Biotin carboxylation domain (InterPro:IPR011764), ATP-grasp fold, subdomain 2 (InterPro:IPR013816), Acetyl-coenzyme A carboxyltransferase, C-terminal (InterPro:IPR011763), Rudiment single hybrid motif (InterPro:IPR011054), Pre-ATP-grasp fold (InterPro:IPR013817); BEST Arabidopsis thaliana protein match is: acetyl-CoA carboxylase 1 (TAIR:AT1G36160.2); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      13545965..13558600
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001123945.1 → NP_001117417.1  acetyl-CoA carboxylase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001117417.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B3H4A7
      Conserved Domains (3) summary
      pfam00289
      Location:139 → 258
      CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
      cl10459
      Location:9 → 38
      Peptidases_S8_S53; Peptidase domain in the S8 and S53 families
      cl17255
      Location:263 → 403
      ATP-grasp_4; ATP-grasp domain

    2. NM_001333177.1 → NP_001320794.1  acetyl-CoA carboxylase 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8ANX0

    3. NM_103314.5 → NP_174850.4  acetyl-CoA carboxylase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_174850.4

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4I1L3, Q9C8G0, Q9FR96
      UniProtKB/TrEMBL
      A0A654EKR0
      Conserved Domains (8) summary
      cd06850
      Location:781 → 845
      biotinyl_domain; The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, ...
      COG0439
      Location:142 → 647
      AccC; Biotin carboxylase [Lipid transport and metabolism]
      pfam00289
      Location:139 → 258
      CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
      pfam01039
      Location:1688 → 2240
      Carboxyl_trans; Carboxyl transferase domain
      pfam02785
      Location:534 → 641
      Biotin_carb_C; Biotin carboxylase C-terminal domain
      pfam08326
      Location:846 → 1586
      ACC_central; Acetyl-CoA carboxylase, central region
      cl10459
      Location:9 → 38
      Peptidases_S8_S53; Peptidase domain in the S8 and S53 families
      cl17255
      Location:263 → 487
      ATP-grasp_4; ATP-grasp domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F4I1L3.1

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